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Mirc32 Complex/Cluster/Region Detail
Summary
  • Symbol
    Mirc32
  • Name
    microRNA cluster 32, including Mir143 and Mir145a
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:5447365
  • Cluster Members
    Mir145a, Mir143 (2 members)
Location &
Maps
more
  • Sequence Map
    Chr18:61647825-61649258 bp
  • From MGI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, Syntenic
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 6 alleles in 7 genetic backgrounds
    4 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit vascular smooth muscle hypotrophy, decreased blood pressure, decreased heart weight, and failure to respond normally to carotide artery ligation.
Other Database
Links
less
References
more
  • Summaries
    All 14
    Phenotypes 12
  • Earliest
    J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
  • Latest
    J:266098 Lam J, et al., miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFbeta signaling. Nat Commun. 2018 Jun 20;9(1):2418

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
09/17/2019
MGI 6.14
The Jackson Laboratory