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Qk Gene Detail
Summary
  • Symbol
    Qk
  • Name
    quaking, KH domain containing RNA binding
  • Synonyms
    1110003F05Rik, l(17)-1Wis, l17Wis1, QkI
  • Feature Type
    protein coding gene
  • IDs
    MGI:97837
    NCBI Gene: 19317
  • Gene Overview
    MyGene.info: QKI
  • Alliance
    gene page
  • Transcription Start Sites
    29 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:10425400-10538706 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 7.75 cM
  • Mapping Data
    23 experiments
Strain
Comparison
more
  • SNPs within 2kb
    266 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97837
 protein coding gene Chr17:10421530-10538783 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023140
 protein coding gene Chr17:7779518-7907397 (-)
A/J MGP_AJ_G0023108
 protein coding gene Chr17:7700460-7815071 (-)
AKR/J MGP_AKRJ_G0023072
 protein coding gene Chr17:7435173-7552497 (-)
BALB/cJ MGP_BALBcJ_G0023108
 protein coding gene Chr17:7487982-7567784 (-)
C3H/HeJ MGP_C3HHeJ_G0022871
 protein coding gene Chr17:7723634-7846516 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023551
 protein coding gene Chr17:8094337-8213257 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021057
 protein coding gene Chr17:6600656-6709475 (+)
CAST/EiJ MGP_CASTEiJ_G0022385
 protein coding gene Chr17:7737805-7856412 (-)
CBA/J MGP_CBAJ_G0022843
 protein coding gene Chr17:8397874-8528204 (-)
DBA/2J MGP_DBA2J_G0022976
 protein coding gene Chr17:7343790-7457506 (-)
FVB/NJ MGP_FVBNJ_G0022946
 protein coding gene Chr17:7293919-7371788 (-)
LP/J MGP_LPJ_G0023048
 protein coding gene Chr17:7572111-7693688 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022965
 protein coding gene Chr17:8056418-8203017 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023577
 protein coding gene Chr17:7738569-7853335 (-)
PWK/PhJ MGP_PWKPhJ_G0022133
 protein coding gene Chr17:7032699-7145220 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021963
 protein coding gene Chr17:7092775-7208570 (-)
WSB/EiJ MGP_WSBEiJ_G0022442
 protein coding gene Chr17:8045374-8162246 (-)



Homology
more
  • Human Ortholog
    QKI, QKI, KH domain containing RNA binding
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    QKI, QKI, KH domain containing RNA binding
  • Synonyms
    Hqk, hqkI, QK, QK1, QK3
  • Links
    NCBI Gene ID: 9444
    neXtProt AC: NX_Q96PU8
    UniProt: Q96PU8

  • Chr Location
    6q26; chr6:163414486-163578596 (+)  GRCh38.p7
  • Alliance of Genome Resources
    Qk stringent orthology
    1 human;1 mouse;1 rat;3 zebrafish
  • HCOP
    vertebrate homology predictions: QKI
  • Gene Tree
    Qk
Human Diseases
less
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    72 phenotypes from 9 alleles in 15 genetic backgrounds
    7 phenotypes from multigenic genotypes
    3 images
    429 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Knock-out mice die in utero with defects in embryo turning, blood vessel, smooth muscle, cardiac and neural tube development. Homozygotes for a spontaneous allele are viable but show myelin, spermatogenic and behavioral defects, hind leg tremors and seizures. Most ENU-induced mutants die in utero.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1171
  • Tissues
    107
  • cDNA Data
    29
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19317 NCBI Gene Model | MGI Sequence Detail 113307 C57BL/6J ±  kb
    transcript NM_021881 RefSeq | MGI Sequence Detail 6718 C57BL/6  
    polypeptide Q9QYS9 UniProt | EBI | MGI Sequence Detail 341 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 9
      cDNA 30
      Primer pair 4
      Other 2

      Microarray probesets 14
    Other
    Accession IDs
    less
    MGD-MRK-11678, MGD-MRK-11696, MGD-MRK-13738, MGI:1913395, MGI:96711
    References
    more
    • Summaries
      All 505
      Developmental Gene Expression 20
      Diseases 5
      Gene Ontology 14
      Phenotypes 429
    • Earliest
      J:13141 SIDMAN RL, et al., MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM. Science. 1964 Apr 17;144:309-11
    • Latest
      J:316336 Victorino DB, et al., Atypical electrophysiological and behavioral responses to diazepam in a leading mouse model of Down syndrome. Sci Rep. 2021 May 4;11(1):9521
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/12/2022
    MGI 6.17     		The Jackson Laboratory