Tg(Gata6-lacZ)1Fut
Transgene Detail

Summary

• Symbol: Tg(Gata6-lacZ)1Fut
• Name: transgene insertion 1, Masamitsu Futai
• MGI ID: MGI:3697605
• Synonyms: GATA6/lacZ-1
• Transgene: Tg(Gata6-lacZ)1Fut Location: unknown
• Alliance: Tg(Gata6-lacZ)1Fut page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: 4.9 kb of 5' flanking sequence, the untranslated first exon, the 1.3 kb first intron and 513 bp of exon 2 of the mouse gene encoding GATA binding protein 6 reside upstream of the E. coli beta-galactosidase gene (lacZ). X-gal staining demonstrates expression of the transgenic enzyme in the developing heart and overlying thoracic wall, stomach lumen, hepatic sinusoids, bladder wall, and tracheal and bronchial epithelium. No expression was observed in the large or small intestine, urogenital tract (other than the bladder) or testis of the developing embryo. In the adult mouse, expression is confined to the heart. (J:61227)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Embryonic and adult offspring of 3 founder mice (of 10 transgene-positive mice) exhibited similar/identical patterns of X-gal staining. No distinction was made among them.

References

• Original: J:61227 Sun-Wada GH, et al., Upstream regions directing heart-specific expression of the GATA6 gene during mouse early development. J Biochem. 2000 Apr;127(4):703-9
• All: 1 reference(s)