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Sp1
Gene Detail
Symbol

Name
ID
Sp1
trans-acting transcription factor 1
MGI:98372
Synonyms
1110003E12Rik, Sp1-1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
57.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr15:102406143-102436404 bp, + strand
From VEGA annotation of GRCm38

  30262 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SP1
Protein SuperFamily: transcription factor, Sp1/Sp2/Sp3/Sp4 types
Gene Tree: Sp1

Human
homologs
SP1, Sp1 transcription factor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6667
neXtProt AC: NX_P08047

Human Chr (Location): 12q13.1; chr12:53380195-53416446 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(313) : Gene trapped(309) Radiation induced(1) Targeted(3)
Genomic Mutations involving Sp1 (1)
Incidental mutations (data from APF , CvDC )
 
Homozygous null mice display reduced embryo size and die during organogenesis with a broad range of developmental defects. Heterozygous null mice are viable but slightly growth retarded, may lack one or both eyes, and show a decreased erythroid progenitor cell number in fetal liver cultures.
 
Phenotype Images(2)
Interactions
Sp1 interacts with 517 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (29 records)
Data Summary: Results (213)    Tissues (167)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 141
Western blot 5
RT-PCR 44
RNase protection 23
cDNA source data(174)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sp1 ; ZFIN sp1    NEW 
Molecular
reagents
All nucleic(181) Genomic(2) cDNA(175) Primer pair(3) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000035159 (Evidence)
Ensembl Gene Model ENSMUSG00000001280 (Evidence)
Entrez Gene 20683 (Evidence)
UniGene 4618
DFCI TC1579274, TC1633120, TC1631218, TC1589994, TC1602893
DoTS DT.485082, DT.491362, DT.101387053, DT.103551623
NIA Mouse Gene Index U043484
Consensus CDS Project CCDS37229.1
International Mouse Phenotyping Consortium Status Sp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035159 VEGA Gene Model | MGI Sequence Detail 30262 C57BL/6J ±  kb
transcript OTTMUST00000089563 VEGA | MGI Sequence Detail 4081 Not Applicable 
polypeptide OTTMUSP00000048965 VEGA | MGI Sequence Detail 781 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(4) UniProt(6)
Polymorphisms
RFLP(7) : SNPs within 2kb(132 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000000133 transcription factor Sp1
References
(Earliest) J:10955 Dhir R, et al., Structural and functional characterization of the mouse multidrug resistance gene family. Bull Cancer (Paris). 1990;77(11):1125-9
(Latest) J:212420 Kolesnikoff N, et al., Specificity protein 1 (Sp1) maintains basal epithelial expression of the miR-200 family: implications for epithelial-mesenchymal transition. J Biol Chem. 2014 Apr 18;289(16):11194-205
All references(139)
Other
accession IDs
MGD-MRK-14512, MGI:1915735, MGI:2146073, MGI:3034478

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory