Qk
Gene Detail

Symbol

Name
ID

Qk
quaking
MGI:97837

Synonyms

1110003F05Rik, l(17)-1Wis, l17Wis1, QkI

Feature Type

protein coding gene

Genetic Map

Chromosome 17
7.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)

Sequence Map

Chr17:10206471-10319361 bp, - strand From Ensembl annotation of GRCm38   112891 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:11059  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Qk

Human
homologs

Human Homolog		QKI, QKI, KH domain containing, RNA binding
NCBI Gene ID		9444
neXtProt AC		NX_Q96PU8
Human Synonyms		Hqk, hqkI, QK, QK1, QK3
Human Chr (Location)		6q26; chr6:163414643-163578596 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(39) : Chemically induced (ENU)(5) Gene trapped(31) Spontaneous(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 

Knock-out mice die in utero with defects in embryo turning, blood vessel, smooth muscle, cardiac and neural tube development. Homozygotes for a spontaneous allele are viable but show myelin, spermatogenic and behavioral defects, hind leg tremors and seizures. Most ENU-induced mutants die in utero.

 
Phenotype Images(2)

Interactions

Qk interacts with 520 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (23 annotations)

Process	3'-UTR-mediated mRNA destabilization, axon ensheathment, ...
Component	cytoplasm, nucleus
Function	mRNA binding, nucleic acid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (15 records)

Data Summary: Results (457)    Tissues (83)    Images (26)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	409
RT-PCR	44

cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(43) Genomic(9) cDNA(28) Primer pair(4) Other(2)
Microarray probesets(14)

Other database
links

Ensembl Gene Model	ENSMUSG00000062078 (Evidence)
Entrez Gene	19317 (Evidence)
PDB	4DNN
Consensus CDS Project	CCDS28387.1, CCDS49947.1
International Mouse Knockout Project Status	Qk

Sequences

Length	Strain/Species
genomic	ENSMUSG00000062078	Ensembl Gene Model | MGI Sequence Detail	112891	C57BL/6J
transcript	ENSMUST00000097414	Ensembl | MGI Sequence Detail	4658	Not Applicable
polypeptide	ENSMUSP00000095025	Ensembl | MGI Sequence Detail	341	Not Applicable

All sequences(66) RefSeq(12) UniProt(5)

Polymorphisms

SNPs within 2kb(264 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR004087	K Homology domain
InterPro	IPR004088	K Homology domain, type 1
Protein Ontology	PR:000013564	protein quaking

References

(Earliest) J:13141 SIDMAN RL, et al., MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM. Science. 1964 Apr 17;144:309-11
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(159)

Other
accession IDs

MGD-MRK-11678, MGD-MRK-11696, MGD-MRK-13738, MGI:1913395, MGI:96711