Ptch1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Ptch1
patched 1
MGI:105373

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015485	cholesterol binding	TAS	J:113791
Molecular Function	GO:0015485	cholesterol binding	ISO	J:164563
Molecular Function	GO:0030332	cyclin binding	ISO	J:164563
Molecular Function	GO:0030332	cyclin binding	IPI	J:180492
Molecular Function	GO:0097108	hedgehog family protein binding	ISO	J:164563
Molecular Function	GO:0097108	hedgehog family protein binding	IBA	J:265628
Molecular Function	GO:0008158	hedgehog receptor activity	IBA	J:265628
Molecular Function	GO:0008158	hedgehog receptor activity	TAS	J:72380
Molecular Function	GO:0008201	heparin binding	IDA	J:113791
Molecular Function	GO:0005113	patched binding	IDA	J:113791
Molecular Function	GO:0005515	protein binding	IPI	J:113791
Molecular Function	GO:0005515	protein binding	IPI	J:200497
Molecular Function	GO:0005515	protein binding	IPI	J:118622
Molecular Function	GO:0005515	protein binding	IPI	J:251210
Molecular Function	GO:0005515	protein binding	IPI	J:226676
Molecular Function	GO:0005515	protein binding	IPI	J:201190
Molecular Function	GO:0044877	protein-containing complex binding	IDA	J:180492
Molecular Function	GO:0005119	smoothened binding	ISO	J:164563
Molecular Function	GO:0005119	smoothened binding	IBA	J:265628
Molecular Function	GO:0008270	zinc ion binding	NAS	J:113791
Cellular Component	GO:0045177	apical part of cell	ISO	J:164563
Cellular Component	GO:0044295	axonal growth cone	ISO	J:155856
Cellular Component	GO:0005901	caveola	ISO	J:164563
Cellular Component	GO:0005929	cilium	IDA	J:151923
Cellular Component	GO:0005929	cilium	IDA	J:153142
Cellular Component	GO:0044294	dendritic growth cone	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	TAS	J:113791
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0030496	midbody	IDA	J:169791
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:180534
Cellular Component	GO:0005886	plasma membrane	IDA	J:180492
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-5632642
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-5632644
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-5632654
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-517521
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	TAS	J:72380
Cellular Component	GO:0005886	plasma membrane	IDA	J:201190
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:85472
Biological Process	GO:0007420	brain development	IMP	J:175111
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	IMP	J:154102
Biological Process	GO:0061005	cell differentiation involved in kidney development	IGI	J:154102
Biological Process	GO:0001709	cell fate determination	IGI	J:210838
Biological Process	GO:0072203	cell proliferation involved in metanephros development	IMP	J:154102
Biological Process	GO:0071397	cellular response to cholesterol	ISO	J:164563
Biological Process	GO:0071397	cellular response to cholesterol	IEP	J:180534
Biological Process	GO:0071679	commissural neuron axon guidance	ISO	J:155856
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0009953	dorsal/ventral pattern formation	IGI	J:94269
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:69771
Biological Process	GO:0030326	embryonic limb morphogenesis	IMP	J:72380
Biological Process	GO:0048568	embryonic organ development	IGI	J:205269
Biological Process	GO:0009957	epidermal cell fate specification	IGI	J:210838
Biological Process	GO:0008544	epidermis development	IMP	J:124280
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:124280
Biological Process	GO:0042593	glucose homeostasis	IMP	J:65293
Biological Process	GO:0003007	heart morphogenesis	IMP	J:42441
Biological Process	GO:0035137	hindlimb morphogenesis	IMP	J:42441
Biological Process	GO:0001701	in utero embryonic development	IGI	J:182970
Biological Process	GO:0043616	keratinocyte proliferation	IMP	J:124280
Biological Process	GO:0043616	keratinocyte proliferation	IMP	J:124280
Biological Process	GO:0035108	limb morphogenesis	ISO	J:164563
Biological Process	GO:0030879	mammary gland development	IMP	J:42408
Biological Process	GO:0030879	mammary gland development	IMP	J:42408
Biological Process	GO:0060603	mammary gland duct morphogenesis	IMP	J:42408
Biological Process	GO:0060644	mammary gland epithelial cell differentiation	IMP	J:42408
Biological Process	GO:0051782	negative regulation of cell division	IMP	J:180492
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:180492
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:106653
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:219044
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:124280
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	IMP	J:124280
Biological Process	GO:0040015	negative regulation of multicellular organism growth	IMP	J:72380
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IGI	J:180534
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	NAS	J:175111
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IBA	J:265628
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IDA	J:69847
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IMP	J:72380
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IGI	J:92058
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IDA	J:38383
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IMP	J:151923
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IGI	J:142506
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IMP	J:154102
Biological Process	GO:2000647	negative regulation of stem cell proliferation	IMP	J:124280
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0021997	neural plate axis specification	IMP	J:175111
Biological Process	GO:0001843	neural tube closure	IMP	J:42441
Biological Process	GO:0001841	neural tube formation	IDA	J:113791
Biological Process	GO:0021532	neural tube patterning	ISO	J:164563
Biological Process	GO:0007389	pattern specification process	IMP	J:42441
Biological Process	GO:0060037	pharyngeal system development	ISO	J:164563
Biological Process	GO:0010875	positive regulation of cholesterol efflux	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:219044
Biological Process	GO:0045606	positive regulation of epidermal cell differentiation	IGI	J:210838
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0016485	protein processing	IMP	J:100466
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:154102
Biological Process	GO:0040008	regulation of growth	IMP	J:42441
Biological Process	GO:0007346	regulation of mitotic cell cycle	IMP	J:106653
Biological Process	GO:0032880	regulation of protein localization	IDA	J:180492
Biological Process	GO:0032880	regulation of protein localization	IMP	J:106653
Biological Process	GO:0010157	response to chlorate	IDA	J:71184
Biological Process	GO:0007165	signal transduction	IDA	J:113791
Biological Process	GO:0061053	somite development	ISO	J:164563
Biological Process	GO:0061053	somite development	IMP	J:175111
Biological Process	GO:0021522	spinal cord motor neuron differentiation	IGI	J:188764
Biological Process	GO:0072089	stem cell proliferation	IMP	J:124280
Biological Process	GO:0072089	stem cell proliferation	IMP	J:124280

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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