Dlx1
Gene Detail

Symbol

Name
ID

Dlx1
distal-less homeobox 1
MGI:94901

Synonyms

DII B, Dlx, Dlx-1

Feature Type

protein coding gene

Genetic Map

Chromosome 2
42.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:71528113-71533981 bp, + strand From VEGA annotation of GRCm38   5869 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:22558  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dlx1

Human
homologs

Human Homolog		DLX1, distal-less homeobox 1
NCBI Gene ID		1745
neXtProt AC		NX_P56177
Human Chr (Location)		2q32; chr2:172085480-172089674 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Dlx1 (1)
 

Homozygous null mutants show morphogenetic abnormalities in first and second branchial arch-derived proximal skeletal and soft tissue structures; in double mutants with a Dlx2 null allele, maxillary molar teeth are missing.

 

Interactions

Dlx1 interacts with 184 markers (Mir7-2, Mir7b, Mir9-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (25 annotations)

Process	cell differentiation, cerebral cortex GABAergic interneuron differentiation, ...
Component	nucleus
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (152 records)

Data Summary: Results (907)    Tissues (372)    Images (250)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	61
RNA in situ	814
Northern blot	11
RT-PCR	2
RNase protection	19

cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(37) Genomic(6) cDNA(19) Primer pair(2) Other(10)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000013200 (Evidence)
Ensembl Gene Model	ENSMUSG00000041911 (Evidence)
Entrez Gene	13390 (Evidence)
DFCI	TC1584438, TC1605288
NIA Mouse Gene Index	U001904
Consensus CDS Project	CCDS16116.1
International Mouse Knockout Project Status	Dlx1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000013200	VEGA Gene Model | MGI Sequence Detail	5869	C57BL/6J
transcript	OTTMUST00000031898	VEGA | MGI Sequence Detail	4111	Not Applicable
polypeptide	OTTMUSP00000014202	VEGA | MGI Sequence Detail	255	Not Applicable

All sequences(54) RefSeq(8) UniProt(11)

Polymorphisms

SNPs within 2kb(48 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR000047	Helix-turn-helix motif
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000006527	homeobox protein DLX-1

References

(Earliest) J:11292 Price M, et al., A mouse gene related to Distal-less shows a restricted expression in the developing forebrain. Nature. 1991 Jun 27;351(6329):748-51
(Latest) J:214763 He F, et al., Directed Bmp4 expression in neural crest cells generates a genetic model for the rare human bony syngnathia birth defect. Dev Biol. 2014 Jul 15;391(2):170-81
All references(204)

Other
accession IDs

MGD-MRK-8857, MGD-MRK-8861