Ltbp2
Gene Detail

Symbol Name ID

Ltbp2 latent transforming growth factor beta binding protein 2 MGI:99502

Feature Type

protein coding gene

Genetic Map

Chromosome 12

39.39 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr12:84783212-84876532 bp, - strand From VEGA annotation of GRCm38   93321 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:369  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: latent transforming growth factor beta-binding protein
Gene Tree: Ltbp2

Human homologs

Human Homolog		LTBP2, latent transforming growth factor beta binding protein 2
NCBI Gene ID		4053
neXtProt AC		NX_Q14767
Human Synonyms		C14orf141, GLC3D, LTBP3, MSPKA, MSTP031, WMS3
Human Chr (Location)		14q24; chr14:74964886-75079034 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human LTBP2

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for disruptions in this gene die as embryos sometime around the time of implantation.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	biological_process
Component	extracellular matrix, extracellular region, ...
Function	calcium ion binding, growth factor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (94)    Tissues (32)    Images (24)
Theiler Stages: 23, 24

Assay Type	Results
RNA in situ	94

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(28) Genomic(1) cDNA(27)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000036546 (Evidence)
Ensembl Gene Model	ENSMUSG00000002020 (Evidence)
Entrez Gene	16997 (Evidence)
UniGene	3900
DFCI	TC1582227
Consensus CDS Project	CCDS49112.1
International Mouse Knockout Project Status	Ltbp2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036546	VEGA Gene Model | MGI Sequence Detail	93321	C57BL/6J
transcript	OTTMUST00000093715	VEGA | MGI Sequence Detail	6769	Not Applicable
polypeptide	OTTMUSP00000052053	VEGA | MGI Sequence Detail	1809	Not Applicable

All sequences(42) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(543 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR009030	Growth factor, receptor
InterPro	IPR017878	TB domain
Protein Ontology	PR:000009973	latent-transforming growth factor beta-binding protein 2

References

(Earliest) J:37693 Nakajima Y, et al., Extracellular fibrillar structure of latent TGF beta binding protein-1: role in TGF beta-dependent endothelial-mesenchymal transformation during endocardial cushion tissue formation in mouse embryonic heart. J Cell Biol. 1997 Jan 13;136(1):193-204
(Latest) J:184521 Koss M, et al., Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
All references(32)

Other accession IDs

MGD-MRK-16278, MGI:2145013