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Vip
Gene Detail
 Symbol
Name
ID
Vip
vasoactive intestinal polypeptide
MGI:98933
Synonyms PHI, peptide histidine isoleucine
Feature Type protein coding gene
Genetic Map
Chromosome 10
1.97 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:5639218-5647614 bp, + strand
From NCBI annotation of GRCm38

  8397 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2539  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: glucagon
Gene Tree: Vip

Human
homologs
Human Homolog VIP, vasoactive intestinal peptide
NCBI Gene ID 7432
neXtProt AC  NX_P01282
Human Synonyms  PHM27
Human Chr (Location)  6q25; chr6:152750376-152759765 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants display abnormal circadian rhythyms with a shorter period, abnormal phase, and in 1/4 arrhythmic circadian persistence.
 
Human Diseases Modeled Using Mouse Vip (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Vip interacts with 196 markers (Mir1b, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process learning or memory, negative regulation of apoptotic process, ...
Component extracellular region, neuronal cell body
Function hormone activity, receptor binding
External Resources: FuncBase
Expression
Literature Summary: (42 records)
Data Summary: Results (213)    Tissues (195)    Images (32)
Theiler Stages: 21, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 17
RNA in situ 150
RT-PCR 46
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(4) cDNA(10) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000019772 (Evidence)
Entrez Gene22353 (Evidence)
UniGene98916
DFCITC1581154
DoTSDT.50315250, DT.94193043, DT.99843813
NIA Mouse Gene IndexU011234
Consensus CDS ProjectCCDS56682.1
International Mouse Knockout Project StatusVip
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22353 NCBI Gene Model | MGI Sequence Detail 8397 C57BL/6J ±  kb
transcript NM_011702 RefSeq | MGI Sequence Detail 1527 C57BL/6 
polypeptide P32648 UniProt | EBI | MGI Sequence Detail 170 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(10) UniProt(1)
Polymorphisms SNPs within 2kb(86 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000532 Glucagon/GIP/secretin/VIP
InterPro IPR015523 Vasoactive intestinal peptide
Protein Ontology PR:000017299 VIP peptides
Graphical View of Protein Domain Structure
References (Earliest) J:11160 Lamperti ED, et al., Characterization of the gene and messages for vasoactive intestinal polypeptide (VIP) in rat and mouse. Brain Res Mol Brain Res. 1991 Feb;9(3):217-31
(Latest) J:211630 Zhu Y, et al., Genetically targeted binary labeling of retinal neurons. J Neurosci. 2014 Jun 4;34(23):7845-61
All references(128)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-15398

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory