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Vip Gene Detail
Summary
  • Symbol
    Vip
  • Name
    vasoactive intestinal polypeptide
  • Synonyms
    PHI, peptide histidine isoleucine
  • Feature Type
    protein coding gene
  • IDs
    MGI:98933
    NCBI Gene: 22353
  • Gene Overview
    MyGene.info: VIP
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:5639218-5647617 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8400 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 1.97 cM, cytoband A1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    VIP, vasoactive intestinal peptide
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VIP, vasoactive intestinal peptide
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PHM27
  • Links
    NCBI Gene ID: 7432
    neXtProt AC: NX_P01282
    UniProt: P01282

  • Chr Location
    6q25.2; chr6:152747894-152759765 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2539
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: VIP
  • Protein SuperFamily
  • Gene Tree
    Vip
Human Diseases
more
  • Diseases
    1 with Vip mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 4 genetic backgrounds
    93 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants display abnormal circadian rhythyms with a shorter period, abnormal phase, and in 1/4 arrhythmic circadian persistence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019772 Ensembl Gene Model | MGI Sequence Detail 8400 C57BL/6J ±  kb
    transcript ENSMUST00000019906 Ensembl | MGI Sequence Detail 1530 Not Applicable  
    polypeptide ENSMUSP00000019906 Ensembl | MGI Sequence Detail 171 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      87 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR000532 Glucagon/GIP/secretin/VIP
      IPR015523 Vasoactive intestinal peptide
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 4
      cDNA 11
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15398
    References
    more
    • Summaries
      All 194
      Developmental Gene Expression 54
      Diseases 1
      Gene Ontology 6
      Phenotypes 93
    • Earliest
      J:11160 Lamperti ED, et al., Characterization of the gene and messages for vasoactive intestinal polypeptide (VIP) in rat and mouse. Brain Res Mol Brain Res. 1991 Feb;9(3):217-31
    • Latest
      J:258041 Takesian AE, et al., Inhibitory circuit gating of auditory critical-period plasticity. Nat Neurosci. 2018 Feb;21(2):218-227

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory