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Dbf Gene Detail
Summary
  • Symbol
    Dbf
  • Name
    doublefoot
  • Feature Type
    heritable phenotypic marker
  • IDs
    MGI:94863
    NCBI Gene: 109578
Location & Maps
more
  • Genetic Map
    Chromosome 1, Syntenic
  • Mapping Data
    7 experiments
Human Diseases
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  • Diseases
    1 with Dbf mouse models

Human Disease Mouse Models
       Clubfoot, Congenital, with or without Deficiency of Long Bones and/or Mirror-Image Polydactyly; CCF   OMIM: 119800 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    59 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    1
  • Spontaneous
    1
Homozygous mutants die late in emrbyonic development with split face, bulged heads and edema; heterozygotes have severe limb defects with duplicate toes on all feet, hindlimb shortening, broad skulls, clubbed feet, and reduced viability and fertility.
Sequences &
Gene Models
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Other
Accession IDs
less
MGD-MRK-8800
References
more
  • Summaries
    All 12
    Diseases 1
    Phenotypes 8
  • Earliest
    J:14233 Lyon MF, et al., Doublefoot, a new mutation affecting limb development. Mouse News Lett. 1989;83:158
  • Latest
    J:135300 Babbs C, et al., Polydactyly in the mouse mutant Doublefoot involves altered Gli3 processing and is caused by a large deletion in cis to Indian hedgehog. Mech Dev. 2008 May-Jun;125(5-6):517-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory