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Impdh1
Gene Detail
Symbol

Name
ID
Impdh1
inosine 5'-phosphate dehydrogenase 1
MGI:96567
Synonyms
B930086D20Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 6
12.36 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:29200434-29216364 bp, - strand
From VEGA annotation of GRCm38

  15931 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68096  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: inosine-5'-monophosphate dehydrogenase
Gene Tree: Impdh1

Human
homologs
Human Homolog IMPDH1, IMP (inosine 5'-monophosphate) dehydrogenase 1
NCBI Gene ID 3614
neXtProt AC  NX_P20839
Human Synonyms  IMPD, IMPD1, LCA11, RP10, sWSS2608
Human Chr (Location)  7q31.3-q32; chr7:128392277-128409988 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human IMPDH1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mic homozygous for disruptions of this gene display abnormalities in T cell proliferation but are otherwise phenotypically normal.
 
Interactions
Impdh1 interacts with 190 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process GMP biosynthetic process, lymphocyte proliferation, ...
Component cell junction, cytoplasm, ...
Function catalytic activity, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (2)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033782 (Evidence)
Ensembl Gene ModelENSMUSG00000003500 (Evidence)
Entrez Gene23917 (Evidence)
DFCITC1578623, TC1682799
DoTSDT.101262509, DT.101350368, DT.40181312
NIA Mouse Gene IndexU027110, U107643
EC1.1.1.205
Consensus CDS ProjectCCDS39449.1
International Mouse Knockout Project StatusImpdh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033782 VEGA Gene Model | MGI Sequence Detail 15931 C57BL/6J ±  kb
transcript OTTMUST00000085113 VEGA | MGI Sequence Detail 2471 Not Applicable 
polypeptide OTTMUSP00000045944 VEGA | MGI Sequence Detail 568 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(16) UniProt(11)
Polymorphisms
SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR000644 Cystathionine beta-synthase, core
InterPro IPR001093 IMP dehydrogenase/GMP reductase
InterPro IPR015875 IMP dehydrogenase / GMP reductase, conserved site
InterPro IPR005990 Inosine-5'-monophosphate dehydrogenase
Protein Ontology PR:000009021 inosine-5'-monophosphate dehydrogenase 1
References
(Earliest) J:43126 Dayton JS, et al., Type I inosine monophosphate dehydrogenase: evidence for a single functional gene in mammalian species. Biochem Biophys Res Commun. 1993 Sep 15;195(2):897-901
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)
Other
accession IDs
MGD-MRK-11401, MGI:2444863

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory