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Qk
Gene Detail
Symbol

Name
ID
Qk
quaking
MGI:97837
Synonyms
1110003F05Rik, l(17)-1Wis, l17Wis1, QkI
Feature Type
protein coding gene
Genetic Map
Chromosome 17
7.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(22)
Sequence Map
Chr17:10206471-10319361 bp, - strand
From Ensembl annotation of GRCm38

  112891 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11059  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: QKI
Gene Tree: Qk

Human
homologs
QKI, QKI, KH domain containing, RNA binding
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9444
neXtProt AC: NX_Q96PU8

Human Synonyms: Hqk, hqkI, QK, QK1, QK3

Human Chr (Location): 6q26; chr6:163414643-163578596 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(40) : Chemically induced (ENU)(5) Gene trapped(31) Spontaneous(3) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Knock-out mice die in utero with defects in embryo turning, blood vessel, smooth muscle, cardiac and neural tube development. Homozygotes for a spontaneous allele are viable but show myelin, spermatogenic and behavioral defects, hind leg tremors and seizures. Most ENU-induced mutants die in utero.
 
Phenotype Images(3)
Interactions
Qk interacts with 519 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process 3'-UTR-mediated mRNA destabilization, axon ensheathment, ...
Component cytoplasm, nucleus
Function mRNA binding, nucleic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (457)    Tissues (89)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 409
RT-PCR 48
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase qki ; ZFIN qkia    NEW 
Molecular
reagents
All nucleic(43) Genomic(9) cDNA(28) Primer pair(4) Other(2)
Microarray probesets(14)
Other database
links
Ensembl Gene Model ENSMUSG00000062078 (Evidence)
Entrez Gene 19317 (Evidence)
PDB 4DNN
Consensus CDS Project CCDS28387.1, CCDS49947.1
International Mouse Phenotyping Consortium Status Qk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000062078 Ensembl Gene Model | MGI Sequence Detail 112891 C57BL/6J ±  kb
transcript ENSMUST00000097414 Ensembl | MGI Sequence Detail 4658 Not Applicable 
polypeptide ENSMUSP00000095025 Ensembl | MGI Sequence Detail 341 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(12) UniProt(3)
Polymorphisms
SNPs within 2kb(264 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004087 K Homology domain
InterPro IPR004088 K Homology domain, type 1
Protein Ontology PR:000013564 protein quaking
References
(Earliest) J:13141 SIDMAN RL, et al., MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM. Science. 1964 Apr 17;144:309-11
(Latest) J:218064 Chaverneff F, et al., Dysmyelination with preservation of transverse bands in a long-lived allele of the quaking mouse. J Comp Neurol. 2015 Feb 1;523(2):197-208
All references(163)
Other
accession IDs
MGD-MRK-11678, MGD-MRK-11696, MGD-MRK-13738, MGI:1913395, MGI:96711

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory