Mirc20 MGI Mouse Complex/Cluster/Region Detail - MGI:5313577 - microRNA cluster 20, including Mir302b through Mir367

Mirc20 Complex/Cluster/Region Detail

Symbol

Mirc20
Name

microRNA cluster 20, including Mir302b through Mir367

Feature Type

complex/cluster/region
IDs

MGI:5313577
Cluster Members

Mir302b, Mir302c, Mir302a ... (5 members)

Sequence Map

Chr3:127338877-127339456 bp
From MGI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, Syntenic

SNPs within 2kb

36 from dbSNP Build 142

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotypes from multigenic genotypes
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Targeted

5
Genomic Mutations

2 involving Mirc20
Find Mice (IMSR)

1 strains or lines available

Mice homozygous for a conditional allele activated in cardiac tissue exhibit normal programmed cell death and viability. Mice homozygous for a knock-out allele exhibit lethality during fetal development, incomplete rostral neuropore closure, exencephaly and precocious neuronal development.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

7
Tissues

7
Literature Summary

1

Tissue x Stage Matrix

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miRBase

MI0000402, MI0003531, MI0003716, MI0003717, MI0003718

Summaries

All 10

Developmental Gene Expression 1

Phenotypes 8
Earliest

J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
Latest

J:333726 Keuls RA, et al., Post-transcriptional regulation in cranial neural crest cells expands developmental potential. Proc Natl Acad Sci U S A. 2023 Feb 7;120(6):e2212578120

Mirc20 Cluster contains:

More Data for these features

Member	Feature Type	Location
Mir302b, microRNA 302b	miRNA gene	Chr3:127338877-127338950 (+)
Mir302c, microRNA 302c	miRNA gene	Chr3:127339012-127339079 (+)
Mir302a, microRNA 302a	miRNA gene	Chr3:127339145-127339213 (+)
Mir302d, microRNA 302d	miRNA gene	Chr3:127339273-127339338 (+)
Mir367, microRNA 367	miRNA gene	Chr3:127339382-127339456 (+)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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