About   Help   FAQ
Smarca2
Gene Detail
Symbol

Name
ID
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
MGI:99603
Synonyms
2610209L14Rik, brm, Snf2l2
Feature Type
protein coding gene
Genetic Map
Chromosome 19
21.17 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:26605115-26778321 bp, + strand
From VEGA annotation of GRCm38

  173207 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2308  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: SNF2-family ATP-dependent chromatin remodeling factor
Gene Tree: Smarca2

Human
homologs
Human Homolog SMARCA2, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
NCBI Gene ID 6595
neXtProt AC  NX_P51531
Human Synonyms  BAF190, BRM, hBRM, hSNF2a, NCBRS, SNF2, SNF2L2, SNF2LA, Sth1p, SWI2
Human Chr (Location)  9p22.3; chr9:2015219-2193624 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SMARCA2
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation in this gene may exhibit infertility and a slightly increased body weight in some genetic backgrounds.
 
Interactions
Smarca2 interacts with 242 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (19 records)
Data Summary: Results (182)    Tissues (65)    Images (66)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 24
RNA in situ 107
Western blot 36
RT-PCR 15
cDNA source data(118)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(125) cDNA(122) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000040069 (Evidence)
Ensembl Gene ModelENSMUSG00000024921 (Evidence)
Entrez Gene67155 (Evidence)
UniGene491146
DoTSDT.40168140, DT.94371121, DT.110852697, DT.55147957, DT.50317038
NIA Mouse Gene IndexU043718
EC3.6.4.-
Consensus CDS ProjectCCDS29720.1, CCDS37945.1
International Mouse Knockout Project StatusSmarca2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040069 VEGA Gene Model | MGI Sequence Detail 173207 C57BL/6J ±  kb
transcript OTTMUST00000104061 VEGA | MGI Sequence Detail 5862 Not Applicable 
polypeptide OTTMUSP00000058196 VEGA | MGI Sequence Detail 1601 Not Applicable 

For the selected sequences
All sequences(158) RefSeq(27) UniProt(39)
Polymorphisms
RFLP(1) : SNPs within 2kb(1239 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006576 BRK domain
InterPro IPR001487 Bromodomain
InterPro IPR018359 Bromodomain, conserved site
InterPro IPR014978 Glutamine-Leucine-Glutamine, QLQ
InterPro IPR013999 HAS subgroup
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014012 Helicase/SANT-associated, DNA binding
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000330 SNF2-related
Protein Ontology PR:000029762 global transcription activator SNF2L2
References
(Earliest) J:11178 Spies T, et al., Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter [see comments]. Nature. 1991 May 23;351(6324):323-4
(Latest) J:212358 Singh AP, et al., Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation. Nucleic Acids Res. 2014 Mar;42(5):2958-75
All references(75)
Other
accession IDs
MGD-MRK-16388, MGI:1914405

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/11/2014
MGI 5.20
The Jackson Laboratory