GO Annotations Graph

• Symbol: Cst3
• Name: cystatin C
• ID: MGI:102519

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:164563
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity	ISO	J:164563
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity	IBA	J:265628
Molecular Function	GO:0004866	endopeptidase inhibitor activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0030414	peptidase inhibitor activity	ISO	J:164563
Molecular Function	GO:0030414	peptidase inhibitor activity	ISO	J:155856
Molecular Function	GO:0002020	protease binding	ISO	J:155856
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0005604	basement membrane	ISO	J:155856
Cellular Component	GO:0042995	cell projection	ISO	J:155856
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265607
Cellular Component	GO:0043292	contractile fiber	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISO	J:155856
Cellular Component	GO:0005771	multivesicular body	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0031965	nuclear membrane	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0031982	vesicle	ISO	J:155856
Cellular Component	GO:0031982	vesicle	IBA	J:265628
Biological Process	GO:0006952	defense response	ISO	J:164563
Biological Process	GO:0060313	negative regulation of blood vessel remodeling	ISO	J:164563
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:155856
Biological Process	GO:0010711	negative regulation of collagen catabolic process	ISO	J:164563
Biological Process	GO:2000117	negative regulation of cysteine-type endopeptidase activity	IBA	J:265628
Biological Process	GO:0060311	negative regulation of elastin catabolic process	ISO	J:164563
Biological Process	GO:0010716	negative regulation of extracellular matrix disassembly	ISO	J:164563
Biological Process	GO:0010466	negative regulation of peptidase activity	ISO	J:164563
Biological Process	GO:0045861	negative regulation of proteolysis	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0045740	positive regulation of DNA replication	ISO	J:155856
Biological Process	GO:0043067	regulation of programmed cell death	ISO	J:155856
Biological Process	GO:0034103	regulation of tissue remodeling	ISO	J:164563
Biological Process	GO:0006979	response to oxidative stress	ISO	J:155856
Biological Process	GO:0097435	supramolecular fiber organization	ISO	J:164563