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Vip
Gene Detail
Symbol

Name
ID
Vip
vasoactive intestinal polypeptide
MGI:98933
Synonyms
PHI, peptide histidine isoleucine
Feature Type
protein coding gene
Genetic Map
Chromosome 10
1.97 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:5639218-5647614 bp, + strand
From Ensembl annotation of GRCm38

  8397 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2539  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: VIP
Protein SuperFamily: glucagon
Gene Tree: Vip

Human
homologs
VIP, vasoactive intestinal peptide
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7432
neXtProt AC: NX_P01282

Human Synonyms: PHM27

Human Chr (Location): 6q25; chr6:152747923-152759765 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants display abnormal circadian rhythyms with a shorter period, abnormal phase, and in 1/4 arrhythmic circadian persistence.
 
Human Diseases Modeled in Mice Using Vip (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Vip interacts with 196 markers (Mir1b, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process learning or memory, negative regulation of apoptotic process, ...
Component extracellular region, neuronal cell body
Function hormone activity, receptor binding
External Resources: FuncBase
Expression
Literature Summary: (44 records)
Data Summary: Results (212)    Tissues (194)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 17
RNA in situ 149
RT-PCR 46
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase vip ; ZFIN vip    NEW 
Molecular
reagents
All nucleic(17) Genomic(4) cDNA(10) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000019772 (Evidence)
Entrez Gene 22353 (Evidence)
UniGene 98916
DFCI TC1581154
DoTS DT.50315250, DT.94193043, DT.99843813
NIA Mouse Gene Index U011234
Consensus CDS Project CCDS56682.1
International Mouse Phenotyping Consortium Status Vip
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019772 Ensembl Gene Model | MGI Sequence Detail 8397 C57BL/6J ±  kb
transcript ENSMUST00000019906 Ensembl | MGI Sequence Detail 1527 Not Applicable 
polypeptide ENSMUSP00000019906 Ensembl | MGI Sequence Detail 171 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(86 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000532 Glucagon/GIP/secretin/VIP
InterPro IPR015523 Vasoactive intestinal peptide
Protein Ontology PR:000017299 VIP peptides
References
(Earliest) J:11160 Lamperti ED, et al., Characterization of the gene and messages for vasoactive intestinal polypeptide (VIP) in rat and mouse. Brain Res Mol Brain Res. 1991 Feb;9(3):217-31
(Latest) J:218970 Fan J, et al., Vasoactive intestinal polypeptide (VIP)-expressing neurons in the suprachiasmatic nucleus provide sparse GABAergic outputs to local neurons with circadian regulation occurring distal to the opening of postsynaptic GABAA ionotropic receptors. J Neurosci. 2015 Feb 4;35(5):1905-20
All references(136)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-15398

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory