Tg(DMPK/tetO-EGFP/DMPK)5-313Masm
Transgene Detail

Summary

• Symbol: Tg(DMPK/tetO-EGFP/DMPK)5-313Masm
• Name: transgene insertion 5-313, Mani S Mahadevan
• MGI ID: MGI:3813454
• Synonyms: DM5, GFP-DMPK 3' UTR
• Transgene: Tg(DMPK/tetO-EGFP/DMPK)5-313Masm Location: unknown
• Alliance: Tg(DMPK/tetO-EGFP/DMPK)5-313Masm page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(DMPK/tetO-EGFP/DMPK)5-313Masm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DMPK (1760)

  Dmpk	(MGI:94906)

• Mutation details: The human promoter was fused to seven copies of the tetracycline responsive element (TRE) to drive expression of the 5'UTR followed by an EGFP gene fused to the 3'UTR contained 5 CTG repeats and the first intron. The fusion product is expressed in accordance with the expression pattern of the endogenous promoter. Two lines were created (5-313 and 5-336). (J:113088)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:113088 Mahadevan MS, et al., Reversible model of RNA toxicity and cardiac conduction defects in myotonic dystrophy. Nat Genet. 2006 Sep;38(9):1066-70
• All: 8 reference(s)