Qk
Gene Detail

Symbol Name ID

Qk quaking MGI:97837

Synonyms

1110003F05Rik, l(17)-1Wis, l17Wis1, QkI

Feature Type

protein coding gene

Genetic Map

Chromosome 17

7.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)

Sequence Map

Chr17:10206471-10319361 bp, - strand From NCBI annotation of GRCm38   112891 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11059  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Human homologs

Human Homolog		QKI, QKI, KH domain containing, RNA binding
NCBI Gene ID		9444
neXtProt AC		NX_Q96PU8
Human Synonyms		Hqk, hqkI, QK, QK1, QK3
Human Chr (Location)		6q26; chr6:163414643-163578596 (+)  GRCh38

Alleles and phenotypes

All alleles(39) : Targeted(1) Gene trapped(31) Spontaneous(2) Chemically induced(5)
 

Knock-out mice die in utero with defects in embryo turning, blood vessel, smooth muscle, cardiac and neural tube development. Homozygotes for a spontaneous allele are viable but show myelin, spermatogenic and behavioral defects, hind leg tremors and seizures. Most ENU-induced mutants die in utero.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	axon ensheathment, cell differentiation, ...
Component	cytoplasm, nucleus
Function	poly(A) RNA binding, RNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)

Data Summary: Results (457)    Tissues (83)    Images (26)
Theiler Stages: 13, 18, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	409
RT-PCR	48

cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(43) Genomic(9) cDNA(28) Primer pair(4) Other(2)
Microarray probesets(14)

Other database links

Ensembl Gene Model	ENSMUSG00000044407 (Evidence), ENSMUSG00000062078 (Evidence)
Entrez Gene	19317 (Evidence)
PDB	4DNN
Consensus CDS Project	CCDS28387.1, CCDS49947.1
International Mouse Knockout Project Status	Qk

Sequences

Length	Strain/Species
genomic	19317	NCBI Gene Model | MGI Sequence Detail	112891	C57BL/6J
transcript	NM_021881	RefSeq | MGI Sequence Detail	6718	C57BL/6
polypeptide	Q9QYS9	UniProt | EBI | MGI Sequence Detail	341	Not Applicable

All sequences(67) RefSeq(12) UniProt(3)

Polymorphisms

SNPs within 2kb(264 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR004087	K Homology domain
InterPro	IPR004088	K Homology domain, type 1
Protein Ontology	PR:000013564	protein quaking

Graphical View of Protein Domain Structure

References

(Earliest) J:13141 SIDMAN RL, et al., MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM. Science. 1964 Apr 17;144:309-11
(Latest) J:199892 Rhee S, et al., Visceral endoderm expression of Yin-Yang1 (YY1) is required for VEGFA maintenance and yolk sac development. PLoS One. 2013;8(3):e58828
All references(157)

Other accession IDs

MGD-MRK-11678, MGD-MRK-11696, MGD-MRK-13738, MGI:1913395, MGI:96711