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Pirb
Gene Detail
 Symbol
Name
ID
Pirb
paired Ig-like receptor B
MGI:894311
Synonyms Gp91, Lilrb3
Feature Type protein coding gene
Genetic Map
Chromosome 7
2.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:3711409-3720391 bp, - strand
From VEGA annotation of GRCm38

  8983 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134028  Vertebrate Homology Class
1 human; 7 mouse; 2 rat; 1 chimpanzee; 1 dog

Gene Tree: Pirb

Human
homologs
Human Homolog LILRB3, leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
NCBI Gene ID 11025
neXtProt AC  NX_Q6PI73
Human Synonyms  CD85A, HL9, ILT5, ILT-5, LILRA6, LIR3, LIR-3, PIRB
Human Chr (Location)  19q13.4; chr19:54216278-54223087 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene display abnormalities in both B and T lymphocytes.
 
Interactions
Pirb interacts with 234 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process B cell homeostasis, B cell mediated immunity, ...
Component integral component of membrane, membrane, ...
External Resources: FuncBase
Expression
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(18)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000020499 (Evidence)
Ensembl Gene ModelENSMUSG00000058818 (Evidence)
Entrez Gene18733 (Evidence)
Consensus CDS ProjectCCDS39730.1
International Mouse Knockout Project StatusPirb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020499 VEGA Gene Model | MGI Sequence Detail 8983 C57BL/6J ±  kb
transcript OTTMUST00000048614 VEGA | MGI Sequence Detail 3824 Not Applicable 
polypeptide OTTMUSP00000022330 VEGA | MGI Sequence Detail 841 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(11) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(196 from dbSNP Build 137)    SNPs within 2kb including multiple locations(340)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
Protein Ontology PR:000009810 leukocyte immunoglobulin-like receptor subfamily B member 3
References (Earliest) J:39238 Hayami K, et al., Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors. J Biol Chem. 1997 Mar 14;272(11):7320-7
(Latest) J:208993 Ben Baruch-Morgenstern N, et al., Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil development. Nat Immunol. 2014 Jan;15(1):36-44
All references(56)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory