Tg(Prnp-HTT*82Q)8AGschi
Transgene Detail

Summary

• Symbol: Tg(Prnp-HTT*82Q)8AGschi
• Name: transgene insertion 8A, Gabriele Schilling
• MGI ID: MGI:6294291
• Synonyms: NLS-N171-82Q
• Transgene: Tg(Prnp-HTT*82Q)8AGschi Location: unknown
• Alliance: Tg(Prnp-HTT*82Q)8AGschi page

Transgene origin

• Strain of Origin: (C3H/HeJ x C57BL/6J)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-HTT*82Q)8AGschi expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HTT (3064)

  Htt	(MGI:96067)

  Contains a nuclear localization sequence

• Mutation details: The first 171 amino acids of human huntingtin with an expanded glutamine tract of 82 glutamines fused at the N-terminus to the nuclear localization signal sequence from atrophin-1 (first 30 amino acids) is under the control of the mouse prion protein promoter. Western blot and immunohistochemical analyses confirmed that the huntingtin fragments accumulate in nuclear, but not cytoplasmic, compartments. (J:91795)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:91795 Schilling G, et al., Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice. Hum Mol Genet. 2004 Aug 1;13(15):1599-610
• All: 1 reference(s)