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Tcra-J Complex/Cluster/Region Detail
Summary
  • Symbol
    Tcra-J
  • Name
    T cell receptor alpha, joining region
  • Synonyms
    Jalpha281
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:98555
    NCBI Gene: 21475
Location & Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 14, Syntenic
  • Mapping Data
    1 experiment
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    44 phenotypes from 7 alleles in 8 genetic backgrounds
    10 phenotypes from multigenic genotypes
    1 images
    269 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Targeted
    11
Homozygotes with mutations in this locus have aberrant recombination of the Tcra gene segments that affects expression of the T-cell receptor.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
  • Other Mouse Links
Sequences &
Gene Models
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  • All Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic M38099 GenBank | EMBL | DDBJ | MGI Sequence Detail 701 B10.BR-H2 H2-T18/SgSnJ ±  kb
For the selected sequence
Molecular
Reagents
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  • All nucleic 131
    Genomic 57
    cDNA 69
    Other 5
Other
Accession IDs
less
MGD-MRK-14847
References
more
  • Summaries
    All 300
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 1
    Phenotypes 269
  • Earliest
    J:7626 Chien Y, et al., A third type of murine T-cell receptor gene. Nature. 1984 Nov 1-7;312(5989):31-5
  • Latest
    J:229696 Benoit P, et al., The role of CD1d-restricted NKT cells in the clearance of Pseudomonas aeruginosa from the lung is dependent on the host genetic background. Infect Immun. 2015 Jun;83(6):2557-65

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory