Igkv15-103 MGI Mouse Gene Detail - MGI:96513 - immunoglobulin kappa chain variable 15-103

Symbol

Igkv15-103
Name

immunoglobulin kappa chain variable 15-103

Feature Type

gene segment
IDs

MGI:96513
NCBI Gene: 692169
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr6:68414452-68414909 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 31.18 cM
Mapping Data

2 experiments

SNPs within 2kb

35 from dbSNP Build 142
Strain Annotations

17
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96513	gene segment	Chr6:68414424-68414909 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0000126	gene segment	Chr6:68650624-68651109 (+)
A/J	MGP_AJ_G0000117	gene segment	Chr6:65735372-65735857 (+)
AKR/J	MGP_AKRJ_G0000123	gene segment	Chr6:67691727-67692212 (+)
BALB/cJ	MGP_BALBcJ_G0000112	gene segment	Chr6:66019641-66020126 (+)
C3H/HeJ	MGP_C3HHeJ_G0000139	gene segment	Chr6:116481662-116482147 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0000165	gene segment	Chr6:70308986-70309471 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0000123	gene segment	Chr6:68042421-68042906 (+)
CBA/J	MGP_CBAJ_G0000117	gene segment	Chr6:73085578-73086063 (+)
DBA/2J	MGP_DBA2J_G0000112	gene segment	Chr6:65334429-65334914 (+)
FVB/NJ	MGP_FVBNJ_G0000112	gene segment	Chr6:64787430-64787915 (+)
LP/J	MGP_LPJ_G0000129	gene segment	Chr6:68468709-68469194 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0000124	gene segment	Chr6:76830593-76831078 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0000149	gene segment	Chr6:67760031-67760516 (+)
PWK/PhJ	MGP_PWKPhJ_G0000105	gene segment	Chr6:64287107-64287572 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0000082	gene segment	Chr6:67151494-67151979 (+)
WSB/EiJ	MGP_WSBEiJ_G0000122	gene segment	Chr6:68082192-68082677 (+)

Human Ortholog

IGKC, immunoglobulin kappa constant

Vertebrate Orthologs

12

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IGKC, immunoglobulin kappa constant
Synonyms

HCAK1, IGKCD, Km
Links

HGNC:5716

NCBI Gene ID: 3514

UniProt: P01834
Chr Location

2p11.2; chr2:88857161-88857683 (-) GRCh38

Human Ortholog

IGKV1-12, immunoglobulin kappa variable 1-12
Synonyms

IGKV112, L19
Links

HGNC:5730

NCBI Gene ID: 28940

UniProt: A0A0C4DH73
Chr Location

2p11.2; chr2:89040224-89040745 (-) GRCh38

Human Ortholog

IGKV1-16, immunoglobulin kappa variable 1-16
Synonyms

IGKV116, L1
Links

HGNC:5732

NCBI Gene ID: 28938

UniProt: P04430
Chr Location

2p11.2; chr2:89099859-89100361 (-) GRCh38

Human Ortholog

IGKV1-27, immunoglobulin kappa variable 1-27
Synonyms

A20, IGKV127
Links

HGNC:5735

NCBI Gene ID: 28935

UniProt: A0A075B6S5
Chr Location

2p11.2; chr2:89213423-89213928 (-) GRCh38

Human Ortholog

IGKV1-33, immunoglobulin kappa variable 1-33
Synonyms

IGKV133, O18
Links

HGNC:5737

NCBI Gene ID: 28933
Chr Location

2p11.2; chr2:89268001-89268506 (-) GRCh38

Human Ortholog

IGKV1-37, immunoglobulin kappa variable 1-37 (non-functional)
Synonyms

IGKV137, O14
Links

HGNC:5739

NCBI Gene ID: 28931

UniProt: A0A075B6S9
Chr Location

2p11.2; chr2:89297264-89297785 (-) GRCh38

Human Ortholog

IGKV1-5, immunoglobulin kappa variable 1-5
Synonyms

IGKV, IGKV15, L12, L12a, V1
Links

HGNC:5741

NCBI Gene ID: 28299

UniProt: P01602
Chr Location

2p11.2; chr2:88947301-88947957 (-) GRCh38

Human Ortholog

IGKV1D-12, immunoglobulin kappa variable 1D-12
Synonyms

IGKV1D12, L19
Links

HGNC:5746

NCBI Gene ID: 28903

UniProt: P01611
Chr Location

2p11.2; chr2:90159840-90160335 (+) GRCh38

Human Ortholog

IGKV1D-16, immunoglobulin kappa variable 1D-16
Synonyms

IGKV1D16, L15, L15a
Links

HGNC:5748

NCBI Gene ID: 28901
Chr Location

2p11.2; chr2:90100236-90100738 (+) GRCh38

Human Ortholog

IGKV1D-33, immunoglobulin kappa variable 1D-33
Synonyms

IGKV1D33, O8
Links

HGNC:5753

NCBI Gene ID: 28896

UniProt: P01593
Chr Location

2p11.2; chr2:89913982-89914545 (+) GRCh38

Human Ortholog

IGKV1D-37, immunoglobulin kappa variable 1D-37 (non-functional)
Synonyms

IGKV1D37, O4
Links

HGNC:5755

NCBI Gene ID: 28894

UniProt: P0DSN7
Chr Location

2p11.2; chr2:89884740-89885216 (+) GRCh38

Human Ortholog

IGKV1OR2-108, immunoglobulin kappa variable 1/OR2-108 (non-functional)
Synonyms

IGKV1OR2108, IGO1
Links

HGNC:5767

NCBI Gene ID: 28862
Chr Location

2q12-q14; chr2:113406396-113406872 (+) GRCh38

MGI Vertebrate Homology

Igkv15-103 stringent orthology
12 human;1 mouse
HCOP

vertebrate homology predictions: IGKC, IGKV1-12, IGKV1-16, IGKV1-27, IGKV1-33, IGKV1-37, IGKV1-5, IGKV1D-12, IGKV1D-16, IGKV1D-33, IGKV1D-37, IGKV1OR2-108
Gene Tree

Igkv15-103

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All GO Annotations

4
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

2

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

24
RefSeq

1
UniProt

1

Ensembl

ENSMUSG00000076523 (Evidence)
NCBI Gene

692169

			Length	Strain/Species	Flank
genomic	692169	NCBI Gene Model \| MGI Sequence Detail	458	C57BL/6J	± kb
transcript	M33992	GenBank \| ENA \| DDBJ \| MGI Sequence Detail	349	BXSB
polypeptide	A0A140T8P3	UniProt \| EBI \| MGI Sequence Detail	115	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR013106 Immunoglobulin V-set domain

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All nucleic 15

Genomic 12

cDNA 2

Primer pair 1

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MGD-MRK-11316

Summaries

All 14

Gene Ontology 2
Earliest

J:37729 Leahy DJ, et al., Sequences of 12 monoclonal anti-dinitrophenyl spin-label antibodies for NMR studies. Proc Natl Acad Sci U S A. 1988 Jun;85(11):3661-5
Latest

J:164272 Giudicelli V, et al., IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucleic Acids Res. 2005 Jan 1;33(Database issue):D256-61

TSS for Igkv15-103:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56924	Chr6:68414401-68414436 (+)	-33 bp
Tssr56925	Chr6:68414860-68414876 (+)	416 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23