Tg(Myh6-2A)#Know
Transgene Detail

Summary

• Symbol: Tg(Myh6-2A)#Know
• Name: transgene insertion, Kirk Knowlton
• MGI ID: MGI:5569629
• Synonyms: 2A, alpha-MHC-IRES-FloxedLacZ-2A^Pro
• Transgene: Tg(Myh6-2A)#Know Location: unknown
• Alliance: Tg(Myh6-2A)#Know page

Transgene origin

• Strain of Origin: C57BL/6 x BALB/c

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(Myh6-2A)#Know expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myh6 (MGI:97255)

• Mutation details: The transgene contains the cardiac-specific mouse promoter, IRES, translation initiation sequence, loxP site, lacZ reporter gene with a STOP codon and polyadenylation sequence, loxP site, enteroviral protease 2a cleavage site, enteroviral protease 2a coding sequence and polyadenylation sequence. The pound symbol (#) is used when no line is specified and/or lines are pooled. Cre-mediated recombination is required to achieve expression of the protease. (J:128060)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:128060 Xiong D, et al., Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy. Circulation. 2007 Jan 2;115(1):94-102
• All: 2 reference(s)