Nos1
Gene Detail

Symbol Name ID

Nos1 nitric oxide synthase 1, neuronal MGI:97360

Synonyms

2310005C01Rik, bNOS, nNOS, NO, Nos-1

Feature Type

protein coding gene

Genetic Map

Chromosome 5

57.29 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr5:117781032-117958840 bp, + strand From VEGA annotation of GRCm38   177809 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37327  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: nitric-oxide synthase, inducible
Gene Tree: Nos1

Human homologs

Human Homolog		NOS1, nitric oxide synthase 1 (neuronal)
NCBI Gene ID		4842
neXtProt AC		NX_P29475
Human Synonyms		bNOS, IHPS1, NC-NOS, nNOS, N-NOS, NOS
Human Chr (Location)		12q24.2-q24.31; chr12:117645947-117799607 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(12) : Targeted(6) Gene trapped(6)
 

Homozygous hypomorphic mice exhibit enlarged stomachs, abnormal pyloric and lower esophageal sphincters, age-related cardiac hypertrophy, altered alcohol consumption and responses, decreased ovulation and reduced REM sleep. Homozygous null mice display increased neurogenesis in the adult brain.

 
Human Diseases Modeled Using Mouse Nos1 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (74 annotations)

Process	arginine catabolic process, cellular response to growth factor stimulus, ...
Component	azurophil granule, cell projection, ...
Function	cadmium ion binding, calmodulin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (76 records)
Data Summary: Results (496)    Tissues (217)    Images (76)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	385
Western blot	6
RT-PCR	100

cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(15) Genomic(2) cDNA(9) Primer pair(3) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000016286 (Evidence)
Ensembl Gene Model	ENSMUSG00000029361 (Evidence)
Entrez Gene	18125 (Evidence)
DFCI	TC1602786, TC1656327
DoTS	DT.103579166, DT.483561, DT.60101006, DT.97397113
NIA Mouse Gene Index	U067644
EC	1.14.13.39
PDB	2O60
Consensus CDS Project	CCDS19606.1
International Mouse Knockout Project Status	Nos1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016286	VEGA Gene Model | MGI Sequence Detail	177809	C57BL/6J
transcript	OTTMUST00000039109	VEGA | MGI Sequence Detail	9522	Not Applicable
polypeptide	OTTMUSP00000017466	VEGA | MGI Sequence Detail	1463	Not Applicable

All sequences(42) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(368 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003097	FAD-binding, type 1
InterPro	IPR017927	Ferredoxin reductase-type FAD-binding domain
InterPro	IPR001094	Flavodoxin
InterPro	IPR008254	Flavodoxin/nitric oxide synthase
InterPro	IPR001709	Flavoprotein pyridine nucleotide cytochrome reductase
InterPro	IPR023173	NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain-3
InterPro	IPR026009	Nitric-oxide synthase
InterPro	IPR012144	Nitric-oxide synthase, metazoa
InterPro	IPR004030	Nitric oxide synthase, oxygenase domain
InterPro	IPR001433	Oxidoreductase FAD/NAD(P)-binding
InterPro	IPR001478	PDZ domain
InterPro	IPR017938	Riboflavin synthase-like beta-barrel
Protein Ontology	PR:000011326	nitric oxide synthase, brain

References

(Earliest) J:2324 Lyons CR, et al., Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J Biol Chem. 1992 Mar 25;267(9):6370-4
(Latest) J:194321 Nott A, et al., S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3113-8
All references(419)

Other accession IDs

MGD-MRK-12909, MGD-MRK-12912, MGI:1923980