C2
Gene Detail

Symbol Name ID

C2 complement component 2 (within H-2S) MGI:88226

Synonyms

classical-complement pathway C3/C5 convertase

Feature Type

protein coding gene

Genetic Map

Chromosome 17

18.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr17:34856412-34898265 bp, - strand From VEGA annotation of GRCm38   41854 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:45  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: complement B/C2
Gene Tree: C2

Human homologs

Human Homolog		C2, complement component 2
NCBI Gene ID		717
neXtProt AC		NX_P06681
Human Synonyms		CO2
Human Chr (Location)		6p21.3; chr6:31865562-31913449 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human C2

Alleles and phenotypes

All alleles(79) : Gene trapped(79)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	complement activation, complement activation, classical pathway, ...
Component	extracellular region
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (150)    Tissues (116)    Images (25)
Theiler Stages: 16, 18, 20, 21, 23, 25, 28

Assay Type	Results
RNA in situ	108
RT-PCR	42

cDNA source data(40)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(45) Genomic(4) cDNA(40) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000034003 (Evidence)
Ensembl Gene Model	ENSMUSG00000024371 (Evidence)
Entrez Gene	12263 (Evidence)
UniGene	283217
DFCI	TC1576353, TC1757501
DoTS	DT.101175251, DT.110557780, DT.50316850
NIA Mouse Gene Index	U037726
EC	3.4.21.43
Consensus CDS Project	CCDS28664.1
International Mouse Knockout Project Status	C2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034003	VEGA Gene Model | MGI Sequence Detail	41854	C57BL/6J
transcript	OTTMUST00000085830	VEGA | MGI Sequence Detail	2641	Not Applicable
polypeptide	OTTMUSP00000046411	VEGA | MGI Sequence Detail	760	Not Applicable

All sequences(84) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(87 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011360	Complement B/C2
InterPro	IPR016060	Complement control module
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
InterPro	IPR000436	Sushi/SCR/CCP
InterPro	IPR002035	von Willebrand factor, type A
Protein Ontology	PR:000004899	complement C2

References

(Earliest) J:6325 Gorman JC, et al., Development of a hemolytic assay for mouse C2 and determination of its genetic control. J Immunol. 1980 Jul;125(1):344-51
(Latest) J:173492 Li Q, et al., Essential Role of Factor B of the Alternative Complement Pathway in Complement Activation and Opsonophagocytosis during Acute Pneumococcal Otitis Media in Mice. Infect Immun. 2011 Jul;79(7):2578-85
All references(61)

Other accession IDs

MGD-MRK-1699