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C2 Gene Detail
Summary
  • Symbol
    C2
  • Name
    complement component 2 (within H-2S)
  • Synonyms
    classical-complement pathway C3/C5 convertase
  • Feature Type
    protein coding gene
  • IDs
    MGI:88226
    NCBI Gene: 12263
  • Gene Overview
    MyGene.info: C2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34862602-34882100 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.41 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88226
protein coding gene Chr17:34862602-34898265 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023595
protein coding gene Chr17:34974421-35016017 (-)
A/J MGP_AJ_G0023557
protein coding gene Chr17:33832811-33871954 (-)
AKR/J MGP_AKRJ_G0023523
protein coding gene Chr17:34291684-34332270 (-)
BALB/cJ MGP_BALBcJ_G0023562
protein coding gene Chr17:33963123-33998677 (-)
C3H/HeJ MGP_C3HHeJ_G0023322
protein coding gene Chr17:34691922-34729137 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024002
protein coding gene Chr17:36311731-36352883 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021481
protein coding gene Chr17:31597500-31634452 (-)
CAST/EiJ MGP_CASTEiJ_G0022820
protein coding gene Chr17:34686796-34724168 (-)
CBA/J MGP_CBAJ_G0023300
protein coding gene Chr17:37823303-37860116 (-)
DBA/2J MGP_DBA2J_G0023428
protein coding gene Chr17:33147167-33185390 (-)
FVB/NJ MGP_FVBNJ_G0023395
protein coding gene Chr17:32977415-33016924 (-)
LP/J MGP_LPJ_G0023505
protein coding gene Chr17:35285277-35337272 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023418
protein coding gene Chr17:36752045-36798794 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024044
protein coding gene Chr17:34521548-34558865 (-)
PWK/PhJ MGP_PWKPhJ_G0022569
protein coding gene Chr17:31976804-32013216 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022386
protein coding gene Chr17:32522738-32562103 (-)
WSB/EiJ MGP_WSBEiJ_G0022882
protein coding gene Chr17:34630301-34668660 (-)



Homology
more
  • Human Ortholog
    C2, complement C2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    C2, complement C2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARMD14, CO2
  • Links
    NCBI Gene ID: 717
    neXtProt AC: NX_P06681
    UniProt: P06681

  • Chr Location
    6p21.33; chr6:31897785-31945674 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human C2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12263 NCBI Gene Model | MGI Sequence Detail 19499 C57BL/6J ±  kb
transcript NM_013484 RefSeq | MGI Sequence Detail 2644 C57BL/6  
polypeptide P21180 UniProt | EBI | MGI Sequence Detail 760 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    Genomic 4
    cDNA 41
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1699
References
more
  • Summaries
    All 51
    Developmental Gene Expression 6
    Gene Ontology 4
  • Earliest
    J:6325 Gorman JC, et al., Development of a hemolytic assay for mouse C2 and determination of its genetic control. J Immunol. 1980 Jul;125(1):344-51
  • Latest
    J:221550 Abonnenc M, et al., Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ Res. 2013 Oct 25;113(10):1138-47

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/27/2018
MGI 6.13
The Jackson Laboratory