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Tnnc1 Gene Detail
Summary
  • Symbol
    Tnnc1
  • Name
    troponin C, cardiac/slow skeletal
  • Synonyms
    cTnC, TnC
  • Feature Type
    protein coding gene
  • IDs
    MGI:98779
    NCBI Gene: 21924
  • Gene Overview
    MyGene.info: TNNC1
Location & Maps
more
  • Sequence Map
    Chr14:31208312-31211729 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3418 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TNNC1, troponin C1, slow skeletal and cardiac type
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TNNC1, troponin C1, slow skeletal and cardiac type
    Orthology source: HomoloGene
  • Synonyms
    CMD1Z, CMH13, TNC, TN-C, TNNC
  • Links
    NCBI Gene ID: 7134
    neXtProt AC: NX_P63316

  • Chr Location
    3p21.1; chr3:52451091-52454041 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 55728
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TNNC1
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human TNNC1 associations

Human Disease Mouse Models
       Cardiomyopathy, Dilated, 1z; CMD1Z   OMIM: 611879
Cardiomyopathy, Familial Hypertrophic, 13; CMH13   OMIM: 613243
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035921 VEGA Gene Model | MGI Sequence Detail 3418 C57BL/6J ±  kb
transcript OTTMUST00000084259 VEGA | MGI Sequence Detail 721 Not Applicable  
polypeptide OTTMUSP00000045387 VEGA | MGI Sequence Detail 161 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    17 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000016502 troponin C, slow skeletal and cardiac muscles
  • InterPro Domains
    IPR018247 EF-Hand 1, calcium-binding site
    IPR002048 EF-hand domain
    IPR011992 EF-hand domain pair
Molecular
Reagents
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  • All nucleic 90
    Genomic 1
    cDNA 86
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-15149, MGI:2145705
References
more
  • Summaries
    All 60
    Developmental Gene Expression 23
    Gene Ontology 6
    Phenotypes 2
  • Earliest
    J:9901 Parmacek MS, et al., Structure and expression of the murine slow/cardiac troponin C gene. J Biol Chem. 1989 Aug 5;264(22):13217-25
  • Latest
    J:228946 Wei N, et al., SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing. Cell Rep. 2015 Nov 24;13(8):1647-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory