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H2-T18 Gene Detail
Summary
  • Symbol
    H2-T18
  • Name
    histocompatibility 2, T region locus 18
  • Synonyms
    H-2T18, Tla, TL Ag
  • Feature Type
    unclassified gene
  • IDs
    MGI:95950
  • Alliance
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 17, Syntenic
  • Mapping Data
    19 experiments
Strain
Comparison
more
  • Strain Annotations
    1
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95950
unclassified gene Chr17:35428101-35428139 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from multigenic genotypes
    18 phenotype references
This locus contains the coding member of a gene pair encoding the thymic leukemia antigen or TL antigen in "d haplotype" mice such as BALB/c. The other member of this gene pair, H2-T3d, is a pseudogene.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Expression
less
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
  • All Sequences
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
transcript AK153910 GenBank | EMBL | DDBJ | MGI Sequence Detail 2105 NOD  
polypeptide Q3U531 UniProt | EBI | MGI Sequence Detail 340 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
    IPR011161 MHC class I-like antigen recognition-like
    IPR037055 MHC class I-like antigen recognition-like superfamily
Molecular
Reagents
less
  • All nucleic 25
    Genomic 19
    cDNA 3
    Other 3

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-10433, MGD-MRK-10546, MGD-MRK-15131
References
more
  • Summaries
    All 65
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 18
  • Earliest
    J:13118 BOYSE EA, et al., GENETIC DETERMINATION OF THE TL (THYMUSLEUKAEMIA) ANTIGEN IN THE MOUSE. Nature. 1964 Feb 22;201:779
  • Latest
    J:279912 Peterson KR, et al., Impaired insulin signaling in the B10.D2-Hc(0) H2(d) H2-T18(c)/oSnJ mouse model of complement factor 5 deficiency. Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E200-E211

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/13/2020
MGI 6.16
The Jackson Laboratory