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Sp1
Gene Detail
Symbol

Name
ID
Sp1
trans-acting transcription factor 1
MGI:98372
Synonyms
1110003E12Rik, Sp1-1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
57.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr15:102406143-102436404 bp, + strand
From VEGA annotation of GRCm38

  30262 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor, Sp1/Sp2/Sp3/Sp4 types
Gene Tree: Sp1

Human
homologs
Human Homolog SP1, Sp1 transcription factor
NCBI Gene ID 6667
neXtProt AC  NX_P08047
Human Chr (Location)  12q13.1; chr12:53380195-53416446 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(313) : Gene trapped(309) Radiation induced(1) Targeted(3)
Genomic Mutations involving Sp1 (1)
Incidental mutations (data from APF )
 
Homozygous null mice display reduced embryo size and die during organogenesis with a broad range of developmental defects. Heterozygous null mice are viable but slightly growth retarded, may lack one or both eyes, and show a decreased erythroid progenitor cell number in fetal liver cultures.
 
Interactions
Sp1 interacts with 518 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (26 records)
Data Summary: Results (213)    Tissues (167)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 141
Western blot 5
RT-PCR 44
RNase protection 23
cDNA source data(174)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(181) Genomic(2) cDNA(175) Primer pair(3) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000035159 (Evidence)
Ensembl Gene ModelENSMUSG00000001280 (Evidence)
Entrez Gene20683 (Evidence)
UniGene4618
DFCITC1579274, TC1589994, TC1602893, TC1631218, TC1633120
DoTSDT.101387053, DT.103551623, DT.485082, DT.491362
NIA Mouse Gene IndexU043484
Consensus CDS ProjectCCDS37229.1
International Mouse Knockout Project StatusSp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035159 VEGA Gene Model | MGI Sequence Detail 30262 C57BL/6J ±  kb
transcript OTTMUST00000089563 VEGA | MGI Sequence Detail 4081 Not Applicable 
polypeptide OTTMUSP00000048965 VEGA | MGI Sequence Detail 781 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(6) UniProt(6)
Polymorphisms
RFLP(7) : SNPs within 2kb(132 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000000133 transcription factor Sp1
References
(Earliest) J:10955 Dhir R, et al., Structural and functional characterization of the mouse multidrug resistance gene family. Bull Cancer (Paris). 1990;77(11):1125-9
(Latest) J:211629 Palazuelos J, et al., TGFbeta signaling regulates the timing of CNS myelination by modulating oligodendrocyte progenitor cell cycle exit through SMAD3/4/FoxO1/Sp1. J Neurosci. 2014 Jun 4;34(23):7917-30
All references(138)
Other
accession IDs
MGD-MRK-14512, MGI:1915735, MGI:2146073, MGI:3034478

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory