GO Annotations Graph

• Symbol: Macf1
• Name: microtubule-actin crosslinking factor 1
• ID: MGI:108559

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0003779	actin binding	IDA	J:86459
Molecular Function	GO:0051015	actin filament binding	ISO	J:164563
Molecular Function	GO:0016887	ATP hydrolysis activity	IDA	J:143595
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008017	microtubule binding	IDA	J:86459
Molecular Function	GO:0051011	microtubule minus-end binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:143595
Molecular Function	GO:0005515	protein binding	IPI	J:143595
Molecular Function	GO:0005515	protein binding	IPI	J:175560
Molecular Function	GO:0005515	protein binding	IPI	J:175560
Molecular Function	GO:0005515	protein binding	IPI	J:110693
Molecular Function	GO:0005515	protein binding	IPI	J:110693
Molecular Function	GO:0005198	structural molecule activity	IBA	J:265628
Cellular Component	GO:0015629	actin cytoskeleton	IBA	J:265628
Cellular Component	GO:0015629	actin cytoskeleton	IDA	J:86459
Cellular Component	GO:0005938	cell cortex	ISO	J:73065
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IDA	J:170927
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:72247
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005882	intermediate filament	IBA	J:265628
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0005874	microtubule	IDA	J:143595
Cellular Component	GO:0005874	microtubule	ISO	J:164563
Cellular Component	GO:0005874	microtubule	IDA	J:170927
Cellular Component	GO:0005874	microtubule	IBA	J:265628
Cellular Component	GO:0015630	microtubule cytoskeleton	IDA	J:86459
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0014069	postsynaptic density	IDA	J:187362
Cellular Component	GO:0032587	ruffle membrane	ISO	J:164563
Biological Process	GO:0007163	establishment or maintenance of cell polarity	IMP	J:86459
Biological Process	GO:0043001	Golgi to plasma membrane protein transport	ISO	J:164563
Biological Process	GO:0045104	intermediate filament cytoskeleton organization	IBA	J:265628
Biological Process	GO:0001707	mesoderm formation	IMP	J:110693
Biological Process	GO:0001707	mesoderm formation	IMP	J:110693
Biological Process	GO:0045773	positive regulation of axon extension	ISO	J:164563
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	IMP	J:110693
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	ISO	J:155856
Biological Process	GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	IMP	J:110693
Biological Process	GO:0008104	protein localization	ISO	J:73065
Biological Process	GO:0030334	regulation of cell migration	ISO	J:164563
Biological Process	GO:0010632	regulation of epithelial cell migration	IMP	J:170927
Biological Process	GO:0010632	regulation of epithelial cell migration	IMP	J:143595
Biological Process	GO:0051893	regulation of focal adhesion assembly	ISO	J:164563
Biological Process	GO:0051893	regulation of focal adhesion assembly	IMP	J:143595
Biological Process	GO:0051893	regulation of focal adhesion assembly	IBA	J:265628
Biological Process	GO:0032886	regulation of microtubule-based process	IMP	J:170927
Biological Process	GO:0032886	regulation of microtubule-based process	ISO	J:164563
Biological Process	GO:0032886	regulation of microtubule-based process	IBA	J:265628
Biological Process	GO:0150011	regulation of neuron projection arborization	IMP	J:276410
Biological Process	GO:0016055	Wnt signaling pathway	IMP	J:110693
Biological Process	GO:0016055	Wnt signaling pathway	IGI	J:110693
Biological Process	GO:0042060	wound healing	IMP	J:170927
Biological Process	GO:0042060	wound healing	IMP	J:143595
Biological Process	GO:0042060	wound healing	IBA	J:265628