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Prkcb Gene Detail
Summary
  • Symbol
    Prkcb
  • Name
    protein kinase C, beta
  • Synonyms
    A130082F03Rik, Pkcb, PKC-Beta, Prkcb1, Prkcb2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97596
    NCBI Gene: 18751
  • Gene Overview
    MyGene.info: PRKCB
Location & Maps
more
  • Sequence Map
    Chr7:122288751-122634402 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      345652 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 65.75 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    PRKCB, protein kinase C beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRKCB, protein kinase C beta
    Orthology source: HomoloGene
  • Synonyms
    PKCB, PKC-beta, PRKCB1, PRKCB2
  • Links
    NCBI Gene ID: 5579
    neXtProt AC: NX_P05771

  • Chr Location
    16p11.2; chr16:23835979-24220611 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 5 alleles in 10 genetic backgrounds
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (ENU)
    4
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for a null allele exhibit impaired humoral immune responses, altered proliferative responses of B cells to various stimuli, abnormal vascular wound healing, and deficits in contextual and cued fear conditioning. ENU-induced mutations leadto impaired T cell-independent IgM responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016521 VEGA Gene Model | MGI Sequence Detail 345652 C57BL/6J ±  kb
transcript OTTMUST00000039929 VEGA | MGI Sequence Detail 3328 Not Applicable  
polypeptide OTTMUSP00000065168 VEGA | MGI Sequence Detail 673 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2521 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 1
    cDNA 13
    Primer pair 1
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-13328, MGI:2442598
References
more
  • Summaries
    All 144
    Developmental Gene Expression 23
    Gene Ontology 20
    Phenotypes 49
  • Earliest
    J:10128 Wada H, et al., Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. Biochem Biophys Res Commun. 1989 Nov 30;165(1):533-8
  • Latest
    J:228459 Schiffer M, et al., Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Nat Med. 2015 Jun;21(6):601-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory