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If1 Gene Detail
Summary
  • Symbol
    If1
  • Name
    NDV-induced circulating interferon
  • Synonyms
    If-1
  • Feature Type
    heritable phenotypic marker
  • IDs
    MGI:96420
    NCBI Gene: 110305
  • Alliance
Location &
Maps
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  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 3, Syntenic
  • Mapping Data
    9 experiments
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
A 7-10X difference between C57BL/6 and BALB/c mice in circulating interferon in response to Newcastle disease virus (NDV) is attributed to this locus. Quantitative expression of cytokine genes Tnf and Il6 in response to NDV is also affected. The phenotype can be transferred with bone marrow cells.
Sequences &
Gene Models
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Other
Accession IDs
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MGD-MRK-11190, MGD-MRK-11195
References
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  • Summaries
    All 18
    Phenotypes 4
  • Earliest
    J:5113 Maeyer E de, et al., Gene with quantitative effect on circulating interferon induced by Newcastle disease virus. J Virol. 1969 May;3(5):506-12
  • Latest
    J:121574 Aly M, et al., Complex genetic control of host susceptibility to coxsackievirus B3-induced myocarditis. Genes Immun. 2007 Apr;8(3):193-204

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory