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Qk
Gene Detail
 Symbol
Name
ID
Qk
quaking
MGI:97837
Synonyms 1110003F05Rik, l(17)-1Wis, l17Wis1, QkI
Feature Type protein coding gene
Genetic Map
Chromosome 17
7.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)
Sequence Map
Chr17:10206471-10319361 bp, - strand
From NCBI annotation of GRCm38

  112891 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11059  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Human
homologs
Human Homolog QKI, QKI, KH domain containing, RNA binding
NCBI Gene ID 9444
neXtProt AC  NX_Q96PU8
Human Synonyms  Hqk, hqkI, QK, QK1, QK3
Human Chr (Location)  6q26; chr6:163414643-163578596 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Chemically induced (ENU)(5) Gene trapped(31) Spontaneous(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Knock-out mice die in utero with defects in embryo turning, blood vessel, smooth muscle, cardiac and neural tube development. Homozygotes for a spontaneous allele are viable but show myelin, spermatogenic and behavioral defects, hind leg tremors and seizures. Most ENU-induced mutants die in utero.
 
Phenotype Images(2)
Interactions
Qk interacts with 520 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process 3'-UTR-mediated mRNA destabilization, axon ensheathment, ...
Component cytoplasm, nucleus
Function mRNA binding, poly(A) RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (457)    Tissues (83)    Images (26)
Theiler Stages: 13, 18, 20, 21, 22, 23, 28
Assay TypeResults
RNA in situ 409
RT-PCR 48
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(9) cDNA(28) Primer pair(4) Other(2)
Microarray probesets(14)
Other database
links
Ensembl Gene ModelENSMUSG00000044407 (Evidence), ENSMUSG00000062078 (Evidence)
Entrez Gene19317 (Evidence)
PDB4DNN
Consensus CDS ProjectCCDS28387.1, CCDS49947.1
International Mouse Knockout Project StatusQk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19317 NCBI Gene Model | MGI Sequence Detail 112891 C57BL/6J ±  kb
transcript NM_021881 RefSeq | MGI Sequence Detail 6718 C57BL/6 
polypeptide Q9QYS9 UniProt | EBI | MGI Sequence Detail 341 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(12) UniProt(3)
Polymorphisms SNPs within 2kb(264 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004087 K Homology domain
InterPro IPR004088 K Homology domain, type 1
Protein Ontology PR:000013564 protein quaking
Graphical View of Protein Domain Structure
References (Earliest) J:13141 SIDMAN RL, et al., MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM. Science. 1964 Apr 17;144:309-11
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(158)
Other
accession IDs
MGD-MRK-11678, MGD-MRK-11696, MGD-MRK-13738, MGI:1913395, MGI:96711

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory