Dlx1 MGI Mouse Gene Detail - MGI:94901

Dlx1 Gene Detail

Symbol

Dlx1
Name

distal-less homeobox 1
Synonyms

DII B, Dlx, Dlx-1

Feature Type

protein coding gene
IDs

MGI:94901
NCBI Gene: 13390
Gene Overview

MyGene.info: DLX1

Sequence Map

Chr2:71528113-71533981 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

5869 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 42.61 cM
Mapping Data

2 experiments

Human Ortholog

DLX1, distal-less homeobox 1

Vertebrate Orthologs

10

Human Ortholog

DLX1, distal-less homeobox 1
Orthology source: HomoloGene, HGNC
Links

HGNC:2914

NCBI Gene ID: 1745

neXtProt AC: NX_P56177
Chr Location

2q32; chr2:172085480-172089674 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 22558
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: DLX1
Gene Tree

Dlx1

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Phenotype Summary

8 phenotypes from 1 allele in 2 genetic backgrounds
13 phenotypes from multigenic genotypes
50 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Targeted

6
Genomic Mutations

2 involving Dlx1

Homozygous null mutants show morphogenetic abnormalities in first and second branchial arch-derived proximal skeletal and soft tissue structures; in double mutants with a Dlx2 null allele, maxillary molar teeth are missing.

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All GO Annotations

25
GO References

14

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

924
Tissues

380
cDNA Data

18
Literature Summary

159

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO
Other Vertebrate Links

GEISHA DLX1

Xenbase dlx1

ZFIN dlx1a

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Dlx1 interacts with 184 markers (Mir7-2, Mir7b, Mir9-1, ...) View All

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All Sequences

51
RefSeq

14
UniProt

6
CCDS

CCDS16116.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000013200	VEGA Gene Model \| MGI Sequence Detail	5869	C57BL/6J	± kb
transcript	OTTMUST00000031898	VEGA \| MGI Sequence Detail	4111	Not Applicable
polypeptide	OTTMUSP00000014202	VEGA \| MGI Sequence Detail	255	Not Applicable

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SNPs within 2kb

49 from dbSNP Build 142

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UniProt

6 Sequences
Protein Ontology

PR:000006527 homeobox protein DLX-1
InterPro Domains

IPR000047 Helix-turn-helix motif

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR009057 Homeodomain-like

IPR020479 Homeodomain, metazoa

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All nucleic 38

Genomic 6

cDNA 20

Primer pair 2

Other 10

Microarray probesets 3

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MGD-MRK-8857, MGD-MRK-8861

Summaries

All 207

Developmental Gene Expression 159

Gene Ontology 14

Phenotypes 50
Earliest

J:11292 Price M, et al., A mouse gene related to Distal-less shows a restricted expression in the developing forebrain. Nature. 1991 Jun 27;351(6329):748-51
Latest

J:233607 Villette V, et al., Development of early-born gamma-Aminobutyric acid hub neurons in mouse hippocampus from embryogenesis to adulthood. J Comp Neurol. 2016 Aug 15;524(12):2440-61

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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