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Qk Gene Detail
Summary
  • Symbol
    Qk
  • Name
    quaking
  • Synonyms
    1110003F05Rik, l(17)-1Wis, l17Wis1, QkI
  • Feature Type
    protein coding gene
  • IDs
    MGI:97837
    NCBI Gene: 19317
  • Gene Overview
    MyGene.info: QKI
Location & Maps
more
  • Sequence Map
    Chr17:10206471-10319361 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      112891 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    QKI, QKI, KH domain containing, RNA binding
  • Vertebrate Orthologs
    9
  • Human Ortholog
    QKI, QKI, KH domain containing, RNA binding
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Hqk, hqkI, QK, QK1, QK3
  • Links
    NCBI Gene ID: 9444
    neXtProt AC: NX_Q96PU8

  • Chr Location
    6q26; chr6:163414643-163578596 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11059
    1 human;1 mouse;1 rat;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: QKI
  • Gene Tree
    Qk
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    71 phenotypes from 9 alleles in 14 genetic backgrounds
    7 phenotypes from multigenic genotypes
    3 images
    110 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    48
  • Chemically induced (ENU)
    5
  • Gene trapped
    31
  • Not Applicable
    1
  • Radiation induced
    7
  • Spontaneous
    3
  • Targeted
    1
  • Genomic Mutations
    9 involving Qk
  • Incidental Mutations
Knock-out mice die in utero with defects in embryo turning, blood vessel, smooth muscle, cardiac and neural tube development. Homozygotes for a spontaneous allele are viable but show myelin, spermatogenic and behavioral defects, hind leg tremors and seizures. Most ENU-induced mutants die in utero.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000062078 Ensembl Gene Model | MGI Sequence Detail 112891 C57BL/6J ±  kb
transcript ENSMUST00000097414 Ensembl | MGI Sequence Detail 4658 Not Applicable  
polypeptide ENSMUSP00000095025 Ensembl | MGI Sequence Detail 341 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    266 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013564 protein quaking
  • PDB
  • InterPro Domains
    IPR004087 K Homology domain
    IPR004088 K Homology domain, type 1
    IPR032367 Protein quaking, putative nuclear localisation signal
    IPR032377 STAR protein, homodimerisation region
Molecular
Reagents
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  • All nucleic 43
    Genomic 9
    cDNA 28
    Primer pair 4
    Other 2

    Microarray probesets 14
Other
Accession IDs
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MGD-MRK-11678, MGD-MRK-11696, MGD-MRK-13738, MGI:1913395, MGI:96711
References
more
  • Summaries
    All 164
    Developmental Gene Expression 16
    Gene Ontology 12
    Phenotypes 110
  • Earliest
    J:13141 SIDMAN RL, et al., MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM. Science. 1964 Apr 17;144:309-11
  • Latest
    J:218064 Chaverneff F, et al., Dysmyelination with preservation of transverse bands in a long-lived allele of the quaking mouse. J Comp Neurol. 2015 Feb 1;523(2):197-208

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory