GO Annotations Graph

• Symbol: Scn9a
• Name: sodium channel, voltage-gated, type IX, alpha
• ID: MGI:107636

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005261	monoatomic cation channel activity	IEA	J:72247
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0005272	sodium channel activity	IEA	J:60000
Molecular Function	GO:0005272	sodium channel activity	TAS	Reactome:R-MMU-9717440
Molecular Function	GO:0031402	sodium ion binding	ISO	J:155856
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Molecular Function	GO:0005248	voltage-gated sodium channel activity	ISO	J:164563
Molecular Function	GO:0005248	voltage-gated sodium channel activity	ISO	J:155856
Molecular Function	GO:0005248	voltage-gated sodium channel activity	IBA	J:265628
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9717440
Cellular Component	GO:0001518	voltage-gated sodium channel complex	ISO	J:155856
Cellular Component	GO:0001518	voltage-gated sodium channel complex	IBA	J:265628
Biological Process	GO:0061368	behavioral response to formalin induced pain	ISO	J:155856
Biological Process	GO:0048266	behavioral response to pain	IMP	J:208794
Biological Process	GO:0048266	behavioral response to pain	IMP	J:92442
Biological Process	GO:0007623	circadian rhythm	IMP	J:223160
Biological Process	GO:0050974	detection of mechanical stimulus involved in sensory perception	IMP	J:223160
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	IMP	J:223160
Biological Process	GO:0006954	inflammatory response	IMP	J:92442
Biological Process	GO:0086010	membrane depolarization during action potential	IBA	J:265628
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0045759	negative regulation of action potential	ISO	J:155856
Biological Process	GO:0019228	neuronal action potential	ISO	J:155856
Biological Process	GO:0019228	neuronal action potential	IBA	J:265628
Biological Process	GO:0009791	post-embryonic development	IMP	J:92442
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:0009409	response to cold	ISO	J:155856
Biological Process	GO:0009408	response to heat	ISO	J:155856
Biological Process	GO:0009636	response to toxic substance	IDA	J:101093
Biological Process	GO:0019233	sensory perception of pain	ISO	J:164563
Biological Process	GO:0035725	sodium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0035725	sodium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006814	sodium ion transport	IEA	J:60000
Biological Process	GO:0006814	sodium ion transport	IEA	J:72247
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247