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Marcksl1
Gene Detail
Symbol

Name
ID
Marcksl1
MARCKS-like 1
MGI:97143
Synonyms
D4Bc1, F52, MacMARCKS, Macs2, Macs-2, Macs3, Macs-3, Mlp, Mrp
Feature Type
protein coding gene
Genetic Map
Chromosome 4
63.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:129513581-129515985 bp, + strand
From VEGA annotation of GRCm38

  2405 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40748  Vertebrate Homology Class
1 human; 1 mouse; 3 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: MARCKSL1
Gene Tree: Marcksl1

Human
homologs
MARCKSL1, MARCKS-like 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 65108
neXtProt AC: NX_P49006

Human Synonyms: F52, MACMARCKS, MLP, MLP1, MRP

Human Chr (Location): 1p35.1; chr1:32333829-32336239 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(26) Targeted(5)
Genomic Mutations involving Marcksl1 (1)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit neural tube defects resulting in anencephaly, spina bifida, abnormal brain development, tail malformations, and neonatal lethality. A small percentage of heterozygotes also show neural tube defects.
 
Interactions
Marcksl1 interacts with 237 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process positive regulation of cell proliferation
Component cytoplasm, extracellular exosome, ...
Function actin binding, calmodulin binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (149)    Tissues (136)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 139
Northern blot 10
cDNA source data(255)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase marcksl1 ; ZFIN marcksl1a    NEW 
Molecular
reagents
All nucleic(263) Genomic(2) cDNA(259) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000009665 (Evidence)
Ensembl Gene Model ENSMUSG00000047945 (Evidence)
Entrez Gene 17357 (Evidence)
UniGene 424974
DFCI TC1752907, TC1723755, TC1573228
DoTS DT.97390047, DT.97390052, DT.94159408, DT.536516, DT.110817339
NIA Mouse Gene Index U004869
Consensus CDS Project CCDS18695.1
International Mouse Phenotyping Consortium Status Marcksl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009665 VEGA Gene Model | MGI Sequence Detail 2405 C57BL/6J ±  kb
transcript OTTMUST00000022300 VEGA | MGI Sequence Detail 1605 Not Applicable 
polypeptide OTTMUSP00000010174 VEGA | MGI Sequence Detail 200 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(1)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002101 Myristoylated alanine-rich C-kinase substrate MARCKS
Protein Ontology PR:000010185 MARCKS-related protein
References
(Earliest) J:1361 Blackshear PJ, et al., Characteristics of the F52 protein, a MARCKS homologue. J Biol Chem. 1992 Jul 5;267(19):13540-6
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(52)
Other
accession IDs
MGD-MRK-12096, MGD-MRK-12097, MGD-MRK-12098, MGD-MRK-12099, MGD-MRK-12538, MGI:2140563, MGI:2146106, MGI:2146223

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory