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Smarca2
Gene Detail
Symbol

Name
ID
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
MGI:99603
Synonyms
2610209L14Rik, brm, Snf2l2
Feature Type
protein coding gene
Genetic Map
Chromosome 19
21.17 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:26605115-26778321 bp, + strand
From VEGA annotation of GRCm38

  173207 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2308  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SMARCA2
Protein SuperFamily: SNF2-family ATP-dependent chromatin remodeling factor
Gene Tree: Smarca2

Human
homologs
SMARCA2, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6595
neXtProt AC: NX_P51531

Human Synonyms: BAF190, BRM, hBRM, hSNF2a, NCBRS, SNF2, SNF2L2, SNF2LA, Sth1p, SWI2

Human Chr (Location): 9p22.3; chr9:2015219-2193624 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SMARCA2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted mutation in this gene may exhibit infertility and a slightly increased body weight in some genetic backgrounds.
 
Interactions
Smarca2 interacts with 241 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process aortic smooth muscle cell differentiation, chromatin organization, ...
Component BAF-type complex, intermediate filament cytoskeleton, ...
Function ATPase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (182)    Tissues (65)    Images (66)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 24
RNA in situ 107
Western blot 36
RT-PCR 15
cDNA source data(118)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase smarca2    NEW 
Molecular
reagents
All nucleic(125) cDNA(122) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000040069 (Evidence)
Ensembl Gene Model ENSMUSG00000024921 (Evidence)
Entrez Gene 67155 (Evidence)
UniGene 491146
DoTS DT.110852697, DT.40168140, DT.50317038, DT.55147957, DT.94371121
NIA Mouse Gene Index U043718
EC 3.6.4.-
Consensus CDS Project CCDS29720.1, CCDS37945.1
International Mouse Phenotyping Consortium Status Smarca2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040069 VEGA Gene Model | MGI Sequence Detail 173207 C57BL/6J ±  kb
transcript OTTMUST00000104061 VEGA | MGI Sequence Detail 5862 Not Applicable 
polypeptide OTTMUSP00000058196 VEGA | MGI Sequence Detail 1601 Not Applicable 

For the selected sequences
All sequences(136) RefSeq(23) UniProt(20)
Polymorphisms
RFLP(1) : SNPs within 2kb(1239 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006576 BRK domain
InterPro IPR001487 Bromodomain
InterPro IPR018359 Bromodomain, conserved site
InterPro IPR014978 Glutamine-Leucine-Glutamine, QLQ
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014012 Helicase/SANT-associated domain
InterPro IPR014001 Helicase superfamily 1/2, ATP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR029295 Snf2 ATP coupling domain
InterPro IPR000330 SNF2-related, N-terminal domain
InterPro IPR030088 SWI/SNF complex subunit SMARCA2
Protein Ontology PR:000029762 global transcription activator SNF2L2
References
(Earliest) J:11178 Spies T, et al., Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter [see comments]. Nature. 1991 May 23;351(6324):323-4
(Latest) J:218900 Bischof M, et al., Brg1-dependent chromatin remodelling is not essentially required during oligodendroglial differentiation. J Neurosci. 2015 Jan 7;35(1):21-35
All references(77)
Other
accession IDs
MGD-MRK-16388, MGI:1914405

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory