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Marcksl1
Gene Detail
 Symbol
Name
ID
Marcksl1
MARCKS-like 1
MGI:97143
Synonyms D4Bc1, F52, MacMARCKS, Macs2, Macs-2, Macs3, Macs-3, Mlp, Mrp
Feature Type protein coding gene
Genetic Map
Chromosome 4
63.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:129513581-129515985 bp, + strand
From VEGA annotation of GRCm38

  2405 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40748  Vertebrate Homology Class
1 human; 1 mouse; 3 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Marcksl1

Human
homologs
Human Homolog MARCKSL1, MARCKS-like 1
NCBI Gene ID 65108
neXtProt AC  NX_P49006
Human Synonyms  F52, MACMARCKS, MLP, MLP1, MRP
Human Chr (Location)  1p35.1; chr1:32333829-32336239 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(26) Targeted(4)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit neural tube defects resulting in anencephaly, spina bifida, abnormal brain development, tail malformations, and neonatal lethality. A small percentage of heterozygotes also show neural tube defects.
 
Interactions
Marcksl1 interacts with 237 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process positive regulation of cell proliferation
Component cytoplasm, extracellular vesicular exosome, ...
Function actin binding, calmodulin binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (149)    Tissues (135)    Images (34)
Theiler Stages: 19, 20, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 139
Northern blot 10
cDNA source data(255)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(263) Genomic(2) cDNA(259) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000009665 (Evidence)
Ensembl Gene ModelENSMUSG00000047945 (Evidence)
Entrez Gene17357 (Evidence)
UniGene424974
DFCITC1573228, TC1723755, TC1752907
DoTSDT.110817339, DT.536516, DT.94159408, DT.97390047, DT.97390052
NIA Mouse Gene IndexU004869
Consensus CDS ProjectCCDS18695.1
International Mouse Knockout Project StatusMarcksl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009665 VEGA Gene Model | MGI Sequence Detail 2405 C57BL/6J ±  kb
transcript OTTMUST00000022300 VEGA | MGI Sequence Detail 1605 Not Applicable 
polypeptide OTTMUSP00000010174 VEGA | MGI Sequence Detail 200 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(1)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002101 Myristoylated alanine-rich C-kinase substrate MARCKS
Protein Ontology PR:000010185 MARCKS-related protein
References (Earliest) J:1361 Blackshear PJ, et al., Characteristics of the F52 protein, a MARCKS homologue. J Biol Chem. 1992 Jul 5;267(19):13540-6
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(53)
Other
accession IDs
MGD-MRK-12096, MGD-MRK-12097, MGD-MRK-12098, MGD-MRK-12099, MGD-MRK-12538, MGI:2140563, MGI:2146106, MGI:2146223

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory