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Dlx1 Gene Detail
Summary
  • Symbol
    Dlx1
  • Name
    distal-less homeobox 1
  • Synonyms
    DII B, Dlx, Dlx-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:94901
    NCBI Gene: 13390
  • Gene Overview
    MyGene.info: DLX1
Location & Maps
more
  • Sequence Map
    Chr2:71528113-71533981 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      5869 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 42.61 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DLX1, distal-less homeobox 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DLX1, distal-less homeobox 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 1745
    neXtProt AC: NX_P56177
    UniProt: P56177

  • Chr Location
    2q31.1; chr2:172085480-172089674 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 22558
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DLX1
  • Gene Tree
    Dlx1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants show morphogenetic abnormalities in first and second branchial arch-derived proximal skeletal and soft tissue structures; in double mutants with a Dlx2 null allele, maxillary molar teeth are missing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    39
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    932
  • Tissues
    380
  • cDNA Data
    18
  • Literature Summary
    165
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013200 VEGA Gene Model | MGI Sequence Detail 5869 C57BL/6J ±  kb
transcript OTTMUST00000031898 VEGA | MGI Sequence Detail 4111 Not Applicable  
polypeptide OTTMUSP00000014202 VEGA | MGI Sequence Detail 255 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    49 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    Genomic 6
    cDNA 20
    Primer pair 2
    Other 10

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-8857, MGD-MRK-8861
References
more
  • Summaries
    All 227
    Developmental Gene Expression 165
    Gene Ontology 16
    Phenotypes 51
  • Earliest
    J:11292 Price M, et al., A mouse gene related to Distal-less shows a restricted expression in the developing forebrain. Nature. 1991 Jun 27;351(6329):748-51
  • Latest
    J:241572 Zhang Q, et al., Regulation of Brn3b by DLX1 and DLX2 is required for retinal ganglion cell differentiation in the vertebrate retina. Development. 2017 May 01;144(9):1698-1711
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
08/15/2017
MGI 6.10 		The Jackson Laboratory