Dlx1 MGI Mouse Gene Detail - MGI:94901

Symbol

Dlx1
Name

distal-less homeobox 1
Synonyms

DII B, Dlx, Dlx-1

Feature Type

protein coding gene
IDs

MGI:94901
NCBI Gene: 13390
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr2:71358457-71364325 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 42.61 cM
Mapping Data

2 experiments

SNPs within 2kb

41 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_94901	protein coding gene	Chr2:71358457-71364325 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025824	protein coding gene	Chr2:71646383-71652251 (+)
A/J	MGP_AJ_G0025802	protein coding gene	Chr2:68841312-68847182 (+)
AKR/J	MGP_AKRJ_G0025770	protein coding gene	Chr2:70731531-70737401 (+)
BALB/cJ	MGP_BALBcJ_G0025796	protein coding gene	Chr2:69029877-69035745 (+)
C3H/HeJ	MGP_C3HHeJ_G0025556	protein coding gene	Chr2:70938330-70944192 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026243	protein coding gene	Chr2:73807044-73812912 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023646	protein coding gene	Chr2:66065371-66071258 (+)
CAST/EiJ	MGP_CASTEiJ_G0025020	protein coding gene	Chr2:71127095-71132993 (+)
CBA/J	MGP_CBAJ_G0025537	protein coding gene	Chr2:76526107-76531975 (+)
DBA/2J	MGP_DBA2J_G0025668	protein coding gene	Chr2:68480274-68486144 (+)
FVB/NJ	MGP_FVBNJ_G0025630	protein coding gene	Chr2:67869429-67875299 (+)
LP/J	MGP_LPJ_G0025756	protein coding gene	Chr2:71505770-71511638 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025661	protein coding gene	Chr2:78513047-78518917 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026300	protein coding gene	Chr2:70835480-70841348 (+)
PWK/PhJ	MGP_PWKPhJ_G0024761	protein coding gene	Chr2:68351960-68357851 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024569	protein coding gene	Chr2:71023242-71029116 (+)
WSB/EiJ	MGP_WSBEiJ_G0025088	protein coding gene	Chr2:71268834-71274702 (+)

Human Ortholog

DLX1, distal-less homeobox 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DLX1, distal-less homeobox 1
Links

HGNC:2914

NCBI Gene ID: 1745

neXtProt AC: NX_P56177

UniProt: P56177
Chr Location

2q31.1; chr2:172085480-172089674 (+) GRCh38.p7

Alliance of Genome Resources

Dlx1 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: DLX1
Gene Tree

Dlx1

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Phenotype Summary

10 phenotypes from 1 allele in 2 genetic backgrounds
13 phenotypes from multigenic genotypes
69 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Targeted

6
Genomic Mutations

2 involving Dlx1
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mutants show morphogenetic abnormalities in first and second branchial arch-derived proximal skeletal and soft tissue structures; in double mutants with a Dlx2 null allele, maxillary molar teeth are missing.

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All GO Annotations

51
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1711
Tissues

408
cDNA Data

22
Literature Summary

197

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA DLX1

Xenbase dlx1

ZFIN dlx1a

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Dlx1 interacts with 184 markers (Mir7-2, Mir7b, Mir9-1, ...) View All

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All Sequences

52
RefSeq

8
UniProt

6
CCDS

CCDS16116.1

Ensembl

ENSMUSG00000041911 (Evidence)
NCBI Gene

13390

			Length	Strain/Species	Flank
genomic	13390	NCBI Gene Model \| MGI Sequence Detail	5869	C57BL/6J	± kb
transcript	NM_010053	RefSeq \| MGI Sequence Detail	2794	C57BL/6
polypeptide	Q64317	UniProt \| EBI \| MGI Sequence Detail	255	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000006527 homeobox protein DLX-1

(term hierarchy)
InterPro Domains

IPR000047 Helix-turn-helix motif

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR020479 Homeobox domain, metazoa

IPR009057 Homeobox-like domain superfamily

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All nucleic 50

Genomic 6

cDNA 25

Primer pair 6

Other 13

Microarray probesets 3

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MGD-MRK-8857, MGD-MRK-8861

Summaries

All 285

Developmental Gene Expression 197

Gene Ontology 17

Phenotypes 69
Earliest

J:11292 Price M, et al., A mouse gene related to Distal-less shows a restricted expression in the developing forebrain. Nature. 1991 Jun 27;351(6329):748-51
Latest

J:325504 Price JD, et al., DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression. Development. 2022 Jun 1;149(11):dev199508

TSS for Dlx1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18267	Chr2:71358861-71358874 (+)	411 bp
Tssr18268	Chr2:71358882-71358891 (+)	430 bp
Tssr18269	Chr2:71358947-71358989 (+)	511 bp
Tssr18270	Chr2:71359001-71359012 (+)	550 bp
Tssr18271	Chr2:71359422-71359428 (+)	968 bp
Tssr18272	Chr2:71359429-71359454 (+)	985 bp
Tssr18273	Chr2:71359892-71359908 (+)	1,443 bp
Tssr18274	Chr2:71359933-71359945 (+)	1,482 bp
Tssr18275	Chr2:71360142-71360151 (+)	1,690 bp
Tssr18276	Chr2:71360158-71360185 (+)	1,715 bp
Tssr18277	Chr2:71360244-71360247 (+)	1,789 bp
Tssr18278	Chr2:71360266-71360280 (+)	1,816 bp
Tssr518	Chr2:71360312-71360317 (+)	1,858 bp
Tssr18279	Chr2:71361073-71361100 (+)	2,630 bp
Tssr18280	Chr2:71361102-71361123 (+)	2,656 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/23/2022 MGI 6.20