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Eif4b Gene Detail
Summary
  • Symbol
    Eif4b
  • Name
    eukaryotic translation initiation factor 4B
  • Synonyms
    2310046H11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:95304
    NCBI Gene: 75705
  • Gene Overview
    MyGene.info: EIF4B
Location & Maps
more
  • Sequence Map
    Chr15:102073773-102097172 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23400 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 57.26 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    EIF4B, eukaryotic translation initiation factor 4B
  • Vertebrate Orthologs
    11
  • Human Ortholog
    EIF4B, eukaryotic translation initiation factor 4B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EIF-4B, PRO1843
  • Links
    NCBI Gene ID: 1975
    neXtProt AC: NX_P23588

  • Chr Location
    12q13.13; chr12:53006258-53042209 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 83162
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EIF4B
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotype references
  • All Mutations and Alleles
    177
  • Chemically induced (other)
    1
  • Gene trapped
    174
  • Radiation induced
    2
  • Genomic Mutations
    3 involving Eif4b
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058655 Ensembl Gene Model | MGI Sequence Detail 23400 C57BL/6J ±  kb
transcript ENSMUST00000169681 Ensembl | MGI Sequence Detail 3853 Not Applicable  
polypeptide ENSMUSP00000127774 Ensembl | MGI Sequence Detail 611 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    129 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 20

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-9338, MGI:1922955, MGI:2146118, MGI:2146304
References
more
  • Summaries
    All 31
    Diseases 1
    Gene Ontology 5
    Phenotypes 26
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory