Del(7Ipw-Snord116)1Jbro Cytogenetic Marker Detail

Summary

• Symbol
  Del(7Ipw-Snord116)1Jbro
• Name
  deletion, chr 7, Jurgen Brosius 1

• Feature Type
  chromosomal deletion
• IDs
  MGI:4356429

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 7, Syntenic

Human Diseases

• Diseases
  1 with Del(7Ipw-Snord116)1Jbro mouse models

Human Disease

Mouse Models

Prader-Willi syndrome

IDs

Prader-Willi syndrome      

DOID:11983
ICD10CM:Q87.11
ICD9CM:759.81
MESH:D011218
NCI:C75463
OMIM:176270
ORDO:739
UMLS_CUI:C0032897

View 1 model

Mouse Models

Human Disease Modeled: Prader-Willi syndrome

Allelic Composition	Genetic Background	Reference	Phenotypes
Del(7Ipw-Snord116)1Jbro/+	involves: 129S7/SvEvBrd * C57BL/6	J:242655	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  9 phenotypes from 1 allele in 4 genetic backgrounds
  8 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous or heterozygous for the deletion when inherited paternally exhibit postnatal growth retardation and decreased body weight.

References

• Summaries
  All 9

  Diseases 1

  Phenotypes 8
• Earliest
  J:152022 Skryabin BV, et al., Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal growth retardation. PLoS Genet. 2007 Dec 28;3(12):e235
• Latest
  J:301806 Pace M, et al., Loss of Snord116 impacts lateral hypothalamus, sleep, and food-related behaviors. JCI Insight. 2020 Jun 18;5(12)