Tnnc1
Gene Detail

Symbol Name ID

Tnnc1 troponin C, cardiac/slow skeletal MGI:98779

STS

D14Mit13

Synonyms

cTnC, TnC

Feature Type

protein coding gene

Genetic Map

Chromosome 14

19.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:31208312-31211729 bp, + strand From VEGA annotation of GRCm38   3418 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55728  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tnnc1

Human homologs

Human Homolog		TNNC1, troponin C type 1 (slow)
NCBI Gene ID		7134
neXtProt AC		NX_P63316
Human Synonyms		CMD1Z, CMH13, TNC, TN-C, TNNC
Human Chr (Location)		3p21.1; chr3:52485107-52488057 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human TNNC1

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	cardiac muscle contraction, diaphragm contraction, ...
Component	contractile fiber, troponin complex
Function	actin filament binding, calcium-dependent protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (92)    Tissues (35)    Images (42)
Theiler Stages: 11, 12, 16, 17, 18, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	53
Northern blot	4
RT-PCR	35

cDNA source data(86)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(90) Genomic(1) cDNA(86) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035921 (Evidence)
Ensembl Gene Model	ENSMUSG00000091898 (Evidence)
Entrez Gene	21924 (Evidence)
UniGene	439921
DFCI	TC1578111
DoTS	DT.533517, DT.94383423
NIA Mouse Gene Index	U015459
Consensus CDS Project	CCDS36854.1
International Mouse Knockout Project Status	Tnnc1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035921	VEGA Gene Model | MGI Sequence Detail	3418	C57BL/6J
transcript	OTTMUST00000084259	VEGA | MGI Sequence Detail	721	Not Applicable
polypeptide	OTTMUSP00000045387	VEGA | MGI Sequence Detail	161	Not Applicable

All sequences(25) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(7 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018247	EF-Hand 1, calcium-binding site
InterPro	IPR002048	EF-hand domain
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR001125	Recoverin
Protein Ontology	PR:000016502	troponin C, slow skeletal and cardiac muscles

References

(Earliest) J:9901 Parmacek MS, et al., Structure and expression of the murine slow/cardiac troponin C gene. J Biol Chem. 1989 Aug 5;264(22):13217-25
(Latest) J:191565 Grote P, et al., The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse. Dev Cell. 2013 Jan 28;24(2):206-14
All references(59)

Other accession IDs

MGD-MRK-15149, MGI:2145705