Tg(TcrLCMV)Aox
Transgene Detail
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Symbol: |
Tg(TcrLCMV)Aox |
Name: |
transgene insertion, Annette Oxenius |
MGI ID: |
MGI:3789674 |
Synonyms: |
Smarta |
Transgene: |
Tg(TcrLCMV)Aox Location: unknown
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Alliance: |
Tg(TcrLCMV)Aox page
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Strain of Origin: |
Not Applicable
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(TcrLCMV)Aox expresses
2 genes
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Mutation details: Two expression cassettes, one containing a 17.5 kb Tcr Valpha2.3-JalphaDK1 rearrangement and the other containing a 19.5 kb Tcr Vbeta8.3-Jbeta2.5 rearrangement, were coinjected into fertilized eggs. The injected fragments are specific for the LCMV GP-derived epitope P13 (amino acids 61-80) in the context of H2-IAb. Two transgenic mouse lines (referred to as Smarta1 and Smarta2) were derived from a single transgenic founder. Each sub-line was given its own allele because of phenotypic differences between the sub-lines.
(J:92228)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:92228 Oxenius A, et al., Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur J Immunol. 1998 Jan;28(1):390-400 |
All: |
102 reference(s) |
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