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Pirb Gene Detail
Summary
  • Symbol
    Pirb
  • Name
    paired Ig-like receptor B
  • Synonyms
    Gp91, Lilrb3
  • Feature Type
    protein coding gene
  • IDs
    MGI:894311
    NCBI Gene: 18733
  • Gene Overview
    MyGene.info: LILRB3
Location & Maps
more
  • Genetic Map
    Chromosome 7, 2.14 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LILRB3, leukocyte immunoglobulin like receptor B3
  • Vertebrate Orthologs
    12
  • Human Ortholog
    LILRB3, leukocyte immunoglobulin like receptor B3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD85A, HL9, ILT5, ILT-5, LILRA6, LIR3, LIR-3, PIRB, PIR-B
  • Links
    NCBI Gene ID: 11025
    neXtProt AC: NX_Q6PI73

  • Chr Location
    19q13.42; chr19:54216278-54223087 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene display abnormalities in both B and T lymphocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020499 VEGA Gene Model | MGI Sequence Detail 8983 C57BL/6J ±  kb
transcript OTTMUST00000048614 VEGA | MGI Sequence Detail 3824 Not Applicable  
polypeptide OTTMUSP00000022330 VEGA | MGI Sequence Detail 841 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    141 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 19
    Genomic 1
    cDNA 18

    Microarray probesets 5
References
more
  • Summaries
    All 60
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 30
  • Earliest
    J:39238 Hayami K, et al., Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors. J Biol Chem. 1997 Mar 14;272(11):7320-7
  • Latest
    J:225778 Bochner DN, et al., Blocking PirB up-regulates spines and functional synapses to unlock visual cortical plasticity and facilitate recovery from amblyopia. Sci Transl Med. 2014 Oct 15;6(258):258ra140

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory