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GO Annotations Graph
Symbol
Name
ID
Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
MGI:103264

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0005085guanyl-nucleotide exchange factor activityIEAJ:60000
Molecular FunctionGO:0046872metal ion bindingIEAJ:60000
Molecular FunctionGO:0008017microtubule bindingISOJ:164563
Molecular FunctionGO:0008017microtubule bindingIDAJ:99758
Molecular FunctionGO:0005515protein bindingIPIJ:99758
Molecular FunctionGO:0005515protein bindingIPIJ:209645
Molecular FunctionGO:0005515protein bindingIPIJ:173122
Molecular FunctionGO:0048365Rac GTPase bindingISOJ:164563
Molecular FunctionGO:0030676Rac guanyl-nucleotide exchange factor activityISOJ:164563
Molecular FunctionGO:0017048Rho GTPase bindingISOJ:164563
Molecular FunctionGO:0005089Rho guanyl-nucleotide exchange factor activityISOJ:164563
Molecular FunctionGO:0005089Rho guanyl-nucleotide exchange factor activityIDAJ:99758
Cellular ComponentGO:0005923bicellular tight junctionIEAJ:60000
Cellular ComponentGO:0030054cell junctionIEAJ:60000
Cellular ComponentGO:0005737cytoplasmISOJ:164563
Cellular ComponentGO:0031410cytoplasmic vesicleIEAJ:60000
Cellular ComponentGO:0005856cytoskeletonISOJ:164563
Cellular ComponentGO:0043198dendritic shaftIDAJ:99758
Cellular ComponentGO:0005925focal adhesionISOJ:164563
Cellular ComponentGO:0005794Golgi apparatusIEAJ:60000
Cellular ComponentGO:0005874microtubuleISOJ:164563
Cellular ComponentGO:0043025neuronal cell bodyIDAJ:99758
Cellular ComponentGO:0097481neuronal postsynaptic densityIDAJ:187362
Cellular ComponentGO:0043234protein complexISOJ:164563
Cellular ComponentGO:0032587ruffle membraneISOJ:164563
Cellular ComponentGO:0031982vesicleISOJ:164563
Biological ProcessGO:0007015actin filament organizationISOJ:164563
Biological ProcessGO:0007015actin filament organizationIPIJ:99758
Biological ProcessGO:0007049cell cycleIEAJ:60000
Biological ProcessGO:0051301cell divisionIEAJ:60000
Biological ProcessGO:0000902cell morphogenesisISOJ:164563
Biological ProcessGO:0000902cell morphogenesisIDAJ:99758
Biological ProcessGO:0071225cellular response to muramyl dipeptideISOJ:164563
Biological ProcessGO:0000132establishment of mitotic spindle orientationIMPJ:161097
Biological ProcessGO:0002376immune system processIEAJ:60000
Biological ProcessGO:0045087innate immune responseIEAJ:60000
Biological ProcessGO:0035556intracellular signal transductionIEAJ:72247
Biological ProcessGO:0007067mitotic nuclear divisionIEAJ:60000
Biological ProcessGO:0007026negative regulation of microtubule depolymerizationISOJ:164563
Biological ProcessGO:0050768negative regulation of neurogenesisIMPJ:161097
Biological ProcessGO:0043547positive regulation of GTPase activityISOJ:164563
Biological ProcessGO:0032755positive regulation of interleukin-6 productionISOJ:164563
Biological ProcessGO:0051092positive regulation of NF-kappaB transcription factor activityISOJ:164563
Biological ProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationISOJ:164563
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterISOJ:164563
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionISOJ:164563
Biological ProcessGO:0035023regulation of Rho protein signal transductionIDAJ:99758


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory