Tg(PDGFB-LRRK2*R1441C)31Hlw
Transgene Detail

Summary

• Symbol: Tg(PDGFB-LRRK2*R1441C)31Hlw
• Name: transgene insertion 31, Hung-Li Wang
• MGI ID: MGI:5800408
• Synonyms: (R1441C) LRRK2
• Transgene: Tg(PDGFB-LRRK2*R1441C)31Hlw Location: unknown
• Alliance: Tg(PDGFB-LRRK2*R1441C)31Hlw page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(PDGFB-LRRK2*R1441C)31Hlw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LRRK2 (120892)

  Lrrk2

  (MGI:1913975)

• Mutation details: Human LRRK2 with the disease causing R1441C mutation with an HA tag on the C-terminus is under the control of the CMV enhancer/platelet-derived growth factor-beta chain promoter. Immunoblot analysis confirmed transgene expression in various brain regions, including the cerebral cortex, substantia nigra, and striatum. Western blot analysis indicates a 2-fold overexpression of the protein compared to the endogenous level in the substantia nigra. Two lines, 31 and 39, were established and line 31 is entered as the representative line. (J:229559)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:229559 Weng YH, et al., (R1441C) LRRK2 induces the degeneration of SN dopaminergic neurons and alters the expression of genes regulating neuronal survival in a transgenic mouse model. Exp Neurol. 2016 Jan;275 Pt 1:104-15
• All: 1 reference(s)