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Tnnc1
Gene Detail
 Symbol
Name
ID
Tnnc1
troponin C, cardiac/slow skeletal
MGI:98779
STS D14Mit13
Synonyms cTnC, TnC
Feature Type protein coding gene
Genetic Map
Chromosome 14
19.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:31208312-31211729 bp, + strand
From VEGA annotation of GRCm38

  3418 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55728  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tnnc1

Human
homologs
Human Homolog TNNC1, troponin C type 1 (slow)
NCBI Gene ID 7134
neXtProt AC  NX_P63316
Human Synonyms  CMD1Z, CMH13, TNC, TN-C, TNNC
Human Chr (Location)  3p21.1; chr3:52451091-52454041 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human TNNC1
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Tnnc1 interacts with 22 markers (Mir22, Mir29b-2, Mir136, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cardiac muscle contraction, diaphragm contraction, ...
Component actin cytoskeleton, contractile fiber, ...
Function actin filament binding, calcium-dependent protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (164)    Tissues (107)    Images (44)
Theiler Stages: 11, 12, 16, 17, 18, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 125
Northern blot 4
RT-PCR 35
cDNA source data(86)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(90) Genomic(1) cDNA(86) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035921 (Evidence)
Ensembl Gene ModelENSMUSG00000091898 (Evidence)
Entrez Gene21924 (Evidence)
UniGene439921
DFCITC1578111
DoTSDT.533517, DT.94383423
NIA Mouse Gene IndexU015459
Consensus CDS ProjectCCDS36854.1
International Mouse Knockout Project StatusTnnc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035921 VEGA Gene Model | MGI Sequence Detail 3418 C57BL/6J ±  kb
transcript OTTMUST00000084259 VEGA | MGI Sequence Detail 721 Not Applicable 
polypeptide OTTMUSP00000045387 VEGA | MGI Sequence Detail 161 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
Protein Ontology PR:000016502 troponin C, slow skeletal and cardiac muscles
References (Earliest) J:9901 Parmacek MS, et al., Structure and expression of the murine slow/cardiac troponin C gene. J Biol Chem. 1989 Aug 5;264(22):13217-25
(Latest) J:191565 Grote P, et al., The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse. Dev Cell. 2013 Jan 28;24(2):206-14
All references(60)
Other
accession IDs
MGD-MRK-15149, MGI:2145705

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory