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srn Gene Detail
Summary
  • Symbol
    srn
  • Name
    siren
  • Feature Type
    heritable phenotypic marker
  • IDs
    MGI:98421
    NCBI Gene: 20812
  • Alliance
Location &
Maps
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  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome Unknown
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations in this gene result in fusion of the hindlimbs and other posterior defects resulting in neonatal lethality.
Sequences &
Gene Models
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Other
Accession IDs
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MGD-MRK-14601
References
more
  • Summaries
    All 8
    Phenotypes 7
  • Earliest
    J:5150 Hoornbeek FK, A gene producing symmelia in the mouse. Teratology. 1970 Feb;3(1):7-10
  • Latest
    J:6999 Orr BY, et al., Craniofacial, caudal, and visceral anomalies associated with mutant sirenomelic mice. Teratology. 1982 Dec;26(3):311-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory