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Epha3 Gene Detail
Summary
  • Symbol
    Epha3
  • Name
    Eph receptor A3
  • Synonyms
    Cek4, End3, Hek, Hek4, Mek4, Tyro4
  • Feature Type
    protein coding gene
  • IDs
    MGI:99612
    NCBI Gene: 13837
  • Gene Overview
    MyGene.info: EPHA3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:63545218-63864157 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      318940 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 36.49 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    EPHA3, EPH receptor A3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EPHA3, EPH receptor A3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EK4, ETK, ETK1, HEK, HEK4, TYRO4
  • Links
    NCBI Gene ID: 2042
    neXtProt AC: NX_P29320
    UniProt: P29320

  • Chr Location
    3p11.1; chr3:89107524-89482134 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene usually die within 48 hours of birth of cardiac failure. Survivors develop normally with no indications of cardiac abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13837 NCBI Gene Model | MGI Sequence Detail 318940 C57BL/6J ±  kb
    transcript NM_001362452 RefSeq | MGI Sequence Detail 5692 C57BL/6  
    polypeptide P29319 UniProt | EBI | MGI Sequence Detail 983 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2493 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • EC
    • InterPro Domains
      IPR001090 Ephrin receptor ligand binding domain
      IPR027936 Ephrin receptor, transmembrane domain
      IPR016257 Ephrin receptor type-A /type-B
      IPR034266 Ephrin type-A receptor 3, ligand binding domain
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR008979 Galactose-binding-like domain superfamily
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
      IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
    Molecular
    Reagents
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    • All nucleic 100
      Genomic 1
      cDNA 88
      Primer pair 10
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16397, MGI:2146641, MGI:2662731
    References
    more
    • Summaries
      All 120
      Developmental Gene Expression 73
      Gene Ontology 11
      Phenotypes 10
    • Earliest
      J:17817 Sajjadi FG, et al., Identification of a new eph-related receptor tyrosine kinase gene from mouse and chicken that is developmentally regulated and encodes at least two forms of the receptor. New Biol. 1991 Aug;3(8):769-78
    • Latest
      J:255884 Laurent F, et al., HAND2 Target Gene Regulatory Networks Control Atrioventricular Canal and Cardiac Valve Development. Cell Rep. 2017 May 23;19(8):1602-1613

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory