Tir1 QTL Detail

Summary

• Symbol
  Tir1
• Name
  trypanosome infection response 1

• Feature Type
  QTL
• IDs
  MGI:892966
  NCBI Gene: 110283
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 17, 17.98 cM (cM position of peak correlated region/marker)
• Mapping Data
  5 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotype references
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  110283

References

• Summaries
  All 14

  Phenotypes 4
• Earliest
  J:37769 Proceedings of the 25th International Conference on Animal Genetics. Tours, France, 21-25 July 1996. Teale A, et al., Proceedings of the 25th International Conference on Animal Genetics. Tours, France, 21-25 July 1996. Abstracts. Anim Genet. 1996 Dec;27 Suppl 2:1-124 (5-6 Abstr.)
• Latest
  J:152225 Rathkolb B, et al., Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection. Infect Immun. 2009 Sep;77(9):3948-57

Candidate Genes for Tir1:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Daxx	Chr17:34128388-34134564 (+)	J:125686	Candidate gene search for Tir1 (18.2 cM, chr 17), a QTL associated with resistance to Trypanosome congolense infection, was employed using a whole genome expression approach. Mice from C57BL/6 (resistant) and A/J and BALB/c (susceptible) were infected with T. congolense. RNA samples were prepared from liver, spleen, and kidney at different time intervals post-infection. Genes exhibiting differential expression and involvement in infection pathways were given priority for analysis. The Tir1 locus encompasses 344 genes. After gene expression and pathway analysis 32 candidate genes remained. Daxx at 17 cM was chosen as primary candidate because of its involvement in the apoptosis pathway. Sequence analysis revealed the presence of 3 SNPs exhibiting correlation with survival time after infection. Two of these polymorphisms are located in the Daxx 5' upstream region. The third polymorphism is a 3 nucleotide deletion resulting in the deletion of an aspartic acid residue in the susceptible A/J and BALB/c strains.