GO Annotations Graph

• Symbol: Gclc
• Name: glutamate-cysteine ligase, catalytic subunit
• ID: MGI:104990

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043531	ADP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0003824	catalytic activity	IEA	J:72247
Molecular Function	GO:0016595	glutamate binding	ISO	J:164563
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	ISO	J:164563
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	ISO	J:155856
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	IBA	J:265628
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	IMP	J:66499
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	IDA	J:102460
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	IDA	J:80927
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	IDA	J:91536
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	IDA	J:74071
Molecular Function	GO:0016874	ligase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:80927
Molecular Function	GO:0005515	protein binding	IPI	J:102460
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IDA	J:80927
Cellular Component	GO:0017109	glutamate-cysteine ligase complex	ISO	J:155856
Cellular Component	GO:0017109	glutamate-cysteine ligase complex	ISO	J:164563
Cellular Component	GO:0017109	glutamate-cysteine ligase complex	IBA	J:265628
Cellular Component	GO:0017109	glutamate-cysteine ligase complex	IDA	J:80927
Biological Process	GO:0097746	blood vessel diameter maintenance	ISO	J:164563
Biological Process	GO:0045454	cell redox homeostasis	ISO	J:164563
Biological Process	GO:0006534	cysteine metabolic process	ISO	J:164563
Biological Process	GO:0006536	glutamate metabolic process	ISO	J:164563
Biological Process	GO:0006750	glutathione biosynthetic process	ISO	J:155856
Biological Process	GO:0006750	glutathione biosynthetic process	ISO	J:164563
Biological Process	GO:0006750	glutathione biosynthetic process	IBA	J:265628
Biological Process	GO:0006750	glutathione biosynthetic process	IMP	J:62177
Biological Process	GO:0006750	glutathione biosynthetic process	IDA	J:102460
Biological Process	GO:0006749	glutathione metabolic process	IMP	J:66499
Biological Process	GO:0019852	L-ascorbic acid metabolic process	IMP	J:66499
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	IGI	J:91536
Biological Process	GO:2000490	negative regulation of hepatic stellate cell activation	ISO	J:155856
Biological Process	GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IGI	J:91536
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0031397	negative regulation of protein ubiquitination	IMP	J:117265
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP	J:117265
Biological Process	GO:0051900	regulation of mitochondrial depolarization	IGI	J:91536
Biological Process	GO:0046685	response to arsenic-containing substance	IMP	J:117265
Biological Process	GO:0009408	response to heat	ISO	J:164563
Biological Process	GO:0009725	response to hormone	ISO	J:164563
Biological Process	GO:0051409	response to nitrosative stress	ISO	J:155856
Biological Process	GO:0006979	response to oxidative stress	ISO	J:155856
Biological Process	GO:0006979	response to oxidative stress	ISO	J:164563
Biological Process	GO:0009410	response to xenobiotic stimulus	IMP	J:117265