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Vip Gene Detail
Summary
  • Symbol
    Vip
  • Name
    vasoactive intestinal polypeptide
  • Synonyms
    PHI, peptide histidine isoleucine
  • Feature Type
    protein coding gene
  • IDs
    MGI:98933
    NCBI Gene: 22353
  • Gene Overview
    MyGene.info: VIP
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:5639218-5647617 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 1.97 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98933
protein coding gene Chr10:5639193-5647617 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016985
protein coding gene Chr10:2721872-2730270 (+)
A/J MGP_AJ_G0016963
protein coding gene Chr10:2563262-2571656 (+)
AKR/J MGP_AKRJ_G0016928
protein coding gene Chr10:2574155-2582554 (+)
BALB/cJ MGP_BALBcJ_G0016921
protein coding gene Chr10:2540765-2549156 (+)
C3H/HeJ MGP_C3HHeJ_G0016746
protein coding gene Chr10:2703593-2711989 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017384
protein coding gene Chr10:2765202-2773598 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015090
protein coding gene Chr10:2330251-2338666 (+)
CAST/EiJ MGP_CASTEiJ_G0016328
protein coding gene Chr10:2737634-2746037 (+)
CBA/J MGP_CBAJ_G0016718
protein coding gene Chr10:2889339-2897733 (+)
DBA/2J MGP_DBA2J_G0016826
protein coding gene Chr10:2549870-2558278 (+)
FVB/NJ MGP_FVBNJ_G0016821
protein coding gene Chr10:2502530-2510926 (+)
LP/J MGP_LPJ_G0016901
protein coding gene Chr10:2650471-2658868 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016852
protein coding gene Chr10:2743090-2751662 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017421
protein coding gene Chr10:2616297-2624694 (+)
PWK/PhJ MGP_PWKPhJ_G0016114
protein coding gene Chr10:2561731-2570221 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015896
protein coding gene Chr10:2813037-2821445 (+)
WSB/EiJ MGP_WSBEiJ_G0016390
protein coding gene Chr10:2671319-2679710 (+)



Homology
more
  • Human Ortholog
    VIP, vasoactive intestinal peptide
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VIP, vasoactive intestinal peptide
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PHM27
  • Links
    NCBI Gene ID: 7432
    neXtProt AC: NX_P01282
    UniProt: P01282

  • Chr Location
    6q25.2; chr6:152747894-152759765 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2539
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: VIP
  • Protein SuperFamily
  • Gene Tree
    Vip
Human Diseases
more
  • Diseases
    1 with Vip mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    108 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants display abnormal circadian rhythyms with a shorter period, abnormal phase, and in 1/4 arrhythmic circadian persistence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019772 Ensembl Gene Model | MGI Sequence Detail 8400 C57BL/6J ±  kb
    transcript ENSMUST00000019906 Ensembl | MGI Sequence Detail 1530 Not Applicable  
    polypeptide ENSMUSP00000019906 Ensembl | MGI Sequence Detail 171 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR000532 Glucagon/GIP/secretin/VIP
      IPR015523 Vasoactive intestinal peptide
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 4
      cDNA 13
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15398
    References
    more
    • Summaries
      All 215
      Developmental Gene Expression 58
      Diseases 1
      Gene Ontology 8
      Phenotypes 108
    • Earliest
      J:11160 Lamperti ED, et al., Characterization of the gene and messages for vasoactive intestinal polypeptide (VIP) in rat and mouse. Brain Res Mol Brain Res. 1991 Feb;9(3):217-31
    • Latest
      J:265948 Cajigas I, et al., The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially Organizes Megabase Distant Genes in the Developing Forebrain. Mol Cell. 2018 Sep 20;71(6):956-972.e9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory