Tg(BAT-lacZ)3Picc
Transgene Detail

Summary

• Symbol: Tg(BAT-lacZ)3Picc
• Name: transgene insertion 3, Stefano Piccolo
• MGI ID: MGI:3697064
• Synonyms: Batgal, BAT-gal, BAT::gal, BATGAL, BAT^nlacZ
• Transgene: Tg(BAT-lacZ)3Picc Location: unknown Genetic Position: Chr11, Syntenic
• Alliance: Tg(BAT-lacZ)3Picc page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: Mice with this transgene express nuclear beta-galactosidase under control of the beta-catenin-activated transgene (BAT) promoter. This promoter consists of a DNA fragment extending 0.13 kb upstream from the translation start site of the novel protein containing homeodomain (siamois) gene of Xenopus laevis, which contains the (beta-catenin non-responsive) minimal promoter of this natively beta-catenin activated gene, downstream of seven synthetic lymphoid enhancer factor/T-cell factor- (LEF/TCF-) binding sites that effectively restore the promoter's beta-catenin responsiveness. The transgene does not segregate randomly with respect to the Jup locus indicating that the transgene insertion site is genetically linked to Jup. (J:82727)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

This is one of three "BAT-gal" transgenic lines generated, which the authors state exhibitied "qualitatively identical expression patterns, although quantitative differences could be observed."

References

• Original: J:82727 Maretto S, et al., Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3299-304
• All: 199 reference(s)