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Prkcb
Gene Detail
 Symbol
Name
ID
Prkcb
protein kinase C, beta
MGI:97596
Synonyms A130082F03Rik, Pkcb, PKC-Beta, Prkcb1, Prkcb2
Feature Type protein coding gene
Genetic Map
Chromosome 7
65.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr7:122288751-122634402 bp, + strand
From VEGA annotation of GRCm38

  345652 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56424  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: protein kinase C, alpha/beta/gamma types
Gene Tree: Prkcb

Human
homologs
Human Homolog PRKCB, protein kinase C, beta
NCBI Gene ID 5579
neXtProt AC  NX_P05771
Human Synonyms  PKCB, PKC-beta, PRKCB1, PRKCB2
Human Chr (Location)  16p11.2; chr16:23835979-24220611 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit impaired humoral immune responses, altered proliferative responses of B cells to various stimuli, abnormal vascular wound healing, and deficits in contextual and cued fear conditioning. ENU-induced mutations lead to impaired T cell-independent IgM responses.
 
Interactions
Prkcb interacts with 230 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process apoptotic process, B cell activation, ...
Component brush border membrane, centrosome, ...
Function androgen receptor binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (124)    Tissues (66)    Images (22)
Theiler Stages: 2, 3, 5, 19, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 77
Western blot 32
RT-PCR 11
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(13) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000016521 (Evidence)
Ensembl Gene ModelENSMUSG00000052889 (Evidence)
Entrez Gene18751 (Evidence)
DFCITC1579462, TC1582051, TC1625960, TC1628120
DoTSDT.532374, DT.97356798
NIA Mouse Gene IndexU008730
EC2.7.11.13
Consensus CDS ProjectCCDS21815.1
International Mouse Knockout Project StatusPrkcb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016521 VEGA Gene Model | MGI Sequence Detail 345652 C57BL/6J ±  kb
transcript OTTMUST00000039929 VEGA | MGI Sequence Detail 3328 Not Applicable 
polypeptide OTTMUSP00000065168 VEGA | MGI Sequence Detail 673 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(2)
Polymorphisms RFLP(3) : SNPs within 2kb(2535 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR014375 Protein kinase C, alpha/beta/gamma types
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000003059 protein kinase C beta type
References (Earliest) J:10128 Wada H, et al., Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. Biochem Biophys Res Commun. 1989 Nov 30;165(1):533-8
(Latest) J:210179 Zhang H, et al., STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense. Blood. 2014 Apr 3;123(14):2238-49
All references(139)
Other
accession IDs
MGD-MRK-13328, MGI:2442598

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory