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Gene Detail
Eph receptor A3
Synonyms Cek4, End3, Hek, Hek4, Mek4, Tyro4
Feature Type protein coding gene
Genetic Map
Chromosome 16
36.49 cM
Detailed Genetic Map ± 1 cM

Mapping data(3)
Sequence Map
Chr16:63545218-63864157 bp, - strand
From NCBI annotation of GRCm38

  318940 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:21083  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: tyrosine-protein kinase, ephrin receptor type
Gene Tree: Epha3

Human Homolog EPHA3, EPH receptor A3
NCBI Gene ID 2042
neXtProt AC  NX_P29320
Human Synonyms  EK4, ETK, ETK1, HEK, HEK4, TYRO4
Human Chr (Location)  3p11.2; chr3:89107524-89482134 (+)  GRCh38
alleles, and
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for disruptions in this gene usually die within 48 hours of birth of cardiac failure. Survivors develop normally with no indications of cardiac abnormalities.
Epha3 interacts with 373 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (37 annotations)
Process cell migration, cellular response to retinoic acid, ...
Component early endosome, extracellular region, ...
Function ATP binding, ephrin receptor activity, ...
External Resources: FuncBase
Literature Summary: (58 records)
Data Summary: Results (574)    Tissues (248)    Images (105)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 27, 28
Assay TypeResults
Immunohistochemistry 10
RNA in situ 529
Northern blot 8
cDNA source data(79)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(92) Genomic(1) cDNA(81) Primer pair(9) Other(1)
Microarray probesets(6)
Other database
Ensembl Gene ModelENSMUSG00000052504 (Evidence)
Entrez Gene13837 (Evidence)
DFCITC1579798, TC1592476, TC1603432
DoTSDT.101269180, DT.484593
NIA Mouse Gene IndexU037171
Consensus CDS ProjectCCDS28264.1
International Mouse Knockout Project StatusEpha3
Representative SequencesLengthStrain/SpeciesFlank
genomic 13837 NCBI Gene Model | MGI Sequence Detail 318940 C57BL/6J ±  kb
transcript NM_010140 RefSeq | MGI Sequence Detail 3978 C57BL/6 
polypeptide P29319 UniProt | EBI | MGI Sequence Detail 983 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(2505 from dbSNP Build 137)
InterPro IPR001090 Ephrin receptor ligand binding domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011510 Sterile alpha motif, type 2
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016257 Tyrosine-protein kinase, ephrin receptor
InterPro IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
InterPro IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Protein Ontology PR:000007123 ephrin type-A receptor 3
Graphical View of Protein Domain Structure
References (Earliest) J:17817 Sajjadi FG, et al., Identification of a new eph-related receptor tyrosine kinase gene from mouse and chicken that is developmentally regulated and encodes at least two forms of the receptor. New Biol. 1991 Aug;3(8):769-78
(Latest) J:204470 Inagawa M, et al., Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis. Mech Dev. 2013 Nov-Dec;130(11-12):519-31
All references(104)
accession IDs
MGD-MRK-16397, MGI:2146641, MGI:2662731

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory