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Rr27 Other Genome Feature Detail
Summary
  • Symbol
    Rr27
  • Name
    regulatory region 27
  • Synonyms
    DMR, ICR
  • Feature Type
    unclassified other genome feature
  • IDs
    MGI:5489785
Location &
Maps
less
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 7, Syntenic
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 18 alleles in 13 genetic backgrounds
    32 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one allele disrupting this imprinting control region (or differentially methylated region) between H19 and Igf2 exhibit normal methylation imprinting. An allele replacing it with the chicken beta globin chromatin insulator results in the lack of Igf2 activation and H19 suppression when paternally inherited, leading to smaller mice.
References
more
  • Summaries
    All 38
    Phenotypes 38
  • Earliest
    J:28716 Leighton PA, et al., An enhancer deletion affects both H19 and Igf2 expression. Genes Dev. 1995 Sep 1;9(17):2079-89
  • Latest
    J:311547 Park KS, et al., Cardiac pathologies in mouse loss of imprinting models are due to misexpression of H19 long noncoding RNA. Elife. 2021 Aug 17;10

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory