Smarca2
Gene Detail

Symbol Name ID

Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 MGI:99603

Synonyms

2610209L14Rik, brm, Snf2l2

Feature Type

protein coding gene

Genetic Map

Chromosome 19

21.17 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr19:26605115-26778321 bp, + strand From VEGA annotation of GRCm38   173207 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2308  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: SNF2-family ATP-dependent chromatin remodeling factor
Gene Tree: Smarca2

Human homologs

Human Homolog		SMARCA2, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
NCBI Gene ID		6595
neXtProt AC		NX_P51531
Human Synonyms		BAF190, BRM, hBRM, hSNF2a, NCBRS, SNF2, SNF2L2, SNF2LA, Sth1p, SWI2
Human Chr (Location)		9p22.3; chr9:2015342-2193624 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SMARCA2

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Mice homozygous for a targeted mutation in this gene may exhibit infertility and a slightly increased body weight in some genetic backgrounds.

 

Gene Ontology (GO) classifications

All GO classifications: (37 annotations)

Process	aortic smooth muscle cell differentiation, chromatin organization, ...
Component	intermediate filament cytoskeleton, intracellular membrane-bounded organelle, ...
Function	ATP binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (186)    Tissues (69)    Images (66)
Theiler Stages: 2, 3, 4, 5, 8, 11, 12, 13, 14, 17, 20, 23, 26, 28

Assay Type	Results
Immunohistochemistry	24
RNA in situ	104
Western blot	36
RT-PCR	22

cDNA source data(116)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(123) cDNA(120) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000040069 (Evidence)
Ensembl Gene Model	ENSMUSG00000024921 (Evidence)
Entrez Gene	67155 (Evidence)
UniGene	485812
DoTS	DT.110852697, DT.40168140, DT.50317038, DT.55147957, DT.94371121
NIA Mouse Gene Index	U043718
EC	3.6.4.-
Consensus CDS Project	CCDS29720.1, CCDS37945.1
International Mouse Knockout Project Status	Smarca2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000040069	VEGA Gene Model | MGI Sequence Detail	173207	C57BL/6J
transcript	OTTMUST00000104061	VEGA | MGI Sequence Detail	5862	Not Applicable
polypeptide	OTTMUSP00000058196	VEGA | MGI Sequence Detail	1601	Not Applicable

All sequences(116) RefSeq(4) UniProt(20)

Polymorphisms

RFLP(1) : SNPs(938 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006576	BRK domain
InterPro	IPR001487	Bromodomain
InterPro	IPR018359	Bromodomain, conserved site
InterPro	IPR014978	Glutamine-Leucine-Glutamine, QLQ
InterPro	IPR013999	HAS subgroup
InterPro	IPR001650	Helicase, C-terminal
InterPro	IPR014012	Helicase/SANT-associated, DNA binding
InterPro	IPR014001	Helicase, superfamily 1/2, ATP-binding domain
InterPro	IPR006562	HSA
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR000330	SNF2-related
Protein Ontology	PR:000029762	global transcription activator SNF2L2

References

(Earliest) J:11178 Spies T, et al., Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter [see comments]. Nature. 1991 May 23;351(6324):323-4
(Latest) J:194321 Nott A, et al., S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3113-8
All references(69)

Other accession IDs

MGD-MRK-16388, MGI:1914405