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Epha3 Gene Detail
Summary
  • Symbol
    Epha3
  • Name
    Eph receptor A3
  • Synonyms
    Cek4, End3, Hek, Hek4, Mek4, Tyro4
  • Feature Type
    protein coding gene
  • IDs
    MGI:99612
    NCBI Gene: 13837
  • Gene Overview
    MyGene.info: EPHA3
Location & Maps
more
  • Sequence Map
    Chr16:63545218-63864157 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      318940 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 36.49 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    EPHA3, EPH receptor A3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EPHA3, EPH receptor A3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EK4, ETK, ETK1, HEK, HEK4, TYRO4
  • Links
    NCBI Gene ID: 2042
    neXtProt AC: NX_P29320

  • Chr Location
    3p11.2; chr3:89107524-89482134 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene usually die within 48 hours of birth of cardiac failure. Survivors develop normally with no indications of cardiac abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13837 NCBI Gene Model | MGI Sequence Detail 318940 C57BL/6J ±  kb
transcript NM_010140 RefSeq | MGI Sequence Detail 3978 C57BL/6  
polypeptide P29319 UniProt | EBI | MGI Sequence Detail 983 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2493 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000007123 ephrin type-A receptor 3
  • EC
  • InterPro Domains
    IPR001090 Ephrin receptor ligand binding domain
    IPR027936 Ephrin receptor, transmembrane domain
    IPR016257 Ephrin receptor type-A /type-B
    IPR003961 Fibronectin type III
    IPR008979 Galactose-binding domain-like
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR013783 Immunoglobulin-like fold
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain
    IPR008266 Tyrosine-protein kinase, active site
    IPR020635 Tyrosine-protein kinase, catalytic domain
    IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
    IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Molecular
Reagents
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  • All nucleic 96
    Genomic 1
    cDNA 84
    Primer pair 10
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-16397, MGI:2146641, MGI:2662731
References
more
  • Summaries
    All 109
    Developmental Gene Expression 66
    Gene Ontology 11
    Phenotypes 10
  • Earliest
    J:17817 Sajjadi FG, et al., Identification of a new eph-related receptor tyrosine kinase gene from mouse and chicken that is developmentally regulated and encodes at least two forms of the receptor. New Biol. 1991 Aug;3(8):769-78
  • Latest
    J:231672 Xavier GM, et al., Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue. Front Physiol. 2016;7:60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory