Impdh1
Gene Detail

Symbol Name ID

Impdh1 inosine 5'-phosphate dehydrogenase 1 MGI:96567

Synonyms

B930086D20Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 6

12.36 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:29200434-29216364 bp, - strand From VEGA annotation of GRCm38   15931 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68096  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: inosine-5'-monophosphate dehydrogenase
Gene Tree: Impdh1

Human homologs

Human Homolog		IMPDH1, IMP (inosine 5'-monophosphate) dehydrogenase 1
NCBI Gene ID		3614
neXtProt AC		NX_P20839
Human Synonyms		IMPD, IMPD1, LCA11, RP10, sWSS2608
Human Chr (Location)		7q31.3-q32; chr7:128032331-128050036 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human IMPDH1

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mic homozygous for disruptions of this gene display abnormalities in T cell proliferation but are otherwise phenotypically normal.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	GMP biosynthetic process, lymphocyte proliferation, ...
Component	cytoplasm, nucleus
Function	catalytic activity, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (2)    Images (8)
Theiler Stages: 28

Assay Type	Results
RNA in situ	4

cDNA source data(58)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(59) cDNA(59)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000033782 (Evidence)
Ensembl Gene Model	ENSMUSG00000003500 (Evidence)
Entrez Gene	23917 (Evidence)
UniGene	260707
DFCI	TC1578623
DoTS	DT.101262509, DT.40181312
NIA Mouse Gene Index	U027110
EC	1.1.1.205
Consensus CDS Project	CCDS39449.1
International Mouse Knockout Project Status	Impdh1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033782	VEGA Gene Model | MGI Sequence Detail	15931	C57BL/6J
transcript	OTTMUST00000085113	VEGA | MGI Sequence Detail	2471	Not Applicable
polypeptide	OTTMUSP00000045944	VEGA | MGI Sequence Detail	568	Not Applicable

All sequences(65) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(45 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013785	Aldolase-type TIM barrel
InterPro	IPR000644	Cystathionine beta-synthase, core
InterPro	IPR001093	IMP dehydrogenase/GMP reductase
InterPro	IPR015875	IMP dehydrogenase / GMP reductase, conserved site
InterPro	IPR005990	Inosine-5'-monophosphate dehydrogenase
Protein Ontology	PR:000009021	inosine-5'-monophosphate dehydrogenase 1

References

(Earliest) J:43126 Dayton JS, et al., Type I inosine monophosphate dehydrogenase: evidence for a single functional gene in mammalian species. Biochem Biophys Res Commun. 1993 Sep 15;195(2):897-901
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)

Other accession IDs

MGD-MRK-11401, MGI:2444863