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Gpt Gene Detail
Summary
  • Symbol
    Gpt
  • Name
    glutamic pyruvic transaminase, soluble
  • Synonyms
    1300007J06Rik, 2310022B03Rik, ALT, Gpt1, Gpt-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95802
    NCBI Gene: 76282
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:76696726-76699675 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 36.28 cM, cytoband D3
  • Mapping Data
    30 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95802
protein coding gene Chr15:76695716-76699686 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022007
protein coding gene Chr15:76798851-76801764 (+)
A/J MGP_AJ_G0021965
protein coding gene Chr15:73984077-73986961 (+)
AKR/J MGP_AKRJ_G0021948
protein coding gene Chr15:75992657-75995558 (+)
BALB/cJ MGP_BALBcJ_G0021974
protein coding gene Chr15:74009801-74012725 (+)
C3H/HeJ MGP_C3HHeJ_G0021746
protein coding gene Chr15:76039925-76042844 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022414
protein coding gene Chr15:79660016-79662931 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019943
protein coding gene Chr15:70642739-70645625 (+)
CAST/EiJ MGP_CASTEiJ_G0021265
protein coding gene Chr15:76846281-76849240 (+)
CBA/J MGP_CBAJ_G0021713
protein coding gene Chr15:82181646-82184577 (+)
DBA/2J MGP_DBA2J_G0021838
protein coding gene Chr15:73521264-73525229 (+)
FVB/NJ MGP_FVBNJ_G0021818
protein coding gene Chr15:72580307-72583226 (+)
LP/J MGP_LPJ_G0021909
protein coding gene Chr15:76879926-76882877 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021843
protein coding gene Chr15:87523800-87532215 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022434
protein coding gene Chr15:76267324-76270277 (+)
PWK/PhJ MGP_PWKPhJ_G0021006
protein coding gene Chr15:73687682-73690611 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020846
protein coding gene Chr15:75962127-75965960 (+)
WSB/EiJ MGP_WSBEiJ_G0021317
protein coding gene Chr15:76358540-76361449 (+)



Homology
more
  • Human Ortholog
    GPT, glutamic--pyruvic transaminase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GPT, glutamic--pyruvic transaminase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AAT1, ALT1, GPT1
  • Links
    NCBI Gene ID: 2875
    neXtProt AC: NX_P24298
    UniProt: P24298

  • Chr Location
    8q24.3; chr8:144502217-144507174 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    3
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    5 involving Gpt
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Electrophoretic variants are detected in C57BL/6, BALB/c and DBA/2 (a allele); in MA/J and NZB/Bl (b allele). M. m. molossinus and M. m. castaneus have either the b or c allele. In liver, GPT1 activity rises dramatically at 12-19 days to adult levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 76282 NCBI Gene Model | MGI Sequence Detail 2950 C57BL/6J ±  kb
transcript NM_182805 RefSeq | MGI Sequence Detail 1809 C57BL/6  
polypeptide Q8QZR5 UniProt | EBI | MGI Sequence Detail 496 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10236, MGD-MRK-10237, MGI:1915263, MGI:1923532
References
more
  • Summaries
    All 73
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 5
    Phenotypes 27
  • Earliest
    J:5384 Chen SH, et al., The genetics of glutamic-pyruvic transaminase in mice: inheritance, electrophoretic phenotypes, and postnatal changes. Biochem Genet. 1973 Sep;10(1):23-8
  • Latest
    J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory