GO Annotations Graph

• Symbol: Eps15
• Name: epidermal growth factor receptor pathway substrate 15
• ID: MGI:104583

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0042802	identical protein binding	IPI	J:200404
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0031593	polyubiquitin modification-dependent protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:113837
Molecular Function	GO:0005515	protein binding	IPI	J:220514
Molecular Function	GO:0005515	protein binding	IPI	J:200404
Molecular Function	GO:0005515	protein binding	IPI	J:190256
Molecular Function	GO:0005515	protein binding	IPI	J:163444
Molecular Function	GO:0005515	protein binding	IPI	J:168194
Molecular Function	GO:0017124	SH3 domain binding	IEA	J:60000
Cellular Component	GO:0016235	aggresome	ISO	J:164563
Cellular Component	GO:0030122	AP-2 adaptor complex	IDA	J:168194
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0009925	basal plasma membrane	ISO	J:155856
Cellular Component	GO:0060170	ciliary membrane	IDA	J:164083
Cellular Component	GO:0030132	clathrin coat of coated pit	IBA	J:265628
Cellular Component	GO:0030132	clathrin coat of coated pit	IDA	J:180119
Cellular Component	GO:0005905	clathrin-coated pit	IDA	J:164083
Cellular Component	GO:0030136	clathrin-coated vesicle	IDA	J:168194
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005769	early endosome	ISO	J:155856
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:168194
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0045202	synapse	ISO	J:155856
Biological Process	GO:0048268	clathrin coat assembly	ISO	J:164563
Biological Process	GO:0032456	endocytic recycling	ISO	J:155856
Biological Process	GO:0006897	endocytosis	IBA	J:265628
Biological Process	GO:0016197	endosomal transport	IBA	J:265628
Biological Process	GO:0006895	Golgi to endosome transport	ISO	J:164563
Biological Process	GO:0001921	positive regulation of receptor recycling	ISO	J:155856
Biological Process	GO:0098884	postsynaptic neurotransmitter receptor internalization	ISO	J:155856
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:0019065	receptor-mediated endocytosis of virus by host cell	ISO	J:164563
Biological Process	GO:0042127	regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0032880	regulation of protein localization	IMP	J:299316
Biological Process	GO:0046718	viral entry into host cell	ISO	J:164563