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C2
Gene Detail
Symbol

Name
ID
C2
complement component 2 (within H-2S)
MGI:88226
Synonyms
classical-complement pathway C3/C5 convertase
Feature Type
protein coding gene
Genetic Map
Chromosome 17
18.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr17:34862604-34898265 bp, - strand
From VEGA annotation of GRCm38

  35662 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:45  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: C2
Protein SuperFamily: complement B/C2
Gene Tree: C2

Human
homologs
C2, complement component 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 717
neXtProt AC: NX_P06681

Human Synonyms: ARMD14, CO2

Human Chr (Location): 6p21.3; chr6:31897785-31945674 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human C2

Mutations,
alleles, and
phenotypes
All mutations/alleles(74) : Gene trapped(74)
Incidental mutations (data from Mutagenetix , APF )
Interactions
C2 interacts with 56 markers (Mir28b, Mir28c, Mir30b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process complement activation, complement activation, classical pathway, ...
Component extracellular exosome, extracellular region
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (150)    Tissues (120)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 108
RT-PCR 42
cDNA source data(40)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase c2    NEW 
Molecular
reagents
All nucleic(45) Genomic(4) cDNA(40) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000034003 (Evidence)
Ensembl Gene Model ENSMUSG00000024371 (Evidence)
Entrez Gene 12263 (Evidence)
UniGene 283217
DFCI TC1576353, TC1757501
DoTS DT.101175251, DT.110557780, DT.50316850
NIA Mouse Gene Index U037726
EC 3.4.21.43
Consensus CDS Project CCDS28664.1
International Mouse Phenotyping Consortium Status C2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034003 VEGA Gene Model | MGI Sequence Detail 35662 C57BL/6J ±  kb
transcript OTTMUST00000085830 VEGA | MGI Sequence Detail 2641 Not Applicable 
polypeptide OTTMUSP00000046411 VEGA | MGI Sequence Detail 760 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(152 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011360 Complement B/C2
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR000436 Sushi/SCR/CCP
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000004899 complement C2
References
(Earliest) J:7096 Atkinson JP, et al., H-2 S region determined polymorphic variants of the C4, Slp, C2, and B complement proteins: a compilation. Immunogenetics. 1982;16(6):617-23
(Latest) J:173492 Li Q, et al., Essential Role of Factor B of the Alternative Complement Pathway in Complement Activation and Opsonophagocytosis during Acute Pneumococcal Otitis Media in Mice. Infect Immun. 2011 Jul;79(7):2578-85
All references(55)
Other
accession IDs
MGD-MRK-1699

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory