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Fv4 Gene Detail
Summary
  • Symbol
    Fv4
  • Name
    Friend virus susceptibility 4
  • Synonyms
    Akvr-1, Fv-4
  • Feature Type
    heritable phenotypic marker
  • IDs
    MGI:95598
    NCBI Gene: 14352
  • Alliance
Location &
Maps
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  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 12, Syntenic
  • Mapping Data
    11 experiments
Strain
Comparison
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  • RFLP
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Strain G and wild mice have a dominant resistant allele to AKR and NB-tropic, but not amphotropic, leukemia viruses. DNA of these mice hybridizes to ecotropic env-gene probes suggesting resistance via a gp70 related protein binding to exogenous virus. DBA/2, BALB/c and most inbreds are susceptible.
Expression
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  • Other Mouse Links
Sequences &
Gene Models
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  • All Sequences
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic AH001894 GenBank | ENA | DDBJ | MGI Sequence Detail 3609 BALB/c (Fu-r-4w) congenic* ±  kb
polypeptide P11370 UniProt | EBI | MGI Sequence Detail 679 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 13
    Genomic 11
    Other 2
Other
Accession IDs
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MGD-MRK-1265, MGD-MRK-9898, MGD-MRK-9904
References
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  • Summaries
    All 33
    Phenotypes 9
  • Earliest
    J:5684 Suzuki S, FV-4: a new gene affecting the splenomegaly induction by Friend leukemia virus. Jpn J Exp Med. 1975 Dec;45(6):473-8
  • Latest
    J:132592 Ikeda H, et al., Virological properties and nucleotide sequences of Cas-E-type endogenous ecotropic murine leukemia viruses in South Asian wild mice, Mus musculus castaneus. J Virol. 2001 Jun;75(11):5049-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory