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Epha3 Gene Detail
Summary
  • Symbol
    Epha3
  • Name
    Eph receptor A3
  • Synonyms
    Cek4, End3, Hek, Hek4, Mek4, Tyro4
  • Feature Type
    protein coding gene
  • IDs
    MGI:99612
    NCBI Gene: 13837
  • Gene Overview
    MyGene.info: EPHA3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:63543534-63864175 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 36.49 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2499 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99612
protein coding gene Chr16:63543532-63864175 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022938
protein coding gene Chr16:62990802-63325086 (-)
A/J MGP_AJ_G0022906
protein coding gene Chr16:60298639-60619177 (-)
AKR/J MGP_AKRJ_G0022876
protein coding gene Chr16:62175780-62503628 (-)
BALB/cJ MGP_BALBcJ_G0022908
protein coding gene Chr16:60486299-60811765 (-)
C3H/HeJ MGP_C3HHeJ_G0022670
protein coding gene Chr16:62470662-62795996 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023356
protein coding gene Chr16:64865403-65212209 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020859
protein coding gene Chr16:59437406-59741994 (-)
CAST/EiJ MGP_CASTEiJ_G0022194
protein coding gene Chr16:62698192-63040962 (-)
CBA/J MGP_CBAJ_G0022641
protein coding gene Chr16:67567390-67932999 (-)
DBA/2J MGP_DBA2J_G0022773
protein coding gene Chr16:60067484-60389057 (-)
FVB/NJ MGP_FVBNJ_G0022747
protein coding gene Chr16:59695653-60011363 (-)
LP/J MGP_LPJ_G0022842
protein coding gene Chr16:62793360-63143291 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022766
protein coding gene Chr16:68648891-69097857 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023372
protein coding gene Chr16:62252251-62587051 (-)
PWK/PhJ MGP_PWKPhJ_G0021936
protein coding gene Chr16:60244995-60568766 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021766
protein coding gene Chr16:61989742-62315394 (-)
WSB/EiJ MGP_WSBEiJ_G0022240
protein coding gene Chr16:62323700-62664547 (-)



Homology
more
  • Human Ortholog
    EPHA3, EPH receptor A3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EPHA3, EPH receptor A3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EK4, ETK, ETK1, HEK, HEK4, TYRO4
  • Links
    NCBI Gene ID: 2042
    neXtProt AC: NX_P29320
    UniProt: P29320

  • Chr Location
    3p11.1; chr3:89107524-89482134 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene usually die within 48 hours of birth of cardiac failure. Survivors develop normally with no indications of cardiac abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052504 Ensembl Gene Model | MGI Sequence Detail 320642 C57BL/6J ±  kb
    transcript ENSMUST00000064405 Ensembl | MGI Sequence Detail 5663 Not Applicable  
    polypeptide ENSMUSP00000066554 Ensembl | MGI Sequence Detail 984 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000007123 ephrin type-A receptor 3
    • EC
    • InterPro Domains
      IPR001090 Ephrin receptor ligand binding domain
      IPR027936 Ephrin receptor, transmembrane domain
      IPR016257 Ephrin receptor type-A /type-B
      IPR034266 Ephrin type-A receptor 3, ligand binding domain
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR008979 Galactose-binding-like domain superfamily
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
      IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
    Molecular
    Reagents
    less
    • All nucleic 104
      Genomic 1
      cDNA 90
      Primer pair 12
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16397, MGI:2146641, MGI:2662731
    References
    more
    • Summaries
      All 126
      Developmental Gene Expression 76
      Gene Ontology 12
      Phenotypes 12
    • Earliest
      J:17817 Sajjadi FG, et al., Identification of a new eph-related receptor tyrosine kinase gene from mouse and chicken that is developmentally regulated and encodes at least two forms of the receptor. New Biol. 1991 Aug;3(8):769-78
    • Latest
      J:274472 Andretta E, et al., Investigation of the role of tyrosine kinase receptor EPHA3 in colorectal cancer. Sci Rep. 2017 Feb 7;7:41576

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory