H2-T18 Gene Detail

Summary

• Symbol
  H2-T18
• Name
  histocompatibility 2, T region locus 18
• Synonyms
  H-2T18, Tla, TL Ag

• Feature Type
  unclassified gene
• IDs
  MGI:95950
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 17, Syntenic
• Mapping Data
  19 experiments

Strain
Comparison

• RFLP
  7

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  9 phenotypes from multigenic genotypes
  22 phenotype references
  

• All Mutations and Alleles
  7
• Targeted
  1
• Find Mice (IMSR)
  52 strains or lines available

This locus contains the coding member of a gene pair encoding the thymic leukemia antigen or TL antigen in "d haplotype" mice such as BALB/c. The other member of this gene pair, H2-T3^d, is a pseudogene.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  2
• GO References
  1

Expression

• cDNA Data
  2
• Literature Summary
  1

Sequences &
Gene Models

• All Sequences
  5
• UniProt
  2

Representative Sequences			Length	Strain/Species
transcript	AK153910	GenBank | ENA | DDBJ | MGI Sequence Detail	2105	NOD
polypeptide	Q3U531	UniProt | EBI | MGI Sequence Detail	340	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• InterPro Domains
  IPR003597 Immunoglobulin C1-set
  IPR007110 Immunoglobulin-like domain
  IPR036179 Immunoglobulin-like domain superfamily
  IPR013783 Immunoglobulin-like fold
  IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
  IPR011162 MHC classes I/II-like antigen recognition protein
  IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
  IPR011161 MHC class I-like antigen recognition-like
  IPR037055 MHC class I-like antigen recognition-like superfamily

Molecular
Reagents

• All nucleic 25

  Genomic 19

  cDNA 3

  Other 3

  
  

  Microarray probesets 2

Other
Accession IDs

MGD-MRK-10433, MGD-MRK-10546, MGD-MRK-15131

References

• Summaries
  All 69

  Developmental Gene Expression 1

  Gene Ontology 1

  Phenotypes 22
• Earliest
  J:13118 BOYSE EA, et al., GENETIC DETERMINATION OF THE TL (THYMUSLEUKAEMIA) ANTIGEN IN THE MOUSE. Nature. 1964 Feb 22;201:779
• Latest
  J:316687 Walbaum S, et al., Complement receptor 3 mediates both sinking phagocytosis and phagocytic cup formation via distinct mechanisms. J Biol Chem. 2021 Jan-Jun;296:100256