GO Annotations Graph

• Symbol: Dab2
• Name: disabled 2, mitogen-responsive phosphoprotein
• ID: MGI:109175

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0035612	AP-2 adaptor complex binding	IDA	J:188907
Molecular Function	GO:0038024	cargo receptor activity	ISO	J:164563
Molecular Function	GO:0038024	cargo receptor activity	IDA	J:188901
Molecular Function	GO:0035615	clathrin adaptor activity	IDA	J:188901
Molecular Function	GO:0035615	clathrin adaptor activity	ISO	J:164563
Molecular Function	GO:0030276	clathrin binding	IDA	J:188907
Molecular Function	GO:0005178	integrin binding	IMP	J:188906
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	ISO	J:155856
Molecular Function	GO:0035091	phosphatidylinositol binding	IDA	J:188907
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IDA	J:85533
Molecular Function	GO:0005515	protein binding	IPI	J:186107
Molecular Function	GO:0005515	protein binding	IPI	J:201942
Molecular Function	GO:0005515	protein binding	IPI	J:83951
Molecular Function	GO:0005515	protein binding	IPI	J:190256
Molecular Function	GO:0005515	protein binding	IPI	J:189999
Molecular Function	GO:0005515	protein binding	IPI	J:103399
Molecular Function	GO:0005515	protein binding	IPI	J:190009
Molecular Function	GO:0005515	protein binding	IPI	J:195218
Molecular Function	GO:0005515	protein binding	IPI	J:200407
Molecular Function	GO:0005515	protein binding	IPI	J:190002
Molecular Function	GO:0005515	protein binding	IPI	J:83951
Molecular Function	GO:0005515	protein binding	IPI	J:57874
Molecular Function	GO:0046332	SMAD binding	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:170416
Cellular Component	GO:0030132	clathrin coat of coated pit	IDA	J:188910
Cellular Component	GO:0005905	clathrin-coated pit	ISO	J:164563
Cellular Component	GO:0030136	clathrin-coated vesicle	ISO	J:164563
Cellular Component	GO:0030665	clathrin-coated vesicle membrane	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0001650	fibrillar center	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:170416
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0000904	cell morphogenesis involved in differentiation	IMP	J:79862
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	ISO	J:155856
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	IDA	J:188906
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	IDA	J:188905
Biological Process	GO:0048268	clathrin coat assembly	ISO	J:155856
Biological Process	GO:0048268	clathrin coat assembly	IDA	J:188907
Biological Process	GO:0006897	endocytosis	IEA	J:60000
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IMP	J:188906
Biological Process	GO:0071425	hematopoietic stem cell proliferation	IDA	J:266098
Biological Process	GO:0001701	in utero embryonic development	IMP	J:79862
Biological Process	GO:0035026	leading edge cell differentiation	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0030099	myeloid cell differentiation	IEP	J:74601
Biological Process	GO:0060766	negative regulation of androgen receptor signaling pathway	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:188906
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:155856
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:155856
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	ISO	J:155856
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	IMP	J:188906
Biological Process	GO:0010977	negative regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0032091	negative regulation of protein binding	ISO	J:164563
Biological Process	GO:1903077	negative regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:1903077	negative regulation of protein localization to plasma membrane	IMP	J:150406
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032349	positive regulation of aldosterone biosynthetic process	ISO	J:155856
Biological Process	GO:2000860	positive regulation of aldosterone secretion	ISO	J:155856
Biological Process	GO:0045785	positive regulation of cell adhesion	IMP	J:188906
Biological Process	GO:0045785	positive regulation of cell adhesion	IDA	J:74601
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	IMP	J:188905
Biological Process	GO:2000370	positive regulation of clathrin-dependent endocytosis	ISO	J:164563
Biological Process	GO:2000370	positive regulation of clathrin-dependent endocytosis	IDA	J:188901
Biological Process	GO:2000643	positive regulation of early endosome to late endosome transport	ISO	J:164563
Biological Process	GO:0045807	positive regulation of endocytosis	ISO	J:155856
Biological Process	GO:0045807	positive regulation of endocytosis	ISO	J:164563
Biological Process	GO:0045807	positive regulation of endocytosis	IBA	J:265628
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	IMP	J:188906
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:2001046	positive regulation of integrin-mediated signaling pathway	IMP	J:188906
Biological Process	GO:0046330	positive regulation of JNK cascade	IDA	J:188905
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IMP	J:182937
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0002092	positive regulation of receptor internalization	IMP	J:195218
Biological Process	GO:0001921	positive regulation of receptor recycling	IMP	J:182937
Biological Process	GO:0060391	positive regulation of SMAD protein signal transduction	ISO	J:164563
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	ISO	J:155856
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	IMP	J:188906
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	IDA	J:74601
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II	IMP	J:188905
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway	ISO	J:164563
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:0006898	receptor-mediated endocytosis	IBA	J:265628
Biological Process	GO:0006898	receptor-mediated endocytosis	IPI	J:79862
Biological Process	GO:2000298	regulation of Rho-dependent protein serine/threonine kinase activity	ISO	J:155856
Biological Process	GO:0097017	renal protein absorption	IMP	J:75911
Biological Process	GO:0048545	response to steroid hormone	ISO	J:155856
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000