GO Annotations Graph

• Symbol: Actn2
• Name: actinin alpha 2
• ID: MGI:109192

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IEA	J:60000
Molecular Function	GO:0051015	actin filament binding	IBA	J:265628
Molecular Function	GO:0051015	actin filament binding	IDA	J:93130
Molecular Function	GO:0051015	actin filament binding	TAS	J:32589
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0008092	cytoskeletal protein binding	IDA	J:56270
Molecular Function	GO:0008092	cytoskeletal protein binding	ISO	J:164563
Molecular Function	GO:0051373	FATZ binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0030274	LIM domain binding	IPI	J:56270
Molecular Function	GO:0030274	LIM domain binding	IPI	J:56270
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0030374	nuclear receptor coactivator activity	IDA	J:91335
Molecular Function	GO:0030374	nuclear receptor coactivator activity	IDA	J:91335
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:200304
Molecular Function	GO:0005515	protein binding	IPI	J:119025
Molecular Function	GO:0005515	protein binding	IPI	J:63100
Molecular Function	GO:0005515	protein binding	IPI	J:56270
Molecular Function	GO:0005515	protein binding	IPI	J:156784
Molecular Function	GO:0005515	protein binding	IPI	J:158675
Molecular Function	GO:0005515	protein binding	IPI	J:91335
Molecular Function	GO:0005515	protein binding	IPI	J:66484
Molecular Function	GO:0005515	protein binding	IPI	J:66484
Molecular Function	GO:0005515	protein binding	IPI	J:187422
Molecular Function	GO:0005515	protein binding	IPI	J:110295
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	TAS	J:32589
Molecular Function	GO:0031432	titin binding	ISO	J:164563
Molecular Function	GO:0070080	titin Z domain binding	ISO	J:164563
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Molecular Function	GO:0044325	transmembrane transporter binding	IPI	J:221558
Cellular Component	GO:0030054	cell junction	IBA	J:265628
Cellular Component	GO:0042995	cell projection	IBA	J:265628
Cellular Component	GO:0030864	cortical actin cytoskeleton	ISO	J:155856
Cellular Component	GO:0030864	cortical actin cytoskeleton	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0030175	filopodium	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0098871	postsynaptic actin cytoskeleton	ISO	J:155856
Cellular Component	GO:0098839	postsynaptic density membrane	ISO	J:155856
Cellular Component	GO:0099092	postsynaptic density, intracellular component	ISO	J:155856
Cellular Component	GO:0030017	sarcomere	IDA	J:211364
Cellular Component	GO:0030017	sarcomere	IDA	J:121666
Cellular Component	GO:0005865	striated muscle thin filament	TAS	J:32589
Cellular Component	GO:0030018	Z disc	ISO	J:164563
Cellular Component	GO:0030018	Z disc	IDA	J:251818
Cellular Component	GO:0030018	Z disc	IDA	J:153742
Cellular Component	GO:0030018	Z disc	IDA	J:156784
Cellular Component	GO:0030018	Z disc	IDA	J:130245
Cellular Component	GO:0030018	Z disc	IBA	J:265628
Cellular Component	GO:0030018	Z disc	IDA	J:125922
Cellular Component	GO:0030018	Z disc	IDA	J:110295
Cellular Component	GO:0030018	Z disc	IDA	J:142442
Cellular Component	GO:0030018	Z disc	IDA	J:96468
Cellular Component	GO:0030018	Z disc	IDA	J:158797
Cellular Component	GO:0030018	Z disc	IDA	J:158675
Biological Process	GO:0030036	actin cytoskeleton organization	IBA	J:265628
Biological Process	GO:0051695	actin filament uncapping	ISO	J:164563
Biological Process	GO:0055013	cardiac muscle cell development	IMP	J:153742
Biological Process	GO:0048041	focal adhesion assembly	ISO	J:164563
Biological Process	GO:0030035	microspike assembly	ISO	J:164563
Biological Process	GO:0055001	muscle cell development	IBA	J:265628
Biological Process	GO:0006936	muscle contraction	TAS	J:32589
Biological Process	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	ISO	J:164563
Biological Process	GO:0043267	negative regulation of potassium ion transport	ISO	J:164563
Biological Process	GO:2000009	negative regulation of protein localization to cell surface	ISO	J:164563
Biological Process	GO:0086097	phospholipase C-activating angiotensin-activated signaling pathway	ISO	J:164563
Biological Process	GO:2001259	positive regulation of cation channel activity	ISO	J:164563
Biological Process	GO:2001259	positive regulation of cation channel activity	IMP	J:153742
Biological Process	GO:2001137	positive regulation of endocytic recycling	ISO	J:164563
Biological Process	GO:2001137	positive regulation of endocytic recycling	IMP	J:153742
Biological Process	GO:1901018	positive regulation of potassium ion transmembrane transporter activity	ISO	J:164563
Biological Process	GO:0043268	positive regulation of potassium ion transport	ISO	J:164563
Biological Process	GO:0072659	protein localization to plasma membrane	IMP	J:153742
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0042391	regulation of membrane potential	ISO	J:164563
Biological Process	GO:0045214	sarcomere organization	ISO	J:164563