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f Gene Detail
Summary
  • Symbol
    f
  • Name
    flexed-tail
  • Feature Type
    heritable phenotypic marker
  • IDs
    MGI:95473
  • Alliance
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 13, Syntenic
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • RFLP
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 1 allele in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants for the spontaneous recessive flexed-tail allele have axial skeletal abnormalities, abnormal heme biosynthesis, and a transient sideroblastic anemia that disappears a few weeks after birth. The tail and belly spot phenotypes have variable penetrance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Molecular
Reagents
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  • All nucleic 1
    cDNA 1
References
more
  • Summaries
    All 27
    Gene Ontology 1
    Phenotypes 25
  • Earliest
    J:12951 Hunt HR, et al., Flexed Tail in the Mouse, Mus Musculus. Genetics. 1933 Jul;18(4):335-66
  • Latest
    J:151008 Lenox LE, et al., Extramedullary erythropoiesis in the adult liver requires BMP-4/Smad5-dependent signaling. Exp Hematol. 2009 May;37(5):549-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory