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Nos1
Gene Detail
Symbol

Name
ID
Nos1
nitric oxide synthase 1, neuronal
MGI:97360
Synonyms
2310005C01Rik, bNOS, nNOS, NO, Nos-1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
57.29 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr5:117781032-117958840 bp, + strand
From VEGA annotation of GRCm38

  177809 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37327  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: nitric-oxide synthase, inducible
Gene Tree: Nos1

Human
homologs
Human Homolog NOS1, nitric oxide synthase 1 (neuronal)
NCBI Gene ID 4842
neXtProt AC  NX_P29475
Human Synonyms  bNOS, IHPS1, NC-NOS, nNOS, N-NOS, NOS
Human Chr (Location)  12q24.22; chr12:117208142-117441825 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(6) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous hypomorphic mice exhibit enlarged stomachs, abnormal pyloric and lower esophageal sphincters, age-related cardiac hypertrophy, altered alcohol consumption and responses, decreased ovulation and reduced REM sleep. Homozygous null mice display increased neurogenesis in the adult brain.
 
Human Diseases Modeled Using Mouse Nos1 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Nos1 interacts with 385 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (94 annotations)
Process arginine catabolic process, behavioral response to cocaine, ...
Component azurophil granule, cell projection, ...
Function ATPase binding, cadmium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (86 records)
Data Summary: Results (573)    Tissues (256)    Images (109)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 54
RNA in situ 413
Western blot 6
RT-PCR 100
cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(2) cDNA(9) Primer pair(3) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000016286 (Evidence)
Ensembl Gene ModelENSMUSG00000029361 (Evidence)
Entrez Gene18125 (Evidence)
DFCITC1602786, TC1656327
DoTSDT.103579166, DT.483561, DT.60101006, DT.97397113
EC1.14.13.39
PDB2O60
Consensus CDS ProjectCCDS19606.1
International Mouse Knockout Project StatusNos1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016286 VEGA Gene Model | MGI Sequence Detail 177809 C57BL/6J ±  kb
transcript OTTMUST00000039109 VEGA | MGI Sequence Detail 4591 Not Applicable 
polypeptide OTTMUSP00000017466 VEGA | MGI Sequence Detail 1463 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(16) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(1239 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003097 FAD-binding, type 1
InterPro IPR017927 Ferredoxin reductase-type FAD-binding domain
InterPro IPR001094 Flavodoxin
InterPro IPR008254 Flavodoxin/nitric oxide synthase
InterPro IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
InterPro IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain-3
InterPro IPR012144 Nitric-oxide synthase, metazoa
InterPro IPR004030 Nitric oxide synthase, oxygenase domain
InterPro IPR001433 Oxidoreductase FAD/NAD(P)-binding
InterPro IPR001478 PDZ domain
InterPro IPR017938 Riboflavin synthase-like beta-barrel
Protein Ontology PR:000011326 nitric oxide synthase, brain
References
(Earliest) J:2324 Lyons CR, et al., Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J Biol Chem. 1992 Mar 25;267(9):6370-4
(Latest) J:212751 Bellefontaine N, et al., Leptin-dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction. J Clin Invest. 2014 Jun 2;124(6):2550-9
All references(449)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-12909, MGD-MRK-12912, MGI:1923980

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory