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Tnnc1
Gene Detail
Symbol

Name
ID
Tnnc1
troponin C, cardiac/slow skeletal
MGI:98779
STS
Synonyms
cTnC, TnC
Feature Type
protein coding gene
Genetic Map
Chromosome 14
19.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:31208312-31211729 bp, + strand
From VEGA annotation of GRCm38

  3418 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55728  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TNNC1
Gene Tree: Tnnc1

Human
homologs
TNNC1, troponin C type 1 (slow)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7134
neXtProt AC: NX_P63316

Human Synonyms: CMD1Z, CMH13, TNC, TN-C, TNNC

Human Chr (Location): 3p21.1; chr3:52451091-52454041 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TNNC1

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Tnnc1 interacts with 22 markers (Mir22, Mir29b-2, Mir136, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cardiac muscle contraction, diaphragm contraction, ...
Component actin cytoskeleton, contractile fiber, ...
Function actin filament binding, calcium-dependent protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (164)    Tissues (108)    Images (44)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 125
Northern blot 4
RT-PCR 35
cDNA source data(86)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TNNC1 ; Xenbase tnnc1 ; ZFIN tnnc1a, tnnc1b    NEW 
Molecular
reagents
All nucleic(90) Genomic(1) cDNA(86) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035921 (Evidence)
Ensembl Gene Model ENSMUSG00000091898 (Evidence)
Entrez Gene 21924 (Evidence)
UniGene 439921
DFCI TC1578111
DoTS DT.533517, DT.94383423
NIA Mouse Gene Index U015459
Consensus CDS Project CCDS36854.1
International Mouse Phenotyping Consortium Status Tnnc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035921 VEGA Gene Model | MGI Sequence Detail 3418 C57BL/6J ±  kb
transcript OTTMUST00000084259 VEGA | MGI Sequence Detail 721 Not Applicable 
polypeptide OTTMUSP00000045387 VEGA | MGI Sequence Detail 161 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
Protein Ontology PR:000016502 troponin C, slow skeletal and cardiac muscles
References
(Earliest) J:9901 Parmacek MS, et al., Structure and expression of the murine slow/cardiac troponin C gene. J Biol Chem. 1989 Aug 5;264(22):13217-25
(Latest) J:206589 Zhao C, et al., Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation. Development. 2014 Jan;141(2):281-95
All references(61)
Other
accession IDs
MGD-MRK-15149, MGI:2145705

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory