GO Annotations Graph

• Symbol: Adam9
• Name: ADAM metallopeptidase domain 9
• ID: MGI:105376

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005518	collagen binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	IBA	J:265628
Molecular Function	GO:0043236	laminin binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004222	metalloendopeptidase activity	ISO	J:164563
Molecular Function	GO:0004222	metalloendopeptidase activity	IDA	J:186216
Molecular Function	GO:0004222	metalloendopeptidase activity	ISO	J:164563
Molecular Function	GO:0004222	metalloendopeptidase activity	IBA	J:265628
Molecular Function	GO:1902945	metalloendopeptidase activity involved in amyloid precursor protein catabolic process	ISO	J:164563
Molecular Function	GO:0008237	metallopeptidase activity	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:113785
Molecular Function	GO:0005515	protein binding	IPI	J:233591
Molecular Function	GO:0005080	protein kinase C binding	IPI	J:51810
Molecular Function	GO:0017124	SH3 domain binding	IDA	J:31451
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:164563
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IDA	J:31451
Cellular Component	GO:0005737	cytoplasm	IDA	J:97065
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:143698
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IMP	J:143698
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:97065
Biological Process	GO:0042987	amyloid precursor protein catabolic process	ISO	J:164563
Biological Process	GO:0007155	cell adhesion	ISO	J:164563
Biological Process	GO:0033627	cell adhesion mediated by integrin	IDA	J:233591
Biological Process	GO:0033627	cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0016477	cell migration	IDA	J:233591
Biological Process	GO:0033631	cell-cell adhesion mediated by integrin	IBA	J:265628
Biological Process	GO:0007160	cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ISO	J:164563
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	IDA	J:186216
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	IDA	J:148993
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ISO	J:164563
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	IBA	J:265628
Biological Process	GO:0031293	membrane protein intracellular domain proteolysis	ISO	J:164563
Biological Process	GO:0042117	monocyte activation	ISO	J:164563
Biological Process	GO:0033630	positive regulation of cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0051549	positive regulation of keratinocyte migration	ISO	J:164563
Biological Process	GO:0034241	positive regulation of macrophage fusion	ISO	J:164563
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	IDA	J:51810
Biological Process	GO:0050714	positive regulation of protein secretion	ISO	J:164563
Biological Process	GO:0016485	protein processing	ISO	J:164563
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0006508	proteolysis	IEA	J:72247
Biological Process	GO:0051592	response to calcium ion	ISO	J:164563
Biological Process	GO:0051384	response to glucocorticoid	IMP	J:143682
Biological Process	GO:0042542	response to hydrogen peroxide	ISO	J:164563
Biological Process	GO:0010042	response to manganese ion	ISO	J:164563
Biological Process	GO:0034612	response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IMP	J:143690
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IBA	J:265628