Tg(Tert-cre/ERT2)1Brlt
Transgene Detail

Summary

• Symbol: Tg(Tert-cre/ERT2)1Brlt
• Name: transgene insertion 1, David T Breault
• MGI ID: MGI:4941319
• Synonyms: mTert-CreER
• Transgene: Tg(Tert-cre/ERT2)1Brlt Location: unknown
• Alliance: Tg(Tert-cre/ERT2)1Brlt page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:169012
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Tert-cre/ERT2)1Brlt expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tert (MGI:1202709)

• Mutation details: A cre/ERT2 cassette was cloned into a vector containing 4.4 kb of the murine Tert promoter. The linearized construct was electroporated into J1 ES cells for integration. 3 clones were selected for blastocyst injection and three chimeras were generated. One line containing 10 copies of the transgene was selected for further analysis. (J:169012)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tert (mouse) Summary of all recombinase alleles driven by Tert. Alliance mouse Tert gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:169012 Montgomery RK, et al., Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):179-84
• All: 1 reference(s)