Tg(E2F1-luc)1Ech
Transgene Detail

Summary

• Symbol: Tg(E2F1-luc)1Ech
• Name: transgene insertion 1, Eric C Holland
• MGI ID: MGI:5648123
• Synonyms: Tg(E2F1-luc)Ubc
• Transgene: Tg(E2F1-luc)1Ech Location: unknown
• Alliance: Tg(E2F1-luc)1Ech page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The human E2F1 promoter controls the expression of a firefly luciferase gene. Bioluminescence correlates with the number of tumor cells and with the loss of RB pathway necessary for transformation activity and the proliferative capacity of tumor cells. 8 founders with germline transmission were generated; three of these showed tight cell-cycle regulation of expression in vitro. (J:93965)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:93965 Uhrbom L, et al., Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model. Nat Med. 2004 Nov;10(11):1257-1260
• All: 2 reference(s)