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cri Gene Detail
Summary
  • Symbol
    cri
  • Name
    cribriform degeneration
  • Feature Type
    heritable phenotypic marker
  • IDs
    MGI:88500
    NCBI Gene: 12924
  • Alliance
Location &
Maps
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  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 4, Syntenic
  • Mapping Data
    3 experiments
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous mutation exhibit normocytic anemia, electrolyte imbalance, ataxia, muscle weakness, and vacuolar degeneration of the brainstem, spinal cord, and retinal inner nuclear layer. Condition is lethal.
Sequences &
Gene Models
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Other
Accession IDs
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MGD-MRK-2143
References
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  • Summaries
    All 9
    Phenotypes 7
  • Earliest
    J:5277 Green MC, et al., Cribriform degeneration (cri): a new recessive neurological mutation in the mouse. Science. 1972 May 19;176(36):800-3
  • Latest
    J:14607 Catanzaro OL, et al., Trypsine-like esteroproteases, kinin and kininases in submandibular gland, colon and pulmonary lavage fluid of mouse model for human cystic fibrosis (CF). Adv Exp Med Biol. 1989;247B:639-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory