About   Help   FAQ
Dlx1
Gene Detail
 Symbol
Name
ID
Dlx1
distal-less homeobox 1
MGI:94901
Synonyms DII B, Dlx, Dlx-1
Feature Type protein coding gene
Genetic Map
Chromosome 2
42.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:71528113-71533981 bp, + strand
From VEGA annotation of GRCm38

  5869 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22558  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dlx1

Human
homologs
Human Homolog DLX1, distal-less homeobox 1
NCBI Gene ID 1745
neXtProt AC  NX_P56177
Human Chr (Location)  2q32; chr2:172085480-172089674 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Homozygous null mutants show morphogenetic abnormalities in first and second branchial arch-derived proximal skeletal and soft tissue structures; in double mutants with a Dlx2 null allele, maxillary molar teeth are missing.
 
Interactions
Dlx1 interacts with 184 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell differentiation, cerebral cortex GABAergic interneuron differentiation, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (148 records)
Data Summary: Results (907)    Tissues (372)    Images (250)
Theiler Stages: 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 61
RNA in situ 814
Northern blot 11
RT-PCR 2
RNase protection 19
cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) Genomic(6) cDNA(19) Primer pair(2) Other(10)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000013200 (Evidence)
Ensembl Gene ModelENSMUSG00000041911 (Evidence)
Entrez Gene13390 (Evidence)
DFCITC1584438, TC1605288
NIA Mouse Gene IndexU001904
Consensus CDS ProjectCCDS16116.1
International Mouse Knockout Project StatusDlx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013200 VEGA Gene Model | MGI Sequence Detail 5869 C57BL/6J ±  kb
transcript OTTMUST00000031898 VEGA | MGI Sequence Detail 4111 Not Applicable 
polypeptide OTTMUSP00000014202 VEGA | MGI Sequence Detail 255 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(8) UniProt(6)
Polymorphisms SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000006527 homeobox protein DLX-1
References (Earliest) J:11292 Price M, et al., A mouse gene related to Distal-less shows a restricted expression in the developing forebrain. Nature. 1991 Jun 27;351(6329):748-51
(Latest) J:206289 Howard MA, et al., Bidirectional homeostatic plasticity induced by interneuron cell death and transplantation in vivo. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):492-7
All references(199)
Other
accession IDs
MGD-MRK-8857, MGD-MRK-8861

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory