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Nos1
Gene Detail
Symbol

Name
ID
Nos1
nitric oxide synthase 1, neuronal
MGI:97360
Synonyms
2310005C01Rik, bNOS, nNOS, NO, Nos-1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
57.29 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr5:117781032-117958840 bp, + strand
From VEGA annotation of GRCm38

  177809 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37327  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NOS1
Protein SuperFamily: nitric-oxide synthase, inducible
Gene Tree: Nos1

Human
homologs
NOS1, nitric oxide synthase 1 (neuronal)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4842
neXtProt AC: NX_P29475

Human Synonyms: bNOS, IHPS1, NC-NOS, nNOS, N-NOS, NOS

Human Chr (Location): 12q24.22; chr12:117208142-117361802 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(6) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous hypomorphic mice exhibit enlarged stomachs, abnormal pyloric and lower esophageal sphincters, age-related cardiac hypertrophy, altered alcohol consumption and responses, decreased ovulation and reduced REM sleep. Homozygous null mice display increased neurogenesis in the adult brain.
 
Human Diseases Modeled in Mice Using Nos1 (2)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Nos1 interacts with 384 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (101 annotations)
Process arginine catabolic process, behavioral response to cocaine, ...
Component azurophil granule, caveola, ...
Function ATPase binding, cadmium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (90 records)
Data Summary: Results (699)    Tissues (348)    Images (109)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 180
RNA in situ 413
Western blot 6
RT-PCR 100
cDNA source data(9)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase nos1 ; ZFIN nos1    NEW 
Molecular
reagents
All nucleic(15) Genomic(2) cDNA(9) Primer pair(3) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000016286 (Evidence)
Ensembl Gene Model ENSMUSG00000029361 (Evidence)
Entrez Gene 18125 (Evidence)
DFCI TC1602786, TC1656327
DoTS DT.103579166, DT.483561, DT.60101006, DT.97397113
EC 1.14.13.39
PDB 2O60
Consensus CDS Project CCDS19606.1
International Mouse Phenotyping Consortium Status Nos1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016286 VEGA Gene Model | MGI Sequence Detail 177809 C57BL/6J ±  kb
transcript OTTMUST00000039109 VEGA | MGI Sequence Detail 4591 Not Applicable 
polypeptide OTTMUSP00000017466 VEGA | MGI Sequence Detail 1463 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(14) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(1239 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003097 FAD-binding, type 1
InterPro IPR017927 Ferredoxin reductase-type FAD-binding domain
InterPro IPR001094 Flavodoxin
InterPro IPR008254 Flavodoxin/nitric oxide synthase
InterPro IPR029039 Flavoprotein-like
InterPro IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
InterPro IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain-3
InterPro IPR012144 Nitric-oxide synthase, eukaryote
InterPro IPR004030 Nitric oxide synthase, N-terminal
InterPro IPR001433 Oxidoreductase FAD/NAD(P)-binding
InterPro IPR001478 PDZ domain
InterPro IPR017938 Riboflavin synthase-like beta-barrel
Protein Ontology PR:000011326 nitric oxide synthase, brain
References
(Earliest) J:2324 Lyons CR, et al., Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J Biol Chem. 1992 Mar 25;267(9):6370-4
(Latest) J:222718 Adams KL, et al., Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells. Nat Commun. 2015;6:6778
All references(460)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-12909, MGD-MRK-12912, MGI:1923980

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory