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C2
Gene Detail
 Symbol
Name
ID
C2
complement component 2 (within H-2S)
MGI:88226
Synonyms classical-complement pathway C3/C5 convertase
Feature Type protein coding gene
Genetic Map
Chromosome 17
18.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr17:34862604-34898265 bp, - strand
From VEGA annotation of GRCm38

  35662 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:45  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: complement B/C2
Gene Tree: C2

Human
homologs
Human Homolog C2, complement component 2
NCBI Gene ID 717
neXtProt AC  NX_P06681
Human Synonyms  ARMD14, CO2
Human Chr (Location)  6p21.3; chr6:31897785-31945674 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human C2
Alleles
and
phenotypes
All alleles(79) : Gene trapped(79)
Incidental mutations (data from Mutagenetix , APF )
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process complement activation, complement activation, classical pathway, ...
Component extracellular region
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (150)    Tissues (116)    Images (25)
Theiler Stages: 16, 18, 20, 21, 23, 25, 28
Assay TypeResults
RNA in situ 108
RT-PCR 42
cDNA source data(40)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(45) Genomic(4) cDNA(40) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034003 (Evidence)
Ensembl Gene ModelENSMUSG00000024371 (Evidence)
Entrez Gene12263 (Evidence)
UniGene283217
DFCITC1576353, TC1757501
DoTSDT.101175251, DT.110557780, DT.50316850
NIA Mouse Gene IndexU037726
EC3.4.21.43
Consensus CDS ProjectCCDS28664.1
International Mouse Knockout Project StatusC2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034003 VEGA Gene Model | MGI Sequence Detail 35662 C57BL/6J ±  kb
transcript OTTMUST00000085830 VEGA | MGI Sequence Detail 2641 Not Applicable 
polypeptide OTTMUSP00000046411 VEGA | MGI Sequence Detail 760 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(6) UniProt(5)
Polymorphisms SNPs within 2kb(152 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011360 Complement B/C2
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR000436 Sushi/SCR/CCP
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000004899 complement C2
References (Earliest) J:6325 Gorman JC, et al., Development of a hemolytic assay for mouse C2 and determination of its genetic control. J Immunol. 1980 Jul;125(1):344-51
(Latest) J:173492 Li Q, et al., Essential Role of Factor B of the Alternative Complement Pathway in Complement Activation and Opsonophagocytosis during Acute Pneumococcal Otitis Media in Mice. Infect Immun. 2011 Jul;79(7):2578-85
All references(62)
Other
accession IDs
MGD-MRK-1699

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory