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Ltbp2
Gene Detail
Symbol

Name
ID
Ltbp2
latent transforming growth factor beta binding protein 2
MGI:99502
Feature Type
protein coding gene
Genetic Map
Chromosome 12
39.39 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:84783212-84876532 bp, - strand
From VEGA annotation of GRCm38

  93321 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:369  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: LTBP2
Protein SuperFamily: latent transforming growth factor beta-binding protein
Gene Tree: Ltbp2

Human
homologs
LTBP2, latent transforming growth factor beta binding protein 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4053
neXtProt AC: NX_Q14767

Human Synonyms: C14orf141, GLC3D, LTBP3, MSPKA, MSTP031, WMS3

Human Chr (Location): 14q24; chr14:74498183-74618609 (-)  GRCh38.p2

Disease Associations: (4) Diseases Associated with Human LTBP2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Ltbp2 interacts with 177 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process extracellular fibril organization
Component extracellular exosome, extracellular matrix, ...
Function calcium ion binding, growth factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (94)    Tissues (32)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(26)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000036546 (Evidence)
Ensembl Gene Model ENSMUSG00000002020 (Evidence)
Entrez Gene 16997 (Evidence)
UniGene 3900
DFCI TC1582227
Consensus CDS Project CCDS49112.1
International Mouse Phenotyping Consortium Status Ltbp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036546 VEGA Gene Model | MGI Sequence Detail 93321 C57BL/6J ±  kb
transcript OTTMUST00000093715 VEGA | MGI Sequence Detail 6769 Not Applicable 
polypeptide OTTMUSP00000052053 VEGA | MGI Sequence Detail 1809 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(8) UniProt(7)
Polymorphisms
SNPs within 2kb(550 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR001881 EGF-like calcium-binding domain
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 EGF-like domain
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017878 TB domain
Protein Ontology PR:000009973 latent-transforming growth factor beta-binding protein 2
References
(Earliest) J:37693 Nakajima Y, et al., Extracellular fibrillar structure of latent TGF beta binding protein-1: role in TGF beta-dependent endothelial-mesenchymal transformation during endocardial cushion tissue formation in mouse embryonic heart. J Cell Biol. 1997 Jan 13;136(1):193-204
(Latest) J:214736 Inoue T, et al., Latent TGF-beta binding protein-2 is essential for the development of ciliary zonule microfibrils. Hum Mol Genet. 2014 Nov 1;23(21):5672-82
All references(32)
Other
accession IDs
MGD-MRK-16278, MGI:2145013

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory