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Qk Gene Detail
Summary
  • Symbol
    Qk
  • Name
    quaking
  • Synonyms
    1110003F05Rik, l(17)-1Wis, l17Wis1, QkI
  • Feature Type
    protein coding gene
  • IDs
    MGI:97837
    NCBI Gene: 19317
  • Gene Overview
    MyGene.info: QKI
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr17:10206471-10319361 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      112891 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 7.75 cM
  • Mapping Data
    23 experiments
Homology
more
  • Human Ortholog
    QKI, QKI, KH domain containing RNA binding
  • Vertebrate Orthologs
    9
  • Human Ortholog
    QKI, QKI, KH domain containing RNA binding
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Hqk, hqkI, QK, QK1, QK3
  • Links
    NCBI Gene ID: 9444
    neXtProt AC: NX_Q96PU8
    UniProt: Q96PU8

  • Chr Location
    6q26; chr6:163414486-163578596 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 11059
    1 human;1 mouse;1 rat;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: QKI
  • Gene Tree
    Qk
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    71 phenotypes from 9 alleles in 14 genetic backgrounds
    7 phenotypes from multigenic genotypes
    3 images
    115 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Knock-out mice die in utero with defects in embryo turning, blood vessel, smooth muscle, cardiac and neural tube development. Homozygotes for a spontaneous allele are viable but show myelin, spermatogenic and behavioral defects, hind leg tremors and seizures. Most ENU-induced mutants die in utero.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    29
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    457
  • Tissues
    89
  • cDNA Data
    27
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19317 NCBI Gene Model | MGI Sequence Detail 112891 C57BL/6J ±  kb
    transcript NM_021881 RefSeq | MGI Sequence Detail 6718 C57BL/6  
    polypeptide Q9QYS9 UniProt | EBI | MGI Sequence Detail 341 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      266 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 9
      cDNA 28
      Primer pair 4
      Other 2

      Microarray probesets 14
    Other
    Accession IDs
    less
    MGD-MRK-11678, MGD-MRK-11696, MGD-MRK-13738, MGI:1913395, MGI:96711
    References
    more
    • Summaries
      All 186
      Developmental Gene Expression 17
      Gene Ontology 12
      Phenotypes 115
    • Earliest
      J:13141 SIDMAN RL, et al., MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM. Science. 1964 Apr 17;144:309-11
    • Latest
      J:260936 Shingu T, et al., Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation. Nat Genet. 2017 Jan;49(1):75-86
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/05/2018
    MGI 6.12     		The Jackson Laboratory