GO Annotations Graph

• Symbol: Dlg1
• Name: discs large MAGUK scaffold protein 1
• ID: MGI:107231

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	ISO	J:155856
Molecular Function	GO:0019900	kinase binding	ISO	J:168713
Molecular Function	GO:0019894	kinesin binding	ISO	J:155856
Molecular Function	GO:0097016	L27 domain binding	ISO	J:164563
Molecular Function	GO:0060090	molecular adaptor activity	IMP	J:96052
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:155856
Molecular Function	GO:0019902	phosphatase binding	ISO	J:164563
Molecular Function	GO:0015459	potassium channel regulator activity	ISO	J:164563
Molecular Function	GO:0015459	potassium channel regulator activity	IMP	J:237676
Molecular Function	GO:0005515	protein binding	IPI	J:249721
Molecular Function	GO:0005515	protein binding	IPI	J:200415
Molecular Function	GO:0005515	protein binding	IPI	J:105764
Molecular Function	GO:0005515	protein binding	IPI	J:152628
Molecular Function	GO:0005515	protein binding	IPI	J:333179
Molecular Function	GO:0005515	protein binding	IPI	J:230557
Molecular Function	GO:0005515	protein binding	IPI	J:114313
Molecular Function	GO:0005515	protein binding	IPI	J:95586
Molecular Function	GO:0005515	protein binding	IPI	J:117798
Molecular Function	GO:0005515	protein binding	IPI	J:113153
Molecular Function	GO:0005515	protein binding	IPI	J:96052
Molecular Function	GO:0005515	protein binding	IPI	J:111553
Molecular Function	GO:0005515	protein binding	IPI	J:80555
Molecular Function	GO:0005515	protein binding	IPI	J:96052
Molecular Function	GO:0005515	protein binding	IPI	J:151079
Molecular Function	GO:0005515	protein binding	IPI	J:160700
Molecular Function	GO:0005515	protein binding	IPI	J:80555
Molecular Function	GO:0005515	protein binding	IPI	J:113153
Molecular Function	GO:0005515	protein binding	IPI	J:96052
Molecular Function	GO:0005515	protein binding	IPI	J:95586
Molecular Function	GO:0005515	protein binding	IPI	J:113153
Molecular Function	GO:0005515	protein binding	IPI	J:80555
Molecular Function	GO:0005515	protein binding	IPI	J:118332
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0098919	structural constituent of postsynaptic density	IMP	J:157552
Molecular Function	GO:0098919	structural constituent of postsynaptic density	IDA	J:157552
Molecular Function	GO:0098919	structural constituent of postsynaptic density	IMP	J:157552
Molecular Function	GO:0098919	structural constituent of postsynaptic density	IEP	J:157552
Molecular Function	GO:0098919	structural constituent of postsynaptic density	IDA	J:157552
Molecular Function	GO:0098919	structural constituent of postsynaptic density	IDA	J:157552
Molecular Function	GO:0098919	structural constituent of postsynaptic density	IDA	J:157552
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Cellular Component	GO:0005912	adherens junction	TAS	J:113997
Cellular Component	GO:0009925	basal plasma membrane	ISO	J:155856
Cellular Component	GO:0005604	basement membrane	IDA	J:202984
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	TAS	J:80555
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:67360
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:178643
Cellular Component	GO:0005923	bicellular tight junction	ISO	J:164563
Cellular Component	GO:0030054	cell junction	ISO	J:164563
Cellular Component	GO:0030054	cell junction	IDA	J:178643
Cellular Component	GO:0030054	cell junction	IDA	J:178643
Cellular Component	GO:0031253	cell projection membrane	IDA	J:114581
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:73065
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:157552
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:157552
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:157552
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:157552
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:157552
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:157552
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:157552
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:157552
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:157552
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:157552
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:157552
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:157552
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:157552
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:157552
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0001772	immunological synapse	ISO	J:164563
Cellular Component	GO:0001772	immunological synapse	IDA	J:96052
Cellular Component	GO:0043219	lateral loop	IDA	J:159103
Cellular Component	GO:0016328	lateral plasma membrane	ISO	J:155856
Cellular Component	GO:0016328	lateral plasma membrane	IDA	J:114313
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	IDA	J:96052
Cellular Component	GO:0005874	microtubule	ISO	J:164563
Cellular Component	GO:0005902	microvillus	ISO	J:73065
Cellular Component	GO:0097025	MPP7-DLG1-LIN7 complex	ISO	J:164563
Cellular Component	GO:0035748	myelin sheath abaxonal region	IDA	J:159103
Cellular Component	GO:0031594	neuromuscular junction	IBA	J:265628
Cellular Component	GO:0031594	neuromuscular junction	IDA	J:103698
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	IBA	J:265628
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0033268	node of Ranvier	IDA	J:159103
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0033270	paranode region of axon	ISO	J:73065
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-443767
Cellular Component	GO:0005886	plasma membrane	IDA	J:95586
Cellular Component	GO:0005886	plasma membrane	IDA	J:111553
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IDA	J:118332
Cellular Component	GO:0098839	postsynaptic density membrane	IBA	J:265628
Cellular Component	GO:0099092	postsynaptic density, intracellular component	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0045202	synapse	IDA	J:111553
Cellular Component	GO:0097060	synaptic membrane	ISO	J:164563
Cellular Component	GO:0097060	synaptic membrane	IDA	J:201438
Cellular Component	GO:0030672	synaptic vesicle membrane	ISO	J:155856
Cellular Component	GO:0030315	T-tubule	ISO	J:155856
Biological Process	GO:0007015	actin filament organization	ISO	J:164563
Biological Process	GO:0030041	actin filament polymerization	IMP	J:96052
Biological Process	GO:0032147	activation of protein kinase activity	IMP	J:117798
Biological Process	GO:0042982	amyloid precursor protein metabolic process	IGI	J:118332
Biological Process	GO:0030953	astral microtubule organization	ISO	J:164563
Biological Process	GO:0070830	bicellular tight junction assembly	ISO	J:164563
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	IMP	J:118250
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	IMP	J:121262
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	IMP	J:114313
Biological Process	GO:0008283	cell population proliferation	IMP	J:121262
Biological Process	GO:0098609	cell-cell adhesion	ISO	J:164563
Biological Process	GO:1990416	cellular response to brain-derived neurotrophic factor stimulus	ISO	J:155856
Biological Process	GO:0007268	chemical synaptic transmission	IBA	J:265628
Biological Process	GO:0030866	cortical actin cytoskeleton organization	ISO	J:164563
Biological Process	GO:0043622	cortical microtubule organization	ISO	J:164563
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	IMP	J:67360
Biological Process	GO:0001935	endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0051660	establishment of centrosome localization	ISO	J:164563
Biological Process	GO:0060022	hard palate development	IMP	J:67360
Biological Process	GO:0060022	hard palate development	IMP	J:121262
Biological Process	GO:0001771	immunological synapse formation	IMP	J:96052
Biological Process	GO:0002088	lens development in camera-type eye	IMP	J:86871
Biological Process	GO:0002088	lens development in camera-type eye	IMP	J:86871
Biological Process	GO:0031579	membrane raft organization	IMP	J:96052
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:86871
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:86871
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:1903753	negative regulation of p38MAPK cascade	ISO	J:164563
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IMP	J:160700
Biological Process	GO:0042130	negative regulation of T cell proliferation	IMP	J:129078
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	ISO	J:155856
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IBA	J:265628
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	J:157552
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	J:157552
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	J:157552
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IMP	J:157552
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IMP	J:157552
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IEP	J:157552
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	J:157552
Biological Process	GO:0030432	peristalsis	IMP	J:118250
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IMP	J:96052
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:121262
Biological Process	GO:0048639	positive regulation of developmental growth	TAS	J:113997
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0040018	positive regulation of multicellular organism growth	TAS	J:113997
Biological Process	GO:0043268	positive regulation of potassium ion transport	ISO	J:155856
Biological Process	GO:0043268	positive regulation of potassium ion transport	ISO	J:164563
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:160700
Biological Process	GO:0008104	protein localization	IGI	J:95586
Biological Process	GO:0008104	protein localization	IMP	J:118332
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0031503	protein-containing complex localization	ISO	J:164563
Biological Process	GO:0008360	regulation of cell shape	ISO	J:164563
Biological Process	GO:0042391	regulation of membrane potential	ISO	J:164563
Biological Process	GO:0042391	regulation of membrane potential	IGI	J:95586
Biological Process	GO:0042391	regulation of membrane potential	IGI	J:95586
Biological Process	GO:0031641	regulation of myelination	IMP	J:160700
Biological Process	GO:1903764	regulation of potassium ion export across plasma membrane	IMP	J:237676
Biological Process	GO:1903286	regulation of potassium ion import	IMP	J:237676
Biological Process	GO:0032880	regulation of protein localization	ISO	J:155856
Biological Process	GO:1902473	regulation of protein localization to synapse	IDA	J:201438
Biological Process	GO:1902473	regulation of protein localization to synapse	ISO	J:164563
Biological Process	GO:0098911	regulation of ventricular cardiac muscle cell action potential	IMP	J:237676
Biological Process	GO:1903760	regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	IMP	J:237676
Biological Process	GO:0048608	reproductive structure development	IMP	J:121262
Biological Process	GO:0048608	reproductive structure development	IMP	J:121262
Biological Process	GO:0048745	smooth muscle tissue development	IMP	J:118250
Biological Process	GO:0042110	T cell activation	IMP	J:96052
Biological Process	GO:0042110	T cell activation	IMP	J:117798
Biological Process	GO:0002369	T cell cytokine production	IMP	J:96052
Biological Process	GO:0042098	T cell proliferation	IMP	J:129078
Biological Process	GO:0048729	tissue morphogenesis	IMP	J:118250
Biological Process	GO:0001657	ureteric bud development	IMP	J:121262